Targeting α-synuclein post-translational modifications in Parkinson’s disease
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting α-synuclein post-translational modifications in Parkinson’s disease
Authors
Keywords
-
Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 439, Issue -, Pages 114204
Publisher
Elsevier BV
Online
2022-11-12
DOI
10.1016/j.bbr.2022.114204
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
- (2022) Haley M Geertsma et al. HUMAN MOLECULAR GENETICS
- Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
- (2022) Shiori Awa et al. Scientific Reports
- The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
- (2022) Azad Farzadfard et al. Communications Biology
- O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies
- (2022) Bruno Permanne et al. ACS Chemical Neuroscience
- Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition
- (2022) Azad Farzadfard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity
- (2022) Simona S. Ghanem et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
- (2022) Keunjung Heo et al. Frontiers in Cellular Neuroscience
- Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
- (2022) Takashi Ohgita et al. Scientific Reports
- Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy
- (2022) Berkiye Sonustun et al. Cells
- Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease
- (2022) Chao-Wen Lin et al. GeroScience
- Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
- (2022) Ana Chegão et al. npj Parkinsons Disease
- Rapid macropinocytic transfer of α-synuclein to lysosomes
- (2022) Armin Bayati et al. Cell Reports
- Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
- (2022) Ying Xue Xie et al. Nature Communications
- Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders
- (2021) Vasilios C. Constantinides et al. Brain Sciences
- Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
- (2021) Cristina Román-Vendrell et al. Frontiers in Neuroscience
- Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease
- (2021) Songzhe He et al. ACS Chemical Neuroscience
- Cerebrospinal α‐Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
- (2021) Nour K. Majbour et al. MOVEMENT DISORDERS
- In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129
- (2021) Leah J. Weston et al. NEUROBIOLOGY OF DISEASE
- DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
- (2021) Marcelo Santos da Silva Frontiers in Cell and Developmental Biology
- Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit
- (2021) Alessandro Tozzi et al. BRAIN
- Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice
- (2021) Rossana Di Martino et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Systematic Assessment of 10 Biomarker Candidates Focusing on α‐Synuclein‐Related Disorders
- (2021) Isabel Schulz et al. MOVEMENT DISORDERS
- The N terminus of α-synuclein dictates fibril formation
- (2021) Ryan P. McGlinchey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone post-translational modifications as potential therapeutic targets for pain management
- (2021) Jose V. Torres-Perez et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
- (2021) Qilin Tang et al. Cell Death & Disease
- Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
- (2021) Luis Fonseca-Ornelas et al. Cell Reports
- α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
- (2021) Aysegul Dilsizoglu Senol et al. PLOS BIOLOGY
- Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
- (2021) Ana Martinez Hernandez et al. Frontiers in Neuroscience
- RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies
- (2021) Ilaria Poggiolini et al. Biomolecules
- Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α‐Synuclein
- (2021) Xiangyu Teng et al. CHEMPHYSCHEM
- Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties
- (2021) Sydney E. Dent et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
- (2021) Yunpeng Sun et al. Nature Communications
- Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2
- (2021) Kazunori Sano et al. Acta Neuropathologica Communications
- Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease
- (2021) Elena Vacchi et al. npj Parkinsons Disease
- α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease
- (2021) Kathrine Stokholm et al. Biomedicines
- Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway
- (2021) Li Sun et al. Cell Death Discovery
- Molecular mechanisms in SUMO conjugation
- (2020) Nathalia Varejão et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Alpha-synuclein fragments trigger distinct aggregation pathways
- (2020) Tasnim Chakroun et al. Cell Death & Disease
- The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
- (2020) Matteo Runfola et al. Scientific Reports
- Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease
- (2020) Chun-Wei Chang et al. Frontiers in Neurology
- Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein pre‐formed‐fibrils
- (2020) Omid Tavassoly et al. FEBS Journal
- N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity
- (2020) Rodrigo Vinueza-Gavilanes et al. NEUROBIOLOGY OF DISEASE
- Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy
- (2020) Zachary A. Sorrentino et al. NEUROSCIENCE LETTERS
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
- (2020) Kun Zhao et al. Nature Communications
- CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers
- (2020) Nour K. Majbour et al. Translational Neurodegeneration
- Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review
- (2020) Larissa-Nele Schaffert et al. Brain Sciences
- Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
- (2020) Yuan Guan et al. Frontiers in Cellular Neuroscience
- Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
- (2020) Amberley D. Stephens et al. Nature Communications
- SUMOylation in α-Synuclein Homeostasis and Pathology
- (2020) Mor Savyon et al. Frontiers in Aging Neuroscience
- Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson’s Disease: The Implications of Sample Thickness on Results
- (2020) Ningshan Wang et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect
- (2020) Kai Wu et al. PHYSICAL BIOLOGY
- Deciphering protein post-translational modifications using chemical biology tools
- (2020) Anne C. Conibear Nature Reviews Chemistry
- The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models
- (2020) Dinesh Kumar Verma et al. eNeuro
- Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein
- (2020) Lilit Gabrielyan et al. JOURNAL OF ALZHEIMERS DISEASE
- Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study
- (2020) Lu-Lu Bu et al. Frontiers in Aging Neuroscience
- New Insights Into Drug Discovery Targeting Tau Protein
- (2020) Yoshiyuki Soeda et al. Frontiers in Molecular Neuroscience
- Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20
- (2020) Briana R. De Miranda et al. npj Parkinsons Disease
- Modification by glyceraldehyde-3-phosphate prevents amyloid transformation of alpha-synuclein
- (2019) Kseniya Barinova et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease
- (2019) Paul M. Levine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations
- (2019) Brenden J. D. Hawk et al. Frontiers in Neuroscience
- Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution
- (2019) Xi Li et al. Scientific Reports
- Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern
- (2019) Daniel Jacobs et al. Scientific Reports
- Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration
- (2019) Valentina Durante et al. BRAIN
- Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase
- (2019) Pavel Semenyuk et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Post-translational regulation of ubiquitin signaling
- (2019) Lei Song et al. JOURNAL OF CELL BIOLOGY
- Effects of alpha‐synuclein posttranslational modifications on metal binding
- (2019) Nazareno González et al. JOURNAL OF NEUROCHEMISTRY
- Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade
- (2019) Connie Marras et al. MOVEMENT DISORDERS
- The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
- (2019) Jiaming Zhang et al. Frontiers in Neuroscience
- Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease
- (2019) Chen Tian et al. Translational Neurodegeneration
- Longitudinal analyses of cerebrospinal fluid α‐Synuclein in prodromal and early Parkinson's disease
- (2019) Brit Mollenhauer et al. MOVEMENT DISORDERS
- A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology
- (2019) Juan A. Gerez et al. Science Translational Medicine
- Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
- (2019) Allison J. Schaser et al. Scientific Reports
- Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein
- (2019) Katsuya Araki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
- (2019) Cristina Cariulo et al. Frontiers in Neuroscience
- Parkinson disease
- (2019) R. Balestrino et al. EUROPEAN JOURNAL OF NEUROLOGY
- CSF or serum neurofilament light added to α‐Synuclein panel discriminates Parkinson's from controls
- (2019) Linda P. Oosterveld et al. MOVEMENT DISORDERS
- Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons
- (2019) Goutham K. Ganjam et al. Cell Death & Disease
- Role of Post‐translational Modifications in Alzheimer's Disease
- (2019) Madhu Ramesh et al. CHEMBIOCHEM
- The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation, succinylation, and prenylation
- (2019) Jinning Gao et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion
- (2019) Stuart P. Moon et al. JOURNAL OF ORGANIC CHEMISTRY
- Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates
- (2019) Shamini Vijayakumaran et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The many substrates and functions of NEDD4-1
- (2019) Xi Huang et al. Cell Death & Disease
- Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation
- (2018) Cristine Betzer et al. EMBO REPORTS
- Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces
- (2018) Matteo Rovere et al. FEBS LETTERS
- Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease
- (2018) Fudong Yan et al. MEDICINE
- Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity
- (2018) Isabel Ortuño-Lizarán et al. MOVEMENT DISORDERS
- Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death
- (2018) Lasse Reimer et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
- (2018) Iryna Prots et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
- (2018) Marthe H. R. Ludtmann et al. Nature Communications
- The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality
- (2018) Jyotiska Chaudhuri et al. Cell Metabolism
- Alpha-Synuclein Modulates the Physical Properties of DNA
- (2018) Kai Jiang et al. CHEMISTRY-A EUROPEAN JOURNAL
- Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein
- (2018) Raquel Pinho et al. HUMAN MOLECULAR GENETICS
- Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt–Jakob Disease and Synucleinopathy
- (2018) Matthias Schmitz et al. MOLECULAR NEUROBIOLOGY
- Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease
- (2018) Najiba Mammadova et al. NEUROBIOLOGY OF DISEASE
- Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum
- (2018) Thaiany Quevedo Melo et al. NEUROCHEMICAL RESEARCH
- Endoplasmic reticulum stress and apoptosis induced by manganese trigger α-synuclein accumulation
- (2018) Hyonok Yoon et al. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
- The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
- (2017) Fatima Ardito et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease
- (2017) Velmarini Vasquez et al. JOURNAL OF ALZHEIMERS DISEASE
- Epidemiology of Parkinson’s disease
- (2017) Ole-Bjørn Tysnes et al. JOURNAL OF NEURAL TRANSMISSION
- Protein O-GlcNAcylation: emerging mechanisms and functions
- (2017) Xiaoyong Yang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Non-motor features of Parkinson disease
- (2017) Anthony H.V. Schapira et al. NATURE REVIEWS NEUROSCIENCE
- SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation
- (2017) Ruth Rott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease
- (2017) Jenny-Ann Phan et al. Scientific Reports
- Cell Biology and Pathophysiology of α-Synuclein
- (2017) Jacqueline Burré et al. Cold Spring Harbor Perspectives in Medicine
- O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease
- (2017) Willayat Y. Wani et al. Molecular Brain
- Levodopa in Parkinson’s Disease: Current Status and Future Developments
- (2017) Nicola Tambasco et al. Current Neuropharmacology
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
- (2017) Hugo Vicente Miranda et al. Scientific Reports
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- Alzheimer’s and Parkinson’s Diseases: Expected Economic Impact on Europe—A Call for a Uniform European Strategy
- (2016) Petra Maresova et al. JOURNAL OF ALZHEIMERS DISEASE
- SUMO-regulated mitochondrial function in Parkinson's disease
- (2016) Ana Cristina Guerra de Souza et al. JOURNAL OF NEUROCHEMISTRY
- Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
- (2016) Nour K. Majbour et al. Molecular Neurodegeneration
- Motor symptoms in Parkinson’s disease: A unified framework
- (2016) Ahmed A. Moustafa et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
- (2016) Wenyan Kang et al. Scientific Reports
- Phosphorylation induces distinct alpha-synuclein strain formation
- (2016) Meng-Rong Ma et al. Scientific Reports
- Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo
- (2015) Martial Kamdem Mbefo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
- (2015) Filsy Samuel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- Ubiquitination of α-synuclein and autophagy in Parkinson's disease
- (2014) Simone Engelender Autophagy
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein
- (2014) Riccardo Porcari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity
- (2014) César L. Ávila et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
- (2014) Eric S. Luth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Function and Regulation of the Na+-Ca2+Exchanger NCX3 Splice Variants in Brain and Skeletal Muscle
- (2014) Lauriane Y. M. Michel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence of Native α-Synuclein Conformers in the Human Brain
- (2014) Neal Gould et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
- (2014) Ossama Khalaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein
- (2014) Nicola J. Rutherford et al. JOURNAL OF NEUROCHEMISTRY
- Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
- (2014) Rita Perfeito et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
- (2014) Giuliana Fusco et al. Nature Communications
- Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
- (2014) Mathieu Bourdenx et al. Frontiers in Neuroanatomy
- A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism
- (2014) Eleanna Kara et al. JAMA Neurology
- In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain
- (2013) M. Bergeron et al. NEUROSCIENCE
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context
- (2012) Vicente Sancenon et al. HUMAN MOLECULAR GENETICS
- Mutant Protein A30P α-Synuclein Adopts Wild-type Fibril Structure, Despite Slower Fibrillation Kinetics
- (2012) Luisel R. Lemkau et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endoplasmic Reticulum Stress Is Important for the Manifestations of -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- Protein Electrostatic Properties Predefining the Level of Surface Hydrophobicity Change upon Phosphorylation
- (2012) Anton A. Polyansky et al. Journal of Physical Chemistry Letters
- Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials
- (2012) Lorraine V. Kalia et al. MOVEMENT DISORDERS
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies
- (2012) Diana L. Castillo-Carranza et al. NEUROCHEMICAL RESEARCH
- Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation
- (2011) Yohan Oh et al. BRAIN RESEARCH
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast
- (2011) Katherina Vamvaca et al. JOURNAL OF NEUROCHEMISTRY
- Enhanced Phosphatase Activity Attenuates -Synucleinopathy in a Mouse Model
- (2011) K.-W. Lee et al. JOURNAL OF NEUROSCIENCE
- ER stress response plays an important role in aggregation of α-synuclein
- (2011) Peizhou Jiang et al. Molecular Neurodegeneration
- Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
- (2011) P.G. Foulds et al. NEUROBIOLOGY OF DISEASE
- SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
- (2011) Blake Byers et al. PLoS One
- Ubiquitin ligase Nedd4 promotes -synuclein degradation by the endosomal-lysosomal pathway
- (2011) G. K. Tofaris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
- (2010) Jobin Varkey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
- (2010) Christopher G. Evans et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
- (2009) Hong Qing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate
- (2009) Isao Fukuda et al. CHEMISTRY & BIOLOGY
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- Neuropsychiatric symptoms in Parkinson's disease
- (2009) Dag Aarsland et al. MOVEMENT DISORDERS
- Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice
- (2009) H. Schell et al. NEUROSCIENCE
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Non-motor symptoms in Parkinson’s disease
- (2008) W. Poewe EUROPEAN JOURNAL OF NEUROLOGY
- Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
- (2008) Kelly J. Inglis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search