Review
Cell Biology
Bipul Ray, Arehally M. Mahalakshmi, Sunanda Tuladhar, Abid Bhat, Asha Srinivasan, Christophe Pellegrino, Anbarasu Kannan, Srinivasa Rao Bolla, Saravana Babu Chidambaram, Meena Kishore Sakharkar
Summary: Parkinson's disease is characterized by the aggregation of α-synuclein protein, forming Lewy bodies, with several mutations in α-synuclein identified as potential causes. The spread of pathological α-synuclein between cells is believed to play a significant role in the development of the disease. It has been suggested that the pathology of Parkinson's disease may originate in the gastrointestinal tract and spread to the brain via the vagus nerve.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Keelan Jagaran, Moganavelli Singh
Summary: Parkinson's disease is a debilitating neurodegenerative disorder with limited treatment options. Nanomedicine, specifically lipid nanoparticles, shows promise as a therapeutic nanocarrier for PD due to their ability to target the brain and deliver drugs. The potential of lipid nanoparticles in PD treatment is evident in their formulations as vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Multidisciplinary Sciences
Safa Salim, Fatima Ahmad, Ayesha Banu, Farhan Mohammad
Summary: Parkinson's disease (PD) is caused by ⍺-synuclein aggregation-mediated dopaminergic neuronal loss, leading to motor and non-motor symptoms. Inflammation-mediated oxidative stress, mitochondrial dysfunction, and cytokine-induced toxicity are believed to be involved in the neuronal damage and loss associated with PD. The gut and brain have been found to play important roles in the pathogenesis of PD. This review summarizes the impact of gut microbiome alterations on PD pathogenesis and proposes early interventions and dietary modifications as potential protective measures against PD development.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Integrative & Complementary Medicine
Jaeyoung Park, Ju-Young Oh, Hi -Joon Park
Summary: This review examines the similarities in the mechanisms of action between acupuncture and neuromodulation and explores the potential role of acupuncture in the treatment of Parkinson's disease. The study suggests that acupuncture can alleviate Parkinson's symptoms by modulating inflammation and brain functional connectivity, similar to the effects of neuromodulation. Based on these shared mechanisms, acupuncture may offer new treatment options as personalized neuromodulating therapies for Parkinson's disease patients.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Clinical Neurology
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Summary: This study investigated the effects of encoding type, medication, and subthalamic nucleus deep brain stimulation (STN-DBS) on memory-guided movements in Parkinson's disease (PD). The findings revealed that encoding type influenced reaching performance and deficits in PD, medication had differential effects depending on the encoding type, and STN-DBS was superior to medication in increasing amplitude and velocity. The study provides valuable insights into the understanding of memory-guided movements in PD and the effects of different treatments.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Alessio Fasano, Alberto Mazzoni, Egidio Falotico
Summary: Parkinson's disease affects the brain's motor circuits, causing general slowness and paucity of movements. Studies have focused on abnormalities in movement initiation, planning, and execution, linking them to abnormal preparatory brain activity. The role of the basal ganglia in motor control, and the unresolved questions regarding speed-accuracy tradeoff and feedback control, remain key areas of investigation.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Engineering, Biomedical
Yifei Gao, Yuxue Cheng, Jiapeng Chen, Danmin Lin, Chao Liu, Ling-Kun Zhang, Liang Yin, Runcai Yang, Yan-Qing Guan
Summary: In this study, MgOp@PPLP nanoparticles were developed to overcome the blood-brain barrier and be used for gene therapy and antioxidant therapy in Parkinson's disease. These nanoparticles showed good neuroprotective effects in PD models.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Md Marufur Rahman Moni, Mst Marium Begum, Md Sahab Uddin, Ghulam Md Ashraf
Summary: Parkinson's disease is a progressive neurodegenerative disorder with increasing occurrence. Conventional treatment has side-effects and low bioavailability. Nanotechnology shows great promise in improving treatment efficacy and reducing side-effects for PD patients.
CURRENT DRUG METABOLISM
(2021)
Article
Medicine, Research & Experimental
Mahmoud A. Alomari, Hanan Khalil, Omar F. Khabour, Karem H. Alzoubi
Summary: The study revealed a relationship between BDNF and lipid profile, suggesting the importance of BDNF for lipid metabolism in patients with Parkinson's disease.
Review
Endocrinology & Metabolism
Sara Ayman Moustafa, Shrouk Mohamed, Abdelhameed Dawood, Jihan Azar, Ekramy Elmorsy, Noura A. M. Rizk, Mohamed Salama
Summary: Parkinson's disease is a common progressive neurodegenerative disease characterized by the presence of alpha-synuclein aggregates in the brain and enteric nervous system. Dysbiosis in gut microbiota may be an early sign of PD, leading to potential therapeutic strategies through the gut-brain axis communication system.
METABOLIC BRAIN DISEASE
(2021)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Tianqi Nie, Zhiyu He, Jinchang Zhu, Kuntao Chen, Gregory P. Howard, Jesus Pacheco-Torres, Il Minn, Pengfei Zhao, Zaver M. Bhujwalla, Hai-Quan Mao, Lixin Liu, Yongming Chen
Summary: A non-invasive method involving sub-50 nm nanoparticles loaded with L-DOPA was successfully developed to deliver the drug to the brain through brain-lymphatic vasculature. Pharmacodynamics analysis in a PD rat model showed significant improvement in dopamine and tyrosine hydroxylase levels, along with movement disorders and cerebral oxidative stress. The formulation exhibited high biocompatibility and holds promise for clinical treatment of Parkinson's disease.
Article
Neurosciences
Miranda J. Munoz, Rishabh Arora, Yessenia M. Rivera, Quentin H. Drane, Gian D. Pal, Leo Verhagen Metman, Sepehr B. Sani, Joshua M. Rosenow, Lisa C. Goelz, Daniel M. Corcos, Fabian J. David
Summary: This study found that medication worsens saccade performance and benefits reaching performance, while STN-DBS benefits both saccade and reaching performance. These findings suggest potential physiological changes due to treatment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Immunology
Laura E. Martinez-Gomez, Carlos Martinez-Armenta, Daniel Medina-Luna, Maria Luisa Ordonez-Sanchez, Tere Tusie-Luna, Silvestre Ortega-Pena, Brigida Herrera-Lopez, Carlos Suarez-Ahedo, Guadalupe Elizabeth Jimenez-Gutierrez, Alberto Hidalgo-Bravo, Paola Vazquez-Cardenas, Rosa P. Vidal-Vazquez, Juan P. Ramirez-Hinojosa, Pilar Miyoko Martinez Matsumoto, Gilberto Vargas-Alarcon, Rosalinda Posadas-Sanchez, Jose-Manuel Fragoso, Felipe de J. Martinez-Ruiz, Dulce M. Zayago-Angeles, Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Adriana Martinez-Cuazitl, Javier Andrade-Alvarado, Julio Granados, Luis Ramos-Tavera, Maria del Carmen Camacho-Rea, Yayoi Segura-Kato, Josemanuel Rodriguez-Perez, Roberto Coronado-Zarco, Rafael Franco-Cendejas, Luis Esau Lopez-Jacome, Jonathan J. Magana, Marcela Vela-Amieva, Carlos Pineda, Gabriela Angelica Martinez-Nava, Alberto Lopez-Reyes
Summary: This study found that TLR7 and MyD88 gene polymorphisms are associated with the severity of COVID-19 in SARS-CoV-2 infected patients. The results suggest that certain genotypes may be correlated with severe, critical, and deceased outcomes.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Neurosciences
Hector Hernandez-Parra, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez, Manuel Gonzalez-Del Carmen, Maykel Gonzalez-Torres, Sheila I. Pena-Corona, Benjamin Floran, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Various neurological symptoms, including stroke, ataxia, meningitis, encephalitis, and cognitive impairment, have been observed in COVID-19 patients infected with SARS-CoV-2. These symptoms are associated with the virus's ability to enter the Central Nervous System (CNS) and can lead to severe consequences. This review explores the mechanisms by which SARS-CoV-2 interacts with the blood-brain barrier (BBB) and discusses the implications for drug delivery to the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Sheila I. Pena-Corona, Hector Hernandez-Parra, Sergio A. Bernal-Chavez, Nestor Mendoza-Munoz, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Hernan Cortes, Dilek Arslan Atessahin, Solomon Habtemariam, Zainab M. Almarhoon, Ahmad Faizal Abdull Razis, Babagana Modu, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: Cancer is a major cause of death worldwide and poses significant clinical, social, and financial burdens. Traditional cancer chemotherapies have limitations, and there is a need for bioactive anticancer compounds. Neopeltolide, a macrolide derived from deep-water sponges, shows promise as a novel drug for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemical Research Methods
Sergio A. Bernal-Chavez, Alejandra Romero-Montero, Hector Hernandez-Parra, Sheila I. Pena-Corona, Maria L. Del Prado-Audelo, Sergio Alcala-Alcala, Hernan Cortes, Lashyn Kiyekbayeva, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: The freeze-thaw method is commonly used in the processing and handling of drugs to enhance their stability and obtain pharmaceutical applications. However, the use of this method is limited by certain characteristics and requires optimization of process conditions and variables. Current research focuses on enhancing formulations, process optimization, and the use of freeze-thaw methods. This review discusses the impact of the freeze-thaw process on the physical, mechanical, and chemical properties of pharmaceutical applications, along with challenges and opportunities in development.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Review
Biochemical Research Methods
Samanta Castaneda-Rodriguez, Maykel Gonzalez-Torres, Rosa Maria Ribas-Aparicio, Maria Luisa Del Prado-Audelo, Gerardo Leyva-Gomez, Eda Soenmez Gurer, Javad Sharifi-Rad
Summary: Tissue engineering and regenerative medicine aim to develop materials that can replace, restore, or enhance organs or tissues, and improve cellular capacity for proliferation, migration, and differentiation. Renewable resources have been utilized to produce environmentally friendly biomaterials, including the biodegradable polymer poly(lactic acid) (PLA). In combination with other polymers, PLA can be modified to create biomaterials with suitable properties for tissue engineering applications. This review focuses on the advancements in modified PLA as tissue engineering materials, highlighting efforts to overcome limitations such as biological inertness, low cell adhesion, and slow degradation rate, and develop enhanced alternative biomaterials.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jocelyn C. Ayala-Fuentes, Maryam Soleimani, Jonathan Javier Magana, Jose Mario Gonzalez-Meljem, Rocio Alejandra Chavez-Santoscoy
Summary: Researchers developed a novel hybrid inulin-soy protein nanoparticle formulation loaded with (-)-epicatechin and quercetin to enhance their bioavailability. The nanoparticles exhibited desired size and charge, and demonstrated excellent performance in terms of release and digestion. Additionally, the nanoparticles exhibited inhibitory effects on Caco-2 cells, highlighting their potential in improving the bioavailability of bioactive compounds.
Article
Pharmacology & Pharmacy
Isaac H. Caballero-Floran, Hernan Cortes, Fabiola V. Borbolla-Jimenez, Carla D. Floran-Hernandez, Maria L. Del Prado-Audelo, Jonathan J. Magana, Benjamin Floran, Gerardo Leyva-Gomez
Summary: This study proposes the use of polyethylene glycol 400 (PEG) and trehalose as a surface modification technique to improve PLGA-based nanoparticles as drug carriers for neurons. The combination of PEG and trehalose enhances the hydrophilicity of the nanoparticles and promotes their cellular internalization. Through optimization using central composite design, PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not significantly increase their size. The nanoparticles showed high curcumin entrapment efficiency and a controlled release profile.
Review
Biology
Edgar Yebran Villegas-Vazquez, Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Miguel Rodriguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Perez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez
Summary: Lithium, an anti-cancer agent, shows potential in inducing apoptosis, autophagy, and inhibiting tumor growth. It also plays a role in tumor regulation and synergizes with standard cancer therapies. Additionally, lithium has neuroprotective effects and enhances anti-tumor activities in nano-sized form. However, its therapeutic activities depend on various factors. This review emphasizes the importance of repurposing lithium as a therapeutic agent and highlights its molecular mechanisms.
Review
Chemistry, Applied
Nestor Mendoza-Munoz, Gerardo Leyva-Gomez, Elizabeth Pinon-Segundo, Maria L. Zambrano-Zaragoza, David Quintanar-Guerrero, Maria Luisa Del Prado Audelo, Zaida Urban-Morlan
Summary: The term biopolymer refers to materials obtained by chemically modifying natural biological substances or producing them through biotechnological processes. They are biodegradable, biocompatible and non-toxic. Due to these advantages, biopolymers have wide applications in cosmetic formulations and have emerged as essential ingredients with various functions.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Biochemical Research Methods
Sergio Alberto Bernal-Chavez, Sergio Alcala-Alcala, Zainab M. Almarhoon, Aknur Turgumbayeva, Eda Sonmez Gurer, Ma. de los Dolores Campos-Echeverria, Hernan Cortes, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: In this study, an ultra-stretchable and self-healing hydrogel was developed by adding PolyOX to cationic guar gum hydrogels. The optimized hydrogel exhibited semi-crystalline structure, high stretchability, and excellent self-healing properties, making it suitable for various applications in tissue engineering, drug delivery, and food storage.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Fabiola V. Borbolla-Jimenez, Sheila I. Pena-Corona, Sonia J. Farah, Maria Teresa Jimenez-Valdes, Emiliano Pineda-Perez, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Jonathan J. Magana, Gerardo Leyva-Gomez
Summary: Wound healing is a complex process involving four phases: hemostasis, inflammation, proliferation, and remodeling. Polymeric films have been widely used as wound dressings due to their biocompatibility, low immunogenicity, ease of application, and gas exchange capabilities. Among various methods for designing polymeric films, solvent casting is a reliable and cost-effective technique. This review focuses on polymeric dressings obtained using solvent casting, discussing the manufacturing factors necessary for effective wound dressing performance.
Article
Health Care Sciences & Services
Hernan Cortes, Lizbeth Carino-Calvo, Octavio D. Reyes-Hernandez, Martin Rojas-Marquez, Jonathan J. Magana, Pablo A. Vizcaino-Dorado, Edgar Y. Villegas-Vazquez, Laura Itzel Quintas-Granados, Elizabeth Jimenez-Islas, Valeria A. Cortes-Mollinedo, Gerardo Leyva-Gomez, Manuel Gonzalez-Del Carmen
Summary: This study found that patients with lamellar ichthyosis have higher levels of anxiety and depression, which may be associated with suicidal risk. Therefore, the collaborative involvement of skin and mental health professionals is necessary to manage these patients appropriately.
Article
Neurosciences
Laura Bannach Jardim, Ali Hasan, Sheng-han Kuo, Jonathan Javier Magana, Marcondes Franca, Wilson Marques, Claudia Camejo, Luiz Carlos Santana-da-Silva, Emilia Embirucu Leao, Gisele Espindola, Francisca Canals, Marcelo Miranda, Igor Salvatierra, Mario Cornejo-Olivas, Juan Fernandez-Ruiz, Pedro Braga-Neto, David Jose Davila-Ortiz de Montellano, Luis Leonardo Flores-Lagunes, Nicolas Dupre, Bernard Brais, Fernando Regla Vargas, Clecio Godeiro, Leo Coutinho, Helio G. Teive, Marcelo Kaufmann, Paula Saffie, Gabriel Vasata Furtado, Maria Luiza Saraiva-Pereira, Orlando Barsottini, Jose Luiz Pedroso, Roberto Rodriguez-Labrada, Luis Velazquez-Perez, Christopher Gomez
Summary: Little is known about access to healthcare for rare disease carriers. The Pan American Hereditary Ataxia Network conducted a survey to explore care for hereditary ataxias in the Americas and the Caribbean. The results revealed significant disparities and the need for more diagnostic tools, guidelines, and professional training.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
