Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
Authors
Keywords
-
Journal
Frontiers in Cellular Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-12
DOI
10.3389/fncel.2020.00159
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Initiation and propagation of α-synuclein aggregation in the nervous system
- (2020) Baraa A. Hijaz et al. Molecular Neurodegeneration
- Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?
- (2019) David P. Breen et al. MOVEMENT DISORDERS
- Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
- (2019) Jessica M. Froula et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- How is alpha‐synuclein cleared from the cell?
- (2019) Leonidas Stefanis et al. JOURNAL OF NEUROCHEMISTRY
- Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway
- (2019) Yang Feng et al. Oxidative Medicine and Cellular Longevity
- Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis
- (2019) Michael X. Henderson et al. NATURE NEUROSCIENCE
- Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells
- (2019) Jianqun Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structurally distinct α‐synuclein fibrils induce robust parkinsonian pathology
- (2019) Hideki Hayakawa et al. MOVEMENT DISORDERS
- Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic
- (2018) S. Pablo Sardi et al. MOVEMENT DISORDERS
- Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease
- (2018) Cornelis Blauwendraat et al. NEUROBIOLOGY OF AGING
- Internalization, axonal transport and release of fibrillar forms of alpha-synuclein
- (2018) Gregor Bieri et al. NEUROBIOLOGY OF DISEASE
- Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents
- (2018) Nicole K. Polinski et al. Journal of Parkinsons Disease
- 14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein
- (2018) Bing Wang et al. JOURNAL OF NEUROSCIENCE
- Membrane binding, internalization, and sorting of alpha-synuclein in the cell
- (2018) Caterina Masaracchia et al. Acta Neuropathologica Communications
- Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine
- (2018) Mauricio dos-Santos-Pereira et al. GLIA
- Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia
- (2017) Cuilian Du et al. GLIA
- Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice
- (2017) Nicola J Rutherford et al. HUMAN MOLECULAR GENETICS
- Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
- (2017) Helena Borland et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
- (2017) Richard J. Karpowicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Α-synuclein induces microglial cell migration through stimulating HIF-1α accumulation
- (2017) Hongfei Qiao et al. JOURNAL OF NEUROSCIENCE RESEARCH
- α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
- (2017) Hisham Abdelmotilib et al. NEUROBIOLOGY OF DISEASE
- Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein
- (2017) Vedad Delic et al. NEUROMOLECULAR MEDICINE
- Baicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex
- (2017) Xingjian Li et al. NEUROSCIENCE LETTERS
- E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation
- (2017) Ignacio Íñigo-Marco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
- (2017) Ashley S. Harms et al. Acta Neuropathologica Communications
- A study on the modulation of alpha-synuclein fibrillation by Scutellaria pinnatifida extracts and its neuroprotective properties
- (2017) Mahdyeh Sashourpour et al. PLoS One
- α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication
- (2017) Suzana Aulić et al. Scientific Reports
- Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors
- (2016) Gabriel Gustafsson et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation
- (2016) Airi Tarutani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
- (2016) Dan Ploug Christensen et al. Journal of Neuroinflammation
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
- (2016) Diana F. Lázaro et al. Acta Neuropathologica Communications
- Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
- (2015) Toshiki Uchihara et al. ACTA NEUROPATHOLOGICA
- Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
- (2015) A-L Mahul-Mellier et al. CELL DEATH AND DIFFERENTIATION
- Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo
- (2015) Martial Kamdem Mbefo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies
- (2015) Anna Villar-Piqué et al. JOURNAL OF NEUROCHEMISTRY
- Alpha-synuclein propagation: New insights from animal models
- (2015) Benjamin Dehay et al. MOVEMENT DISORDERS
- Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains
- (2015) Guangwei Liu et al. NEUROBIOLOGY OF AGING
- The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture
- (2015) Nicola J. Rutherford et al. NEUROSCIENCE LETTERS
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration
- (2015) Maddalena Costanzo et al. BIOCHEMICAL JOURNAL
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Residue Histidine 50 Plays a Key Role in Protecting α-Synuclein from Aggregation at Physiological pH
- (2014) Ying-Chih Chi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
- (2014) Ossama Khalaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein
- (2014) Nicola J. Rutherford et al. JOURNAL OF NEUROCHEMISTRY
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- Alpha-synuclein spreading in Parkinson’s disease
- (2014) Ariadna Recasens et al. Frontiers in Neuroanatomy
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- α-Synuclein: The Long Distance Runner
- (2013) Sonia George et al. BRAIN PATHOLOGY
- alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology
- (2013) Sibylle E. Eisbach et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease
- (2013) Dorota Hoffman-Zacharska et al. PARKINSONISM & RELATED DISORDERS
- Update on novel familial forms of Parkinson's disease and multiple system atrophy
- (2013) Shinsuke Fujioka et al. PARKINSONISM & RELATED DISORDERS
- What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
- (2013) Christopher J.R. Dunning et al. Prion
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
- (2012) Gerard M J Beaudoin et al. Nature Protocols
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
- (2012) Elodie Angot et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Alpha-synuclein: from secretion to dysfunction and death
- (2012) O Marques et al. Cell Death & Disease
- Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
- (2011) Grit Taschenberger et al. ACTA NEUROPATHOLOGICA
- A deadly spread: cellular mechanisms of α-synuclein transfer
- (2011) J A Steiner et al. CELL DEATH AND DIFFERENTIATION
- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
- (2011) He-Jin Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
- (2011) Qi Xuan et al. JOURNAL OF NEURAL TRANSMISSION
- Pathological roles of α-synuclein in neurological disorders
- (2011) Kostas Vekrellis et al. LANCET NEUROLOGY
- Parkinson's disease and α-synuclein expression
- (2011) Michael J. Devine et al. MOVEMENT DISORDERS
- Familial Parkinson disease mutations influence α-synuclein assembly
- (2011) Kenjiro Ono et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Molecular mechanism of Thioflavin-T binding to amyloid fibrils
- (2010) Matthew Biancalana et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner
- (2010) Youhei Machiya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions
- (2010) Ara Jang et al. JOURNAL OF NEUROCHEMISTRY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- E46K Parkinson’s-Linked Mutation Enhances C-Terminal-to-N-Terminal Contacts in α-Synuclein
- (2009) Carla C. Rospigliosi et al. JOURNAL OF MOLECULAR BIOLOGY
- Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population
- (2009) Alex Rajput et al. MOVEMENT DISORDERS
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomewide association study for susceptibility genes contributing to familial Parkinson disease
- (2008) Nathan Pankratz et al. HUMAN GENETICS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research
- (2008) Yuen-Ting Cheung et al. NEUROTOXICOLOGY
- Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases
- (2008) Igor F. Tsigelny et al. PLoS One
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation