RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

Alpha-synuclein fragments trigger distinct aggregation pathways

(2020) Tasnim Chakroun et al.   Cell Death & Disease

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

(2020) Niccolo Candelise et al.   Translational Neurodegeneration

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

(2020) Marcello Rossi et al.   ACTA NEUROPATHOLOGICA

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

(2020) Anke Van der Perren et al.   ACTA NEUROPATHOLOGICA

Seeding Variability of Different Alpha Synuclein Strains in Synucleinopathies

(2019) Niccolò Candelise et al.   ANNALS OF NEUROLOGY

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

(2019) Chiara Maria Giulia De Luca et al.   Translational Neurodegeneration

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

(2019) Zachary A. Sorrentino et al.   Acta Neuropathologica Communications

α‐Synuclein real‐time quaking‐induced conversion in the submandibular glands of Parkinson's disease patients

(2019) Sireesha Manne et al.   MOVEMENT DISORDERS

Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease

(2018) David J. Koss et al.   BRAIN RESEARCH

Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

(2018) Zachary A. Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease

(2018) N. N. Vaikath et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

(2016) Graham Fairfoul et al.   Annals of Clinical and Translational Neurology

Aggregates feel the strain

(2015) Seung-Jae Lee et al.   NATURE

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson’s disease

(2014) Andrew O. Koob et al.   BRAIN RESEARCH

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

(2014) John F. Kellie et al.   Scientific Reports

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Striatal β-amyloid in dementia with Lewy bodies but not Parkinson’s disease

(2011) Glenda M. Halliday et al.   JOURNAL OF NEURAL TRANSMISSION

Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology

(2010) Karen A. Lewis et al.   AMERICAN JOURNAL OF PATHOLOGY

The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

(2003) Bruce C. V. Campbell et al.   JOURNAL OF NEUROCHEMISTRY