α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

(2021) Wing K. Man et al.   Nature Communications

Tunneling nanotubes: Reshaping connectivity

(2021) Chiara Zurzolo   CURRENT OPINION IN CELL BIOLOGY

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

(2020) Amulya Nidhi Shrivastava et al.   BIOPHYSICAL JOURNAL

The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes

(2020) Lin Cui et al.   Frontiers in Cell and Developmental Biology

The Lysosome at the Intersection of Cellular Growth and Destruction

(2020) Hijai R. Shin et al.   DEVELOPMENTAL CELL

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

(2020) Shuhei Nakamura et al.   NATURE CELL BIOLOGY

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

(2019) Mingzhu Huang et al.   Frontiers in Neuroscience

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

(2019) Anna-Carin Hoffmann et al.   Scientific Reports

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

(2019) Jessica Y. Vargas et al.   AGEING RESEARCH REVIEWS

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

(2019) Jichao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Effect of tolytoxin on tunneling nanotube formation and function

(2019) Aysegul Dilsizoglu Senol et al.   Scientific Reports

Human NPCs can degrade α–syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures

(2019) Clara Grudina et al.   NEUROBIOLOGY OF DISEASE

Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity

(2019) Xue Yang et al.   Scientific Reports

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

(2018) Nolwen L. Rey et al.   NEUROBIOLOGY OF DISEASE

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy

(2018) Job Fermie et al.   TRAFFIC

Mechanisms of lysosomal positioning and movement

(2018) Birol Cabukusta et al.   TRAFFIC

Lysosome biogenesis in health and disease

(2018) Lakshya Bajaj et al.   JOURNAL OF NEUROCHEMISTRY

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

(2017) Jinzhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases

(2017) Guiliana Soraya Victoria et al.   JOURNAL OF CELL BIOLOGY

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

(2017) Rose Willett et al.   Nature Communications

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

(2017) Peizhou Jiang et al.   Scientific Reports

Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

(2017) Seng Zhu et al.   Open Biology

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

(2017) Birger Victor Dieriks et al.   Scientific Reports

What lysosomes actually tell us about Parkinson’s disease?

(2016) Mathieu Bourdenx et al.   AGEING RESEARCH REVIEWS

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

(2016) Jacob I. Ayers et al.   JOURNAL OF VIROLOGY

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks

(2016) Carlos M. Guardia et al.   Cell Reports

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

(2016) Guiliana Soraya Victoria et al.   Scientific Reports

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations

(2015) Marvin Bentley et al.   JOURNAL OF CELL BIOLOGY

Brain region-dependent differential expression of alpha-synuclein

(2015) Katsutoshi Taguchi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Brief Reports: Lysosomal Cross-Correction by Hematopoietic Stem Cell-Derived Macrophages Via Tunneling Nanotubes

(2014) Swati Naphade et al.   STEM CELLS

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Lysosomal Adaptation: How the Lysosome Responds to External Cues

(2014) C. Settembre et al.   Cold Spring Harbor Perspectives in Biology

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein pore forming activity upon membrane association

(2012) Laura Tosatto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction

(2012) Yashar Seyed-Razavi et al.   IMMUNOLOGY AND CELL BIOLOGY

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

The delivery of endocytosed cargo to lysosomes: Figure 1

(2009) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Patch-Based Nonlocal Functional for Denoising Fluorescence Microscopy Image Sequences

(2009) J. Boulanger et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging and imagination: understanding the endo-lysosomal system

(2008) Eline Meel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE