The structural basis of intraflagellar transport at a glance

Shulin packages axonemal outer dynein arms for ciliary targeting

(2021) Girish R. Mali et al.   SCIENCE

The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions

(2021) Wen-Ting Yang et al.   Frontiers in Cell and Developmental Biology

Structure and activation mechanism of the BBSome membrane protein trafficking complex

(2020) Sandeep K Singh et al.   eLife

Architecture of the IFT ciliary trafficking machinery and interplay between its components

(2020) Kazuhisa Nakayama et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Optimal sidestepping of intraflagellar transport kinesins regulates structure and function of sensory cilia

(2020) Chao Xie et al.   EMBO JOURNAL

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling

(2020) Paurav B. Desai et al.   JOURNAL OF CELL BIOLOGY

Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas

(2020) Julie Craft Van De Weghe et al.   JOURNAL OF CELL SCIENCE

IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport

(2020) Xin Zhu et al.   EMBO JOURNAL

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

(2019) Tyler Picariello et al.   JOURNAL OF CELL SCIENCE

Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly

(2019) Stefanie Wachter et al.   EMBO JOURNAL

The dynamic and structural properties of axonemal tubulins support the high length stability of cilia

(2019) Ron Orbach et al.   Nature Communications

A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue

(2019) Miroslava Schaffer et al.   NATURE METHODS

The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach

(2019) Hui-Ting Chou et al.   STRUCTURE

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains

(2019) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia

(2019) Shohei Nozaki et al.   Biology Open

The molecular machines that traffic signaling receptors into and out of cilia

(2018) Maxence V Nachury   CURRENT OPINION IN CELL BIOLOGY

Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis

(2018) Teruki Funabashi et al.   JOURNAL OF CELL BIOLOGY

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length

(2018) Emily L. Hunter et al.   MOLECULAR BIOLOGY OF THE CELL

The Bardet–Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export

(2018) Peiwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

(2018) Shi-Rong Hong et al.   Nature Communications

Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis

(2018) Michael Taschner et al.   eLife

Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

(2018) Anthony J. Roberts   BIOCHEMICAL SOCIETY TRANSACTIONS

In vivo analyses of radial spoke transport, assembly, repair and maintenance

(2018) Karl F. Lechtreck et al.   Cytoskeleton

In vivo analysis of outer arm dynein transport reveals cargo-specific IFT properties

(2018) Jin Dai et al.   MOLECULAR BIOLOGY OF THE CELL

Reconstitution reveals motor activation for intraflagellar transport

(2018) Mohamed A. A. Mohamed et al.   NATURE

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum

(2018) Eloïse Bertiaux et al.   JOURNAL OF CELL BIOLOGY

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

(2018) Mareike A. Jordan et al.   NATURE CELL BIOLOGY

Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip

(2018) Jona Mijalkovic et al.   Cell Reports

Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46–IFT56 as well as on its nuclear localization signal

(2017) Teruki Funabashi et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia

(2017) Jona Mijalkovic et al.   Nature Communications

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics of the IFT machinery at the ciliary tip

(2017) Alexander Chien et al.   eLife

IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

(2017) Jenna L Wingfield et al.   eLife

Cilia Train Spotting

(2016) Stefanie Kuhns et al.   DEVELOPMENTAL CELL

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex

(2016) Michael Taschner et al.   EMBO JOURNAL

Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex

(2016) Yohei Katoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin

(2016) Tomohiro Kubo et al.   JOURNAL OF CELL SCIENCE

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

(2016) Jaimee Reck et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

Assembly of IFT Trains at the Ciliary Base Depends on IFT74

(2015) Jason M. Brown et al.   CURRENT BIOLOGY

Chlamydomonasaxonemal dynein assembly locusODA8encodes a conserved flagellar protein needed for cytoplasmic maturation of outer dynein arm complexes

(2015) Paurav B. Desai et al.   Cytoskeleton

Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism

(2015) Julie M. Craft et al.   JOURNAL OF CELL BIOLOGY

Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas

(2015) Tomohiro Kubo et al.   MOLECULAR BIOLOGY OF THE CELL

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia

(2015) Bram Prevo et al.   NATURE CELL BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteins of the Ciliary Axoneme Are Found on Cytoplasmic Membrane Vesicles during Growth of Cilia

(2014) Christopher R. Wood et al.   CURRENT BIOLOGY

FLA8/KIF3B Phosphorylation Regulates Kinesin-II Interaction with IFT-B to Control IFT Entry and Turnaround

(2014) Yinwen Liang et al.   DEVELOPMENTAL CELL

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment

(2014) Thibaut Eguether et al.   DEVELOPMENTAL CELL

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

(2014) Michael Taschner et al.   JOURNAL OF CELL BIOLOGY

Subunit composition of the human cytoplasmic dynein-2 complex

(2014) D. Asante et al.   JOURNAL OF CELL SCIENCE

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

A Differential Cargo-Loading Model of Ciliary Length Regulation by IFT

(2013) Kathryne N. Wren et al.   CURRENT BIOLOGY

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

(2013) S. Bhogaraju et al.   SCIENCE

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

(2012) Karel F. Liem et al.   JOURNAL OF CELL BIOLOGY

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function

(2012) Benjamin D. Engel et al.   JOURNAL OF CELL BIOLOGY

Dissecting the Sequential Assembly and Localization of Intraflagellar Transport Particle Complex B in Chlamydomonas

(2012) Elizabeth A. Richey et al.   PLoS One

Architecture and function of IFT complex proteins in ciliogenesis

(2011) Michael Taschner et al.   DIFFERENTIATION

Crystal structure of the intraflagellar transport complex 25/27

(2011) Sagar Bhogaraju et al.   EMBO JOURNAL

How kinesin-2 forms a stalk

(2011) Marija Vukajlovic et al.   MOLECULAR BIOLOGY OF THE CELL

Probing the role of IFT particle complex A and B in flagellar entry and exit of IFT-dynein in Chlamydomonas

(2011) Shana M. Williamson et al.   PROTOPLASMA

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

(2010) Jacqueline S. Domire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

(2010) Tomohiro Kubo et al.   CURRENT BIOLOGY

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

KAP, the Accessory Subunit of Kinesin-2, Binds the Predicted Coiled-Coil Stalk of the Motor Subunits†

(2009) Harinath Doodhi et al.   BIOCHEMISTRY

Retrograde Intraflagellar Transport Mutants Identify Complex A Proteins With Multiple Genetic Interactions in Chlamydomonas reinhardtii

(2009) C. Iomini et al.   GENETICS

Electron-tomographic analysis of intraflagellar transport particle trains in situ

(2009) Gaia Pigino et al.   JOURNAL OF CELL BIOLOGY

Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model

(2009) Benjamin D. Engel et al.   JOURNAL OF CELL BIOLOGY

TheChlamydomonas reinhardtiiBBSome is an IFT cargo required for export of specific signaling proteins from flagella

(2009) Karl-Ferdinand Lechtreck et al.   JOURNAL OF CELL BIOLOGY

The reciprocal coordination and mechanics of molecular motors in living cells

(2009) J. A. Laib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

(2008) Noveera T. Ahmed et al.   JOURNAL OF CELL BIOLOGY