Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α‐Synuclein

Rasch analysis of the living with chronic illness scale in Parkinson’s disease

(2020) Leire Ambrosio et al.   BMC Neurology

Effects of alpha‐synuclein posttranslational modifications on metal binding

(2019) Nazareno González et al.   JOURNAL OF NEUROCHEMISTRY

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases

(2019) Jiaming Zhang et al.   Frontiers in Neuroscience

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Copper2+ Binding to α-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate

(2019) Yao Tian et al.   INORGANIC CHEMISTRY

Iron promotes α-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion

(2018) Yousheng Xiao et al.   JOURNAL OF NEUROCHEMISTRY

The redox kinetics of the amyloid-β-Cu complex and its biological implications

(2018) Paul Girvan et al.   BIOCHEMISTRY

Copper signaling in the brain and beyond

(2017) Cheri M. Ackerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation

(2016) Rebecca J. Mason et al.   BIOCHEMISTRY

Kinetics of the Interactions between Copper and Amyloid-β with FAD Mutations and Phosphorylation at the N terminus

(2016) Paul Girvan et al.   CHEMBIOCHEM

Coordination and redox properties of copper interaction with α-synuclein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

(2016) Anna Villar-Piqué et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of α-Synuclein

(2015) Riccardo De Ricco et al.   INORGANIC CHEMISTRY

Copper Binding to the N-Terminally Acetylated, Naturally Occurring Form of Alpha-Synuclein Induces Local Helical Folding

(2015) Marco C. Miotto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Introduction of a Fluorescent Probe to Amyloid-β to Reveal Kinetic Insights into Its Interactions with Copper(II)

(2014) Thomas Branch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation

(2014) Gina M. Moriarty et al.   BIOCHEMISTRY

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

(2014) Riccardo Porcari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro

(2013) Dhiman Ghosh et al.   BIOCHEMISTRY

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

(2012) Andrés Binolfi et al.   COORDINATION CHEMISTRY REVIEWS

Peculiarities of Copper Binding to α-Synuclein

(2012) Atta Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

(2011) Jeppe T. Pedersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coordination Features and Affinity of the Cu2+Site in the α-Synuclein Protein of Parkinson’s Disease

(2011) Christopher G. Dudzik et al.   BIOCHEMISTRY

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

The Synucleins Are a Family of Redox-Active Copper Binding Proteins

(2010) Paul Davies et al.   BIOCHEMISTRY

Raised calcium promotes α-synuclein aggregate formation

(2010) S. Nath et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

(2008) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY