Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

(2021) Leah J. Weston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization

(2021) Blagovesta Popova et al.   PLoS Genetics

Partial magic angle spinning NMR 1H, 13C, 15N resonance assignments of the flexible regions of a monomeric alpha-synuclein: conformation of C-terminus in the lipid-bound and amyloid fibril states

(2021) Justin Medeiros et al.   Biomolecular NMR Assignments

In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129

(2021) Leah J. Weston et al.   NEUROBIOLOGY OF DISEASE

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

(2021) Kai Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

(2021) Sara Elfarrash et al.   PLoS One

Alteration of the Conformational Dynamics of a DNA Hairpin by α‐Synuclein in the Presence of Aqueous Two‐Phase Systems

(2020) Roland Hermann Alfons Winter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together

(2020) Qing Ye et al.   Frontiers in Aging Neuroscience

α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate

(2020) Meir Schechter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Alpha-Synuclein Modulates the Physical Properties of DNA

(2018) Kai Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

(2018) Raquel Pinho et al.   HUMAN MOLECULAR GENETICS

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

(2017) Velmarini Vasquez et al.   JOURNAL OF ALZHEIMERS DISEASE

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons

(2017) Chee Yeun Chung et al.   Cell Systems

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

(2017) Vikram Khurana et al.   Cell Systems

Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity

(2016) Thomas Thibault et al.   NUCLEIC ACIDS RESEARCH

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

(2015) Andreas S. Biebricher et al.   Nature Communications

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Analysis of Alpha-Synuclein in Malignant Melanoma – Development of a SRM Quantification Assay

(2014) Charlotte Welinder et al.   PLoS One

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

(2013) Sasuk Kim et al.   EXPERIMENTAL NEUROLOGY

Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy

(2013) Susana Gonçalves et al.   MOLECULAR NEUROBIOLOGY

Malignant melanoma in early-treated Parkinson's disease: The NET-PD trial

(2013) Radu Constantinescu et al.   MOVEMENT DISORDERS

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

(2013) Kai-Li Ma et al.   NEUROPHARMACOLOGY

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Shared Predispositions of Parkinsonism and Cancer

(2012) Seth A. Kareus et al.   ARCHIVES OF NEUROLOGY

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Malignant melanoma, breast cancer and other cancers in patients with Parkinson's disease

(2012) Kathrine Rugbjerg et al.   INTERNATIONAL JOURNAL OF CANCER

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1

(2012) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Ser129 phosphorylation of  -synuclein in melanoma cells

(2012) B. R. Lee et al.   JOURNAL OF CELL SCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Parkinson’s disease and cancer risk: a systematic review and meta-analysis

(2010) Archna Bajaj et al.   CANCER CAUSES & CONTROL

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Parkinson's Disease-Related Protein, α-Synuclein, in Malignant Melanoma

(2010) Yasuhiro Matsuo et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice

(2009) H. Schell et al.   NEUROSCIENCE

Evaluation of α-synuclein immunohistochemical methods used by invited experts

(2008) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of the matrix on DNA electrophoretic mobility

(2008) Nancy C. Stellwagen et al.   JOURNAL OF CHROMATOGRAPHY A