Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

Metabolic regulation of CAR T cell function by the hypoxic microenvironment in solid tumors

(2019) Anna Schurich et al.   Immunotherapy

Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet

(2019) Michael Rosenbaum et al.   Obesity

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

OUP accepted manuscript

(2018)   JOURNAL OF NUTRITION

Anti-Diabetic Drugs: Cure or Risk Factors for Cancer?

(2018) Jeny Laskar et al.   PATHOLOGY & ONCOLOGY RESEARCH

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells

(2018) Qian Mu et al.   OncoTargets and Therapy

Efficacy of metformin in combination with immune checkpoint inhibitors (anti-PD-1/anti-CTLA-4) in metastatic malignant melanoma

(2018) Muhammad Zubair Afzal et al.   Journal for ImmunoTherapy of Cancer

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Time-restricted feeding mitigates high-fat diet–enhanced mammary tumorigenesis in MMTV-PyMT mice

(2018) S. Sundaram et al.   NUTRITION RESEARCH

The emerging role of ketogenic diets in cancer treatment

(2018) Rainer Johannes Klement   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Is Resveratrol a Cancer Immunomodulatory Molecule?

(2018) Ly Quoc Trung et al.   Frontiers in Pharmacology

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape

(2017) Leisha A. Emens et al.   EUROPEAN JOURNAL OF CANCER

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action

(2017) Shimaa Ibrahim Abdelmonym Mohamed et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells

(2017) Amy Lyons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

(2017) Sun Hye Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans

(2017) J. Luis Espinoza et al.   Oxidative Medicine and Cellular Longevity

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

(2016) Danielle M. Lussier et al.   BMC CANCER

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Obesity and tumor growth

(2016) Christopher Wright et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

(2016) C. Vernieri et al.   Cancer Discovery

Natural Polyphenols for Prevention and Treatment of Cancer

(2016) Yue Zhou et al.   Nutrients

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer

(2016) R J Klement et al.   Oncogenesis

Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis

(2016) Rainer J. Klement et al.   PLoS One

Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

(2016) Yalan Chen et al.   Scientific Reports

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Pharmacologic Therapy of Diabetes and Overall Cancer Risk and Mortality: A Meta-Analysis of 265 Studies

(2015) Lang Wu et al.   Scientific Reports

Combinatorial Strategies for the Induction of Immunogenic Cell Death

(2015) Lucillia Bezu et al.   Frontiers in Immunology

The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link

(2015) Laura W. Bowers et al.   Frontiers in Endocrinology

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model

(2015) Raphael Johannes Morscher et al.   PLoS One

Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging

(2014) Michelle Farazi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis

(2014) Mengmeng Lv et al.   PLoS One

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

(2014) Bryan G. Allen et al.   Redox Biology

Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts

(2013) B. G. Allen et al.   CLINICAL CANCER RESEARCH

Selectively starving cancer cells through dietary manipulation: methods and clinical implications

(2013) Brittany A Simone et al.   Future Oncology

Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors

(2012) Liangshan Hu et al.   CANCER BIOLOGY & THERAPY

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Anti-inflammatory Effects of Resveratrol and Its Potential Use in Therapy of Immune-mediated Diseases

(2012) Urban Švajger et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Resveratrol Prevents Endothelial Cells Injury in High-Dose Interleukin-2 Therapy against Melanoma

(2012) Hongbing Guan et al.   PLoS One

The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model

(2011) Brenda L. Soto et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics

(2011) L. M. Howells et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors

(2011) Soner Dogan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

(2010) H.-H. S. Chow et al.   Cancer Prevention Research

Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

(2010) C. Lee et al.   CANCER RESEARCH

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice

(2008) Krista A. Varady et al.   NUTRITION