Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

(2019) Priya Rangan et al.   Cell Reports

Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF4E/PUMA pathway

(2019) Huanan Wang et al.   CANCER GENE THERAPY

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

Functional reprogramming of regulatory T cells in the absence of Foxp3

(2019) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

(2019) Zheng Zhong et al.   ONCOGENE

Fasting and rapamycin: diabetes versus benevolent glucose intolerance

(2019) Mikhail V. Blagosklonny   Cell Death & Disease

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals

(2019) Xiaoyu Chen et al.   ONCOGENE

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

(2019) Yuan Fang et al.   Nature Communications

Caloric restriction effects on liver mTOR signaling are time-of-day dependent

(2018) Richa Tulsian et al.   Aging-US

Squalene Synthase Deficiency: Clinical, Biochemical, and Molecular Characterization of a Defect in Cholesterol Biosynthesis

(2018) David Coman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SREBP2 contributes to cisplatin resistance in ovarian cancer cells

(2018) Lei Zheng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Advances in CRC Prevention: Screening and Surveillance

(2018) Evelien Dekker et al.   GASTROENTEROLOGY

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Starvation, Stress Resistance, and Cancer

(2018) Roberta Buono et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

(2018) Mehdi Dehghani et al.   International Journal of Genomics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury

(2016) Christine R. Mauro et al.   JOURNAL OF VASCULAR SURGERY

Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study

(2016) James C Yao et al.   LANCET

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

(2016) C. Vernieri et al.   Cancer Discovery

Prolonged Nightly Fasting and Breast Cancer Prognosis

(2016) Catherine R. Marinac et al.   JAMA Oncology

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Colorectal cancer screening: a global overview of existing programmes

(2015) Eline H Schreuders et al.   GUT

Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice

(2015) Lauren T Robertson et al.   JOURNAL OF NUTRITION

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

(2015) Giovanna Bianchi et al.   Oncotarget

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial

(2012) David Neal Franz et al.   LANCET

The Warburg effect: Insights from the past decade

(2012) Mohita Upadhyay et al.   PHARMACOLOGY & THERAPEUTICS

Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer

(2012) Y Fukuma et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway

(2009) R Do et al.   CLINICAL GENETICS

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE