FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

(2018) Yan Zhou et al.   Frontiers in Aging Neuroscience

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

(2017) Sergey O. Bachurin et al.   MEDICINAL RESEARCH REVIEWS

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Assessing the Immunogenicity of Biopharmaceuticals

(2016) Carlos Pineda et al.   BIODRUGS

Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy

(2016) Ivana Zimova et al.   JOURNAL OF ALZHEIMERS DISEASE

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease

(2015) Michael G. Agadjanyan et al.   Alzheimers & Dementia

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Assessing atrophy measurement techniques in dementia: Results from the MIRIAD atrophy challenge

(2015) David M. Cash et al.   NEUROIMAGE

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study

(2012) Jennifer L Whitwell et al.   LANCET NEUROLOGY

Within-subject template estimation for unbiased longitudinal image analysis

(2012) Martin Reuter et al.   NEUROIMAGE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Safety profile of Alzheimer's disease populations in Alzheimer's Disease Neuroimaging Initiative and other 18-month studies

(2011) David B. Henley et al.   Alzheimers & Dementia

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project

(2010) A. Wimo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Highly accurate inverse consistent registration: A robust approach

(2010) Martin Reuter et al.   NEUROIMAGE

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

(2009) Norbert Zilka et al.   ACTA NEUROPATHOLOGICA

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

(2009) Bruno Vellas et al.   Current Alzheimer Research

A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus

(2008) J. Barnes et al.   NEUROIMAGE