Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

(2019) María Sancho-Albero et al.   JOURNAL OF NANOBIOTECHNOLOGY

Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes

(2019) Shohei Eda et al.   Nature Catalysis

Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy

(2018) Marcus Hoop et al.   ADVANCED FUNCTIONAL MATERIALS

Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media

(2018) Yiliu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging

(2018) Benjamin J. Stenton et al.   Chemical Science

Bright insights into Palladium-triggered local chemotherapy

(2018) Thomas L Bray et al.   Chemical Science

Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors

(2018) Shilong Zheng et al.   ACS Medicinal Chemistry Letters

ARMMs as a versatile platform for intracellular delivery of macromolecules

(2018) Qiyu Wang et al.   Nature Communications

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

(2018) Yasunori Okamoto et al.   Nature Communications

Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

(2018) Cristian Vidal et al.   Nature Communications

Designed heterogeneous palladium catalysts for reversible light-controlled bioorthogonal catalysis in living cells

(2018) Faming Wang et al.   Nature Communications

Exosomes in cancer: Small transporters with big functions

(2018) Xi Li et al.   CANCER LETTERS

Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium-Functionalized Microdevices

(2018) Catherine Adam et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Future of Bioorthogonal Chemistry

(2018) Neal K. Devaraj   ACS Central Science

The emergent role of exosomes in glioma

(2017) J. Gourlay et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV

(2017) Bence György et al.   MOLECULAR THERAPY

High surface coverage of a self-assembled monolayer by in situ synthesis of palladium nanodeposits

(2017) Lucía Herrer et al.   Nanoscale

An In situ TEM study of the surface oxidation of palladium nanocrystals assisted by electron irradiation

(2017) Dejiong Zhang et al.   Nanoscale

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nano-palladium is a cellular catalyst for in vivo chemistry

(2017) Miles A. Miller et al.   Nature Communications

Copper Catalysis in Living Systems and In Situ Drug Synthesis

(2016) Jessica Clavadetscher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor

(2016) Belén Rubio-Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Shape-controlled continuous synthesis of metal nanostructures

(2016) Victor Sebastian et al.   Nanoscale

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

(2016) Noah I. Hornick et al.   Science Signaling

An enantioselective artificial Suzukiase based on the biotin–streptavidin technology

(2016) Anamitra Chatterjee et al.   Chemical Science

Transition metal catalysis in the mitochondria of living cells

(2016) María Tomás-Gamasa et al.   Nature Communications

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

(2016) Noah I. Hornick et al.   Science Signaling

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Chemical Remodeling of Cell-Surface Sialic Acids through a Palladium-Triggered Bioorthogonal Elimination Reaction

(2015) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exosomal Communication Goes Viral

(2015) David G. Meckes   JOURNAL OF VIROLOGY

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

(2015) J Huan et al.   LEUKEMIA

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy

(2015) Jason T. Weiss et al.   Scientific Reports

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immobilized palladium(II) ion affinity chromatography for recovery of recombinant proteins with peptide tags containing histidine and cysteine

(2014) Pamela Kikot et al.   JOURNAL OF MOLECULAR RECOGNITION

Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors

(2014) Kyung-Ae Yang et al.   Nature Chemistry

Metal-catalyzed uncaging of DNA-binding agents in living cells

(2014) Mateo I. Sánchez et al.   Chemical Science

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

(2014) Jason T. Weiss et al.   Nature Communications

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents

(2013) Ali H. Alhasan et al.   Small

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

A Reaction-Based Fluorescent Probe for Selective Imaging of Carbon Monoxide in Living Cells Using a Palladium-Mediated Carbonylation

(2012) Brian W. Michel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of polystyrene microspheres and functionalization with Pd0 nanoparticles to perform bioorthogonal organometallic chemistry in living cells

(2012) Asier Unciti-Broceta et al.   Nature Protocols

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

(2011) Haishan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells

(2011) Nan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Mediated Cell-Surface Labeling

(2011) Christopher D. Spicer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Check your cultures! A list of cross-contaminated or misidentified cell lines

(2010) Amanda Capes-Davis et al.   INTERNATIONAL JOURNAL OF CANCER

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION