The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

(2022) Xiwei Wang et al.   Journal for ImmunoTherapy of Cancer

Molecular Identification of Tumor-Derived Extracellular Vesicles Using Thermophoresis-Mediated DNA Computation

(2021) Yike Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosome-based liquid biopsies in cancer: opportunities and challenges

(2021) W. Yu et al.   ANNALS OF ONCOLOGY

Navigating CAR-T cells through the solid-tumour microenvironment

(2021) Andrew J. Hou et al.   NATURE REVIEWS DRUG DISCOVERY

Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer

(2021) Fei Tian et al.   Nature Communications

CD19 Chimeric Antigen Receptor-Exosome Targets CD19 Positive B-lineage Acute Lymphocytic Leukemia and Induces Cytotoxicity

(2021) Shabirul Haque et al.   Cancers

Cytokine-enhanced cytolytic activity of exosomes from NK Cells

(2021) Yutaka Enomoto et al.   CANCER GENE THERAPY

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

(2021) Lexus R. Johnson et al.   CELL

Exosomes as mediators of intercellular crosstalk in metabolism

(2021) Roi Isaac et al.   Cell Metabolism

Extracellular vesicles derived from CAR-T Cells: A potential therapy for cancer

(2021) Anat Aharon et al.   HUMAN GENE THERAPY

Natural Killer Cell-Derived Extracellular Vesicles: Novel Players in Cancer Immunotherapy

(2021) Feifeng Wu et al.   Frontiers in Immunology

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2021) Zhaogang Yang et al.   Nature Biomedical Engineering

Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

(2021) Abhimanyu Thakur et al.   Bioactive Materials

Effects of Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity and Clinical Applications

(2021) Bo Shao et al.   Frontiers in Cell and Developmental Biology

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

(2020) Gaofeng Liang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tumor‐exocytosed exosome/AIEgen hybrid nano‐vesicles facilitate efficient tumor penetration and photodynamic therapy

(2020) Daoming Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3

(2020) Fan Yang et al.   Cancer Cell International

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

(2020) Bingfeng Zuo et al.   Nature Communications

PD-L1+ exosomes from bone marrow-derived cells of tumor-bearing mice inhibit antitumor immunity

(2020) Yan Sun et al.   Cellular & Molecular Immunology

The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

(2020) Diana Bautista-Sánchez et al.   Molecular Therapy-Nucleic Acids

M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response

(2020) Tong Du et al.   Frontiers in Immunology

Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B

(2020) Hongliang Zhang et al.   CANCER LETTERS

Gene therapy and gene correction: targets, progress, and challenges for treating human diseases

(2020) Matthew R. Cring et al.   GENE THERAPY

Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies

(2020) Qian Xu et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from Vδ2-T cells control Epstein-Barr virus–associated tumors and induce T cell antitumor immunity

(2020) Xiwei Wang et al.   Science Translational Medicine

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

(2020) Na Sun et al.   Nature Communications

Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure compared to recombinant IL-12

(2020) Nuruddeen D. Lewis et al.   MOLECULAR CANCER THERAPEUTICS

Extracellular vesicles: A bright star of nanomedicine

(2020) Peipei Wu et al.   BIOMATERIALS

Surface plasmon resonance imaging-based biosensor for multiplex and ultrasensitive detection of NSCLC-associated exosomal miRNAs using DNA programmed heterostructure of Au-on-Ag

(2020) Wenwen Wu et al.   BIOSENSORS & BIOELECTRONICS

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

(2020) Pengxiang Yang et al.   CELLULAR IMMUNOLOGY

Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

(2019) Jianmei Zou et al.   ANALYTICAL CHEMISTRY

Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

(2019) Qingwei Zhu et al.   Advanced Science

Quantitative and Specific Detection of Exosomal miRNAs for Accurate Diagnosis of Breast Cancer Using a Surface-Enhanced Raman Scattering Sensor Based on Plasmonic Head-Flocked Gold Nanopillars

(2019) Jong Uk Lee et al.   Small

Harnessing Exosomes for the Development of Brain Drug Delivery Systems

(2019) Mengna Zheng et al.   BIOCONJUGATE CHEMISTRY

Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy

(2019) Yu Cao et al.   ACS Nano

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

(2019) Jing Bai et al.   Asian Journal of Pharmaceutical Sciences

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides

(2019) Shu-Wei Wu et al.   Frontiers in Immunology

Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy

(2019) Hong Cheng et al.   BIOMATERIALS

Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma

(2019) Shulin Yu et al.   GUT

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy

(2019) Masamitsu Kanada et al.   MOLECULAR CANCER THERAPEUTICS

Activation of Necroptosis by Engineered Self Tumor-Derived Exosomes Loaded with CRISPR/Cas9

(2019) Diana Gulei et al.   Molecular Therapy-Nucleic Acids

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

(2019) María Sancho-Albero et al.   Nature Catalysis

Immature dendritic cells derived exosomes promotes immune tolerance by regulating T cell differentiation in renal transplantation

(2019) Xin-Lu Pang et al.   Aging-US

Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

(2019) Xiaojing Shi et al.   MOLECULAR THERAPY

CD63-GPC1-Positive Exosomes Coupled with CA19-9 Offer Good Diagnostic Potential for Resectable Pancreatic Ductal Adenocarcinoma

(2019) Etienne Buscail et al.   Translational Oncology

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

(2019) Wenyan Fu et al.   Nature Communications

Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

(2019) Shaojun Pan et al.   BIOMATERIALS

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

(2019) Liuwan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26

(2019) Hongwei Sun et al.   Frontiers in Immunology

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

(2018) Jean M. Lewis et al.   ACS Nano

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Quantitative detection of exosomal microRNA extracted from human blood based on surface-enhanced Raman scattering

(2018) Dandan Ma et al.   BIOSENSORS & BIOELECTRONICS

New insights into the biological impacts of immune cell-derived exosomes within the tumor environment

(2018) Meng Shen et al.   CANCER LETTERS

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

Overview upon miR-21 in lung cancer: focus on NSCLC

(2018) Cecilia Bica-Pop et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

(2018) Xiaochen Wang et al.   JOURNAL OF MEDICAL GENETICS

Self-Assembly of Extracellular Vesicle-like Metal–Organic Framework Nanoparticles for Protection and Intracellular Delivery of Biofunctional Proteins

(2018) Gong Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer

(2018) Xinyi Wang et al.   MOLECULAR THERAPY

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

(2018) Yan Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Clinical utility of circulating non-coding RNAs — an update

(2018) Simone Anfossi et al.   Nature Reviews Clinical Oncology

An ultrasensitive polydopamine bi-functionalized SERS immunoassay for exosome-based diagnosis and classification of pancreatic cancer

(2018) Teng-Da Li et al.   Chemical Science

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

(2018) Naohiro Seo et al.   Nature Communications

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

The emerging roles of exosomes in the modulation of immune responses in cancer

(2018) Paul Kurywchak et al.   Genome Medicine

Exosomal ephrinA2 derived from serum as a potential biomarker for prostate cancer

(2018) Shibao Li et al.   Journal of Cancer

Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

(2018) Margot Zöller et al.   Frontiers in Immunology

Targeting and Therapy of Glioblastoma in a Mouse Model Using Exosomes Derived From Natural Killer Cells

(2018) Liya Zhu et al.   Frontiers in Immunology

Proteomic analysis of human T cell-derived exosomes reveals differential RAS/MAPK signaling

(2018) Inbar Azoulay-Alfaguter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exosomal double-stranded DNA as a biomarker for the diagnosis and preoperative assessment of pheochromocytoma and paraganglioma

(2018) Liang Wang et al.   Molecular Cancer

Novel alternatives to extracellular vesicle-based immunotherapy – exosome mimetics derived from natural killer cells

(2018) Liya Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents

(2018) Rajendran JC Bose et al.   ACS Nano

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

(2018) Wen Liao et al.   Acta Biomaterialia

Natural Killer-derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms.

(2018) Paolo Neviani et al.   CANCER RESEARCH

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

(2018) Qinqin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

(2018) Ni-Ting Chiou et al.   Cell Reports

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

(2018) Joseph Carmicheal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanomedicine Strategies to Target Tumor-Associated Macrophages

(2017) Karin Binnemars-Postma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal proteins as potential markers of tumor diagnosis

(2017) Aichun Li et al.   Journal of Hematology & Oncology

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

(2017) Zhen Lu et al.   JOURNAL OF HEPATOLOGY

Role of Lymphocyte Subsets in the Immune Response to Primary B Cell–Derived Exosomes

(2017) Sarah C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

(2017) Yuichi Kitai et al.   JOURNAL OF IMMUNOLOGY

Macrophage cell-derived exosomes/staphylococcal enterotoxin B against fibrosarcoma tumor

(2017) Elham Behzadi et al.   MICROBIAL PATHOGENESIS

Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide

(2017) Masaki Morishita et al.   MOLECULAR PHARMACEUTICS

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas

(2017) Frederick M Lang et al.   NEURO-ONCOLOGY

Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

(2017) Mitsuo Tsukamoto et al.   ONCOLOGY

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

(2017) Katherine S. Yang et al.   Science Translational Medicine

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Integrins and Exosomes, a Dangerous Liaison in Cancer Progression

(2017) et al.   Cancers

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells

(2017) Lei Li et al.   Scientific Reports

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

(2016) Masaki Morishita et al.   BIOMATERIALS

Extracellular vesicle-mediated suicide mRNA/protein delivery inhibits glioblastoma tumor growth in vivo

(2016) E P Erkan et al.   CANCER GENE THERAPY

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+T-cell responses

(2016) Yingping Xu et al.   IMMUNOLOGY

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

(2016) Scott W. Ferguson et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis

(2016) Z Deng et al.   ONCOGENE

Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer

(2016) Qinyi Zhu et al.   ONCOLOGY REPORTS

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

(2016) Alberto Bosque et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis

(2015) Yiwen You et al.   CANCER SCIENCE

Cross-dressing: an alternative mechanism for antigen presentation

(2015) Stefania Campana et al.   IMMUNOLOGY LETTERS

Top–down analysis of low mass proteins in exosomes shed by murine myeloid-derived suppressor cells

(2015) Lucía Geis-Asteggiante et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Combination of exosomes and circulating microRNAs may serve as a promising tumor marker complementary to alpha-fetoprotein for early-stage hepatocellular carcinoma diagnosis in rats

(2015) Wei-hui Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Effect of hyperthermic CO2-treated dendritic cell-derived exosomes on the human gastric cancer AGS cell line

(2015) JINLIN WANG et al.   Oncology Letters

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

(2015) Xiang-Jun Tang et al.   Oncotarget

Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets

(2015) Graziela Gorete Romagnoli et al.   Frontiers in Immunology

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

(2015) Kirsten Ridder et al.   OncoImmunology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

LncRNA: A link between RNA and cancer

(2014) Guodong Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells

(2014) Andrea Sobo-Vujanovic et al.   CELLULAR IMMUNOLOGY

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Induction of Exosome Release in Primary B Cells Stimulated via CD40 and the IL-4 Receptor

(2014) S. C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma

(2014) Hongwei Wang et al.   Biomed Research International

Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy

(2013) Amanda K. A. Silva et al.   ACS Nano

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Natural CD8+25+ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma

(2013) Yufeng Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Pathogenic role of Epstein–Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma

(2013) Tomokazu Yoshizaki et al.   CANCER LETTERS

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Therapeutics targeting angiogenesis: Genetics and epigenetics, extracellular miRNAs and signaling networks (Review)

(2013) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

Anti-Tumour Effects of Exosomes in Combination with Cyclophosphamide and Polyinosinic–Polycytidylic Acid

(2013) F Guo et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Exosomes from Myeloid-Derived Suppressor Cells Carry Biologically Active Proteins

(2013) Meghan Burke et al.   JOURNAL OF PROTEOME RESEARCH

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy

(2012) F. Kuonen et al.   CLINICAL CANCER RESEARCH

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling

(2012) Jessica Wahlgren et al.   PLoS One

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

(2012) Stephan Munich et al.   OncoImmunology

Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

(2011) R. B. Rountree et al.   CANCER RESEARCH

CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity

(2011) Haifeng Zhang et al.   Cellular & Molecular Immunology

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

(2011) Linda M. Wakim et al.   NATURE

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

(2010) Sophie Viaud et al.   JOURNAL OF IMMUNOTHERAPY

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

(2009) Sophie Viaud et al.   PLoS One

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

B cell activation regulates exosomal HLA production

(2008) Shuji Arita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulated release of B cell-derived exosomes: Do differences in exosome release provide insight into different APC function for B cells and DC?

(2008) Andrew M. Knight   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Exosomes Derived from M. Bovis BCG Infected Macrophages Activate Antigen-Specific CD4+ and CD8+ T Cells In Vitro and In Vivo

(2008) Pramod K. Giri et al.   PLoS One

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

(2008) Venkateswara Rao Simhadri et al.   PLoS One