INPP5E regulates phosphoinositide-dependent cilia transition zone function

Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans

(2016) Hassan Badrane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

(2016) Sandra Hakim et al.   HUMAN MOLECULAR GENETICS

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

(2016) Kasturi Pal et al.   JOURNAL OF CELL BIOLOGY

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

(2016) Bomi Jung et al.   Scientific Reports

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance

(2015) V. L. Jensen et al.   EMBO JOURNAL

TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone

(2015) Elle C. Roberson et al.   JOURNAL OF CELL BIOLOGY

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

(2015) Gisela G Slaats et al.   JOURNAL OF MEDICAL GENETICS

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

(2015) Nils J. Lambacher et al.   NATURE CELL BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone

(2015) T. Tony Yang et al.   Scientific Reports

Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila

(2015) Jina Park et al.   Cell Reports

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling

(2015) Laura E. Yee et al.   PLoS Genetics

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability

(2014) O. V. Plotnikova et al.   JOURNAL OF CELL SCIENCE

Septin assemblies form by diffusion-driven annealing on membranes

(2014) Andrew A. Bridges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

(2014) Jozsef Maléth et al.   Nature Communications

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Phenotypic spectrum and prevalence of INPP5E mutations in Joubert Syndrome and related disorders

(2013) Lorena Travaglini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A HomozygousPDE6DMutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

(2013) Sophie Thomas et al.   HUMAN MUTATION

Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length

(2013) R. Ghossoub et al.   JOURNAL OF CELL SCIENCE

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

(2013) Sebiha Cevik et al.   PLoS Genetics

Rapid Redistribution of Phosphatidylinositol-(4,5)-Bisphosphate and Septins during the Candida albicans Response to Caspofungin

(2012) Hassan Badrane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Septins: the fourth component of the cytoskeleton

(2012) Serge Mostowy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

(2012) V. M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone

(2011) Lijia Huang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells

(2011) Stephen S. Francis et al.   JOURNAL OF CELL BIOLOGY

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

Eye development genes and known syndromes

(2011) Anne M. Slavotinek   MOLECULAR GENETICS AND METABOLISM

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Complex interactions between genes controlling trafficking in primary cilia

(2011) Polloneal Jymmiel R Ocbina et al.   NATURE GENETICS

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Sonic hedgehog mutations are an uncommon cause of developmental eye anomalies

(2010) Preeti Bakrania et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Binding of p110 Retinoblastoma Protein Inhibits Nuclear Import of Simian Virus SV40 Large Tumor Antigen

(2010) Alex James Fulcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

The CIL-1 PI 5-Phosphatase Localizes TRP Polycystins to Cilia and Activates Sperm in C. elegans

(2009) Young-Kyung Bae et al.   CURRENT BIOLOGY

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of PtdIns(3,4,5)P3dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods

(2008) Shu-Chin Yip et al.   BIOCHEMICAL JOURNAL

Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis

(2008) H.-C. Wei et al.   JOURNAL OF CELL SCIENCE

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development

(2008) P. G. Matteson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA