Osthole, a Natural Coumarin Improves Cognitive Impairments and BBB Dysfunction After Transient Global Brain Ischemia in C57 BL/6J Mice: Involvement of Nrf2 Pathway

Blood-brain barrier and traumatic brain injury

(2013) José Luís Alves   JOURNAL OF NEUROSCIENCE RESEARCH

Cerebroprotective Effect ofMoringa oleiferaagainst Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion

(2013) Woranan Kirisattayakul et al.   Oxidative Medicine and Cellular Longevity

Moderate Hypoxia Followed by Reoxygenation Results in Blood-Brain Barrier Breakdown via Oxidative Stress-Dependent Tight-Junction Protein Disruption

(2013) Christoph M. Zehendner et al.   PLoS One

Osthole improves acute lung injury in mice by up-regulating Nrf-2/thioredoxin 1

(2013) Xiang-Jun Chen et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats

(2012) Li Yao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Achyranthes japonica exhibits anti-inflammatory effect via NF-κB suppression and HO-1 induction in macrophages

(2012) Soo Young Bang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

(2012) Silvia Manzanero et al.   NEUROCHEMISTRY INTERNATIONAL

Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats

(2012) K.P. Mansoorali et al.   PHYTOMEDICINE

Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways

(2011) Yu Mi Ha et al.   APOPTOSIS

Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

(2011) C. Escartin et al.   JOURNAL OF NEUROSCIENCE

lschémie cérébrale

(2011) Pascal Benquet et al.   M S-MEDECINE SCIENCES

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus

(2010) Hai-Jie Ji et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production

(2010) Wen-Bo Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin

(2009) Xiaohong Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

(2009) Volodymyr Gerzanich et al.   NATURE MEDICINE

Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain

(2009) Jian-tao Ye et al.   NEUROREPORT

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Blood Brain Barrier in Hypoxic-Ischemic Conditions

(2008) C. Kaur et al.   CURRENT NEUROVASCULAR RESEARCH

Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7

(2008) Tomonori Nakamura et al.   Journal of Natural Medicines

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

New therapeutic targets in the neurovascular pathway in Alzheimer’s disease

(2008) Berislav V. Zlokovic   Neurotherapeutics