In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

(2021) Leah J. Weston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studying the Pathophysiology of Parkinson’s Disease Using Zebrafish

(2020) Lisa M. Barnhill et al.   Biomedicines

Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain

(2019) Nicole L. Brockway et al.   DEVELOPMENTAL BIOLOGY

The physiological role of α‐synuclein and its relationship to Parkinson’s Disease

(2019) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?

(2018) Suzanne Chartier et al.   CELL AND TISSUE RESEARCH

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

(2018) Farah El Turk et al.   PROTEIN SCIENCE

Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

(2018) Yixi He et al.   ACS Chemical Neuroscience

SNCA mutation p.Ala53Glu is derived from a common founder in the Finnish population

(2017) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos

(2016) Aaron Lulla et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation

(2016) Shubhangi Prabhudesai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fish Synucleins: An Update

(2015) Mattia Toni et al.   Marine Drugs

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

(2015) Kateri J. Spinelli et al.   PLoS One

Axon degeneration and PGC-1 -mediated protection in a zebrafish model of  -synuclein toxicity

(2014) K. C. O'Donnell et al.   Disease Models & Mechanisms

Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease

(2014) K. J. Spinelli et al.   JOURNAL OF NEUROSCIENCE

Transgenic mice expressing S129 phosphorylation mutations in α-synuclein

(2014) Valerie Drews Escobar et al.   NEUROSCIENCE LETTERS

Differential Expression of Alpha-Synuclein in Hippocampal Neurons

(2014) Katsutoshi Taguchi et al.   PLoS One

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

(2013) Fabia Febbraro et al.   NEUROBIOLOGY OF DISEASE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

(2013) M. Bergeron et al.   NEUROSCIENCE

Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

(2013) A. Oueslati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards understanding the phosphorylation code of tau

(2012) Guy Lippens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Hypokinesia and Reduced Dopamine Levels in Zebrafish Lacking β- and γ1-Synucleins

(2011) Chiara Milanese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos

(2010) KilHun Jeong et al.   DEVELOPMENTAL BIOLOGY

Distinct Region-Specific  -Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration

(2010) E. Tsika et al.   JOURNAL OF NEUROSCIENCE

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility

(2010) Vivek K. Unni et al.   PLoS One

Anatomy of zebrafish cerebellum and screen for mutations affecting its development

(2009) Young-Ki Bae et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease

(2009) Nikolaus R. McFarland et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structure of theBrachydanio rerioPolo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

(2008) Robert A. Elling et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Characterization of antibodies that selectively detect α-synuclein in pathological inclusions

(2008) Elisa A. Waxman et al.   ACTA NEUROPATHOLOGICA

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Discovery and characterization of three novel synuclein genes in zebrafish

(2008) Zhihui Sun et al.   DEVELOPMENTAL DYNAMICS

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The phosphorylation state of Ser-129 in human  -synuclein determines neurodegeneration in a rat model of Parkinson disease

(2008) O. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA