BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

E3 ligase Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

(2018) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Classic and Novel Signaling Pathways Involved Cancer: Targeting the NF-κB and Syk Signaling Pathways

(2018) Cong Tang et al.   Current Stem Cell Research & Therapy

Branched Chain Amino Acids

(2018) Michael Neinast et al.   Annual Review of Physiology

Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis

(2018) Xiao-Mei Yang et al.   GASTROENTEROLOGY

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain

(2017) Amélie Wallenhammar et al.   PLoS One

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

(2016) Yi-Ping Wang et al.   MOLECULAR CELL

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors

(2016) Hongfeng Deng et al.   ACS Medicinal Chemistry Letters

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

(2015) Fuming Li et al.   CANCER CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

(2015) Hong-Bin Yang et al.   Nature Communications

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

(2012) Jian Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control

(2012) Vincent C. Chen et al.   JOURNAL OF PROTEOME RESEARCH

Pancreatic ductal cells in development, regeneration, and neoplasia

(2011) Maximilian Reichert et al.   JOURNAL OF CLINICAL INVESTIGATION

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH