Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

(2022) Rajib Hossain et al.   Oxidative Medicine and Cellular Longevity

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

(2022) Mohammed M. Alshehri et al.   Oxidative Medicine and Cellular Longevity

Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

(2022) Cristina Quispe et al.   Biomed Research International

Resveratrol’ biotechnological applications: enlightening its antimicrobial and antioxidant properties

(2022) Javad Sharifi-Rad et al.   Journal of Herbal Medicine

Evaluation of BCG Vaccination and Plasma Amyloid: A Prospective, Pilot Study with Implications for Alzheimer’s Disease

(2022) Coad Thomas Dow et al.   Microorganisms

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

(2022) Praveen Dhyani et al.   Cancer Cell International

Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum

(2022) Javad Sharifi-Rad et al.   Evidence-based Complementary and Alternative Medicine

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

(2022) Yasaman Taheri et al.   Evidence-based Complementary and Alternative Medicine

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

(2022) Prabhakar Semwal et al.   Oxidative Medicine and Cellular Longevity

Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs

(2022) Rajib Hossain et al.   Biomed Research International

Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome

(2022) Michael S. Rafii et al.   JAMA Neurology

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

(2022) Ilaria Piccialli et al.   Frontiers in Pharmacology

Myricetin: targeting signaling networks in cancer and its implication in chemotherapy

(2022) Zeeshan Javed et al.   Cancer Cell International

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

(2022) Eunus S. Ali et al.   Cancer Cell International

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

(2022) Dusanka Kitic et al.   Plants-Basel

Recent advances in the therapeutic potential of emodin for human health

(2022) Javad Sharifi-Rad et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

(2022) Ruhul Amin et al.   NEUROCHEMISTRY INTERNATIONAL

Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles

(2022) Javad Sharifi-Rad et al.   Oxidative Medicine and Cellular Longevity

Santalum Genus: phytochemical constituents, biological activities and health promoting-effects

(2022) Javad Sharifi-Rad et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Dietary supplements, vitamins and minerals as potential interventions against viruses: Perspectives for COVID-19

(2021) Muhammad Torequl Islam et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

(2021) Bahare Salehi et al.   Frontiers in Pharmacology

ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease

(2021) Vasileios Siokas et al.   Journal of Clinical Medicine

Coffee Silverskin and Spent Coffee Suitable as Neuroprotectors against Cell Death by Beauvericin and α-Zearalenol: Evaluating Strategies of Treatment

(2021) Ana Juan-García et al.   Toxins

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

(2021) Dimitris Tsoukalas et al.   Journal of Clinical Medicine

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

(2021) Ashwani Arya et al.   Biomolecules

Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases

(2021) Andrea Bacci et al.   Antioxidants

Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective

(2021) Amy F. T. Arnsten et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Back to basics in COVID‐19: Antigens and antibodies—Completing the puzzle

(2021) Monica Neagu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer’s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial

(2021) Seong-Ho Koh et al.   Alzheimers Research & Therapy

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

(2021) Javad Sharifi-Rad et al.   Frontiers in Pharmacology

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

(2021) Javad Sharifi-Rad et al.   Cancer Cell International

Characterization of β-secretase inhibitory extracts from sea cucumber (Stichopus japonicus) hydrolysis with their cellular level mechanism in SH-SY5Y cells

(2021) Eui-Hyoun Ma et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Reversal of brain aging by targeting telomerase: A nutraceutical approach

(2021) Dimitris Tsoukalas et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy

(2021) Javad Sharifi-Rad et al.   NEUROCHEMICAL RESEARCH

Antioxidant and Anti-Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration

(2021) Simone Angeloni et al.   Oxidative Medicine and Cellular Longevity

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

(2021) Javad Sharifi-Rad et al.   Oxidative Medicine and Cellular Longevity

Neuropharmacological Effects of Quercetin: A Literature-Based Review

(2021) Md. Shahazul Islam et al.   Frontiers in Pharmacology

Neuroprotective Natural Products for Alzheimer’s Disease

(2021) Xin Chen et al.   Cells

Therapeutic Potential of Neoechinulins and Their Derivatives: An Overview of the Molecular Mechanisms Behind Pharmacological Activities

(2021) Javad Sharifi-Rad et al.   Frontiers in Nutrition

Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2

(2021) Daniela Calina et al.   Life-Basel

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review

(2021) Danko Jeremic et al.   AGEING RESEARCH REVIEWS

In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation

(2021) Rajib Hossain et al.   Chinese Journal of Integrative Medicine

Characterization and purification of β−secretase inhibitory peptides fraction from sea cucumber (Holothuria spinifera) enzymatic hydrolysates

(2021) Anuruddhika Udayangani Rathnayake et al.   PROCESS BIOCHEMISTRY

Biological activity and toxicity of plant nutraceuticals: an overview

(2021) Mercedes Taroncher et al.   Current Opinion in Food Science

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

(2020) Luke Cassidy et al.   COMPLEMENTARY THERAPIES IN MEDICINE

The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model

(2020) Anca Oana Docea et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isolation, Characterization, and Possible Anti‐Alzheimer's Disease Activities of Bisabolane‐Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

(2020) Pei‐Qian Wu et al.   CHEMISTRY & BIODIVERSITY

Natural antioxidants' effects on endoplasmic reticulum stress-related diseases

(2020) Laura María Reyes-Fermín et al.   FOOD AND CHEMICAL TOXICOLOGY

Neuroinflammation in Pathogenesis of Alzheimer's Disease: Phytochemicals as Potential Therapeutics

(2020) Alexander Vaiserman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway

(2020) Lijuan Gao et al.   Drug Design Development and Therapy

Comparative Kinetics of Acetyl- and Butyryl-Cholinesterase Inhibition by Green Tea Catechins|Relevance to the Symptomatic Treatment of Alzheimer’s Disease

(2020) Edward J. Okello et al.   Nutrients

α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2

(2020) Bingxu Huang et al.   Frontiers in Pharmacology

Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

(2020) Lu Wang et al.   Translational Neurodegeneration

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

(2020) Mehdi Sharifi-Rad et al.   Journal of Clinical Medicine

From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

(2020) Claudia Albertini et al.   MEDICINAL RESEARCH REVIEWS

Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer′s Disease Therapy

(2020) Agnieszka Zagórska et al.   MOLECULES

Genistein and Galantamine Combinations Decrease β-Amyloid Peptide (1–42)–Induced Genotoxicity and Cell Death in SH-SY5Y Cell Line: an In Vitro and In Silico Approach for Mimic of Alzheimer’s Disease

(2020) Willian Orlando Castillo et al.   NEUROTOXICITY RESEARCH

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

(2020) Saba Naqvi et al.   Frontiers in Neuroscience

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

(2020) Mehdi Sharifi-Rad et al.   Frontiers in Physiology

The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies

(2020) Daniela Calina et al.   Journal of Clinical Medicine

A Perspective on Emerging Therapeutic Interventions for COVID-19

(2020) Muhammad Torequl Islam et al.   Frontiers in Public Health

Recent advances, approaches and challenges in targeting pathways for potential COVID-19 vaccines development

(2020) Daniela Calina et al.   IMMUNOLOGIC RESEARCH

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

(2020) Junmin Zhang et al.   MEDICINAL RESEARCH REVIEWS

Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique

(2020) Gabriella Sousa Santos et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Repurposed agents in the Alzheimer’s disease drug development pipeline

(2020) Justin Bauzon et al.   Alzheimers Research & Therapy

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

(2020) Bahare Salehi et al.   Frontiers in Pharmacology

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

(2020) Javad Sharifi-Rad et al.   Frontiers in Pharmacology

COVID-19 vaccines: ethical framework concerning human challenge studies

(2020) Daniela Calina et al.   DARU-Journal of Pharmaceutical Sciences

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Molecular Docking Studies of Coumarins Isolated from Extracts and Essential Oils of Zosima absinthifolia Link as Potential Inhibitors for Alzheimer’s Disease

(2019) Songul Karakaya et al.   MOLECULES

The Alzheimer’s Disease Clinical Spectrum

(2019) Alireza Atri   MEDICAL CLINICS OF NORTH AMERICA

Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies

(2019) Ning-Ning Yuan et al.   BMC Complementary and Alternative Medicine

Current and Future Treatments in Alzheimer's Disease

(2019) Alireza Atri   SEMINARS IN NEUROLOGY

How plausible is an Alzheimer’s disease vaccine?

(2019) Ramón Cacabelos   Expert Opinion on Drug Discovery

Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives

(2019) Dimitris Tsoukalas et al.   Molecular Medicine Reports

Rationale for the development of an Alzheimer’s disease vaccine

(2019) Ping Kwan et al.   Human Vaccines & Immunotherapeutics

Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer’s disease induced by β-amyloid 1-42 peptide in aged female mice

(2019) Renata Giacomeli et al.   BRAIN RESEARCH

Questions EMERGE as Biogen claims aducanumab turnaround

(2019) Robert Howard et al.   Nature Reviews Neurology

Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts

(2019) Khayrya A. Youssif et al.   PLoS One

Editorial: Natural Products-Based Drugs: Potential Therapeutics Against Alzheimer’s Disease and Other Neurological Disorders

(2019) Muhammad Ayaz et al.   Frontiers in Pharmacology

Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds

(2019) Maria João Ramalho et al.   Drug Delivery and Translational Research

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

(2019) Antonella Amato et al.   Antioxidants

Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease

(2019) Taro Saito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chlorogenic acid (CGA): A pharmacological review and call for further research

(2018) Muhammad Naveed et al.   BIOMEDICINE & PHARMACOTHERAPY

Nutraceuticals: opening the debate for a regulatory framework

(2018) Antonello Santini et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Caffeic acid and chlorogenic acid: Evaluation of antioxidant effect and inhibition of key enzymes linked with hypertension

(2018) Odunayo Michael Agunloye et al.   JOURNAL OF FOOD BIOCHEMISTRY

XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology

(2018) Kuan-Chung Cheng et al.   MOLECULAR NEUROBIOLOGY

Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

(2018) Jan Korábečný et al.   NEUROSCIENCE

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial

(2018) Ana-María Lacosta et al.   Alzheimers Research & Therapy

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Phytol: A review of biomedical activities

(2018) Muhammad Torequl Islam et al.   FOOD AND CHEMICAL TOXICOLOGY

Roasted Coffee Reduces β-Amyloid Production by Increasing Proteasomal β-Secretase Degradation in Human Neuroblastoma SH-SY5Y Cells

(2018) Kazuya Fukuyama et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

(2018) Kazuki Ide et al.   MOLECULES

Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics

(2018) Jurre den Haan et al.   Acta Neuropathologica Communications

Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines

(2018) Adel A. Gomaa et al.   CYTOKINE

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease

(2018) Petr Novak et al.   Alzheimers Research & Therapy

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

(2018) Chiara Zucchella et al.   Frontiers in Neurology

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y

(2018) Stephane J.de M. Escobar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Biogenic synthesis of gold nanoparticles from Terminalia arjuna bark extract: assessment of safety aspects and neuroprotective potential via antioxidant, anticholinesterase, and antiamyloidogenic effects

(2017) Natarajan Suganthy et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease

(2017) Lina Clara Gayoso e Ibiapina Moreno et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer’s-Related Pathology via HMGB1 Inhibition

(2017) Zhong-Hong Kong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer's Disease: Systematic Review and Network Metaanalysis

(2017) Andrea C. Tricco et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway

(2017) Jing Wang et al.   Marine Drugs

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Terpenoids as promising therapeutic molecules against Alzheimer’s disease: amyloid beta- and acetylcholinesterase-directed pharmacokinetic and molecular docking analyses

(2017) Manika Awasthi et al.   MOLECULAR SIMULATION

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

(2017) Prashamsa Koirala et al.   Asian Pacific Journal of Tropical Medicine

Volatile terpenoids as potential drug leads in Alzheimer’s disease

(2017) Karolina A. Wojtunik-Kulesza et al.   Open Chemistry

NEUROPROTECTIVE EFFECT OF AMORPHOPHALLUS CAMPANULATUS IN STZ INDUCED ALZHEIMER RAT MODEL

(2016) Dong Chen   African Journal of Traditional Complementary and Alternative Medicines

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells

(2016) Dahong Yao et al.   BIOORGANIC CHEMISTRY

Defining ‘nutraceuticals’: neither nutritious nor pharmaceutical

(2016) Jeffrey K. Aronson   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells

(2016) Chang-Mu Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective effect of catechin rich extract of Rhizophora mucronata against β-amyloid-induced toxicity in PC12 cells

(2016) Natarajan Suganthy et al.   Journal of Applied Biomedicine

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

(2016) Manuela Pennisi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

(2016) Rosaliana Libro et al.   MOLECULES

Antioxidative stress effect of epicatechin and catechin induced by Aβ25–35 in rats and use of the electrostatic potential and the Fukui function as a tool to elucidate specific sites of interaction

(2016) Trinidad Cruz-González et al.   NEUROPEPTIDES

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

(2016) Mackenzie M. Shipley et al.   Jove-Journal of Visualized Experiments

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

(2016) Venkatesh Mallikarjun et al.   EBioMedicine

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells

(2015) Hee Ra Park et al.   BMC Complementary and Alternative Medicine

Nutraceuticals and Functional Foods: The Foods for the Future World

(2015) Khalid Gul et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nanoparticle technology for treatment of Parkinson's disease: the role of surface phenomena in reaching the brain

(2015) Gerardo Leyva-Gómez et al.   DRUG DISCOVERY TODAY

On the generation of OH· radical species from H2O2 by Cu(I) amyloid beta peptide model complexes: a DFT investigation

(2015) Tommaso Prosdocimi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25-35-induced neurotoxicity in human neuroblastoma cells

(2015) Navrattan Kaur et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study

(2015) Muhammad Ayaz et al.   Lipids in Health and Disease

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms inin vitroandin vivomodels of Alzheimer's disease

(2015) Miho Yoshida Yamakawa et al.   NUTRITIONAL NEUROSCIENCE

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

(2015) Ramu Venkatesan et al.   Biomed Research International

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Dose-Dependent Inhibition of BACE-1 by the Monoterpenoid 2,3,4,4-Tetramethyl-5-methylenecyclopent-2-enone in Cellular and Mouse Models of Alzheimer’s Disease

(2014) Rita Videira et al.   JOURNAL OF NATURAL PRODUCTS

Osthole, a Natural Coumarin Improves Cognitive Impairments and BBB Dysfunction After Transient Global Brain Ischemia in C57 BL/6J Mice: Involvement of Nrf2 Pathway

(2014) ZiWei Chen et al.   NEUROCHEMICAL RESEARCH

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease

(2013) Shereen K Ali et al.   BMC Complementary and Alternative Medicine

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1–42) rat model of Alzheimer's disease

(2013) Oana Cioanca et al.   PHYSIOLOGY & BEHAVIOR

Neuroprotective effects of inhaled lavender oil on scopolamine-induced dementia via anti-oxidative activities in rats

(2013) Monica Hancianu et al.   PHYTOMEDICINE

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl

(2012) Miguel Arruda et al.   MOLECULES

Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

(2012) Ganiyu Oboh et al.   NEUROCHEMICAL RESEARCH

6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

(2012) Sang Keun Ha et al.   NEUROPHARMACOLOGY

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH

(2011) Yusaku Miyamae et al.   CYTOTECHNOLOGY

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation: Modulation by flavonoids and mechanisms of action

(2011) Jeremy P.E. Spencer et al.   MOLECULAR ASPECTS OF MEDICINE

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

(2011) Hong-Fang Ji et al.   MOLECULES

Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

(2010) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fruit polyphenols, immunity and inflammation

(2010) Javier González-Gallego et al.   BRITISH JOURNAL OF NUTRITION

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice

(2010) Seung-Hwan Kwon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1

(2010) J. Han et al.   NEUROSCIENCE

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

(2009) Ping-Hsiao Shih et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Review of the Application and Pharmacological Properties of α-Bisabolol and α-Bisabolol-Rich Oils

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