Nanomedicine Strategies to Target Tumor-Associated Macrophages

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer

(2017) Jane Cullis et al.   Cancer Immunology Research

Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells

(2016) Amy M. Wen et al.   BIOCONJUGATE CHEMISTRY

Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment

(2016) Xu Song et al.   BIOMATERIALS

Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases

(2016) Tomonori Tanei et al.   CANCER RESEARCH

Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

(2016) Ryan Ortega et al.   International Journal of Nanomedicine

Coencapsulation of alendronate and doxorubicin in pegylated liposomes: a novel formulation for chemoimmunotherapy of cancer

(2016) Hilary Shmeeda et al.   JOURNAL OF DRUG TARGETING

Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer

(2016) Mengmeng Niu et al.   MOLECULAR PHARMACEUTICS

Differential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant

(2016) Karin A Binnemars-Postma et al.   Nanomedicine

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy

(2016) Jingxing Si et al.   Small

Depletion of Hepatic Macrophages Aggravates Liver Lesions Induced in Rats by Thioacetamide (TAA)

(2016) Hossain M. Golbar et al.   TOXICOLOGIC PATHOLOGY

Targeted delivery of nano-PTX to the brain tumor-associated macrophages

(2016) Lei Zou et al.   Oncotarget

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

(2015) Fan Zhang et al.   BIOMATERIALS

Liposomal simvastatin inhibits tumor growth via targeting tumor-associated macrophages-mediated oxidative stress

(2015) Marius Costel Alupei et al.   CANCER LETTERS

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

355 Targeting the STAT6 pathway to inhibit tumor-associated macrophages-induced tumor growth and metastasis in breast cancer

(2015) K. Binnemars-Postma et al.   EUROPEAN JOURNAL OF CANCER

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Trabectedin for the treatment of breast cancer

(2015) Maurizio D’Incalci et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle

(2015) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles

(2015) C. Perez-Medina et al.   JOURNAL OF NUCLEAR MEDICINE

Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages

(2015) Ryan A. Ortega et al.   Nanoscale

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

Human mononuclear phagocyte system reunited

(2015) Muzlifah Haniffa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Balancing the innate immune system in tumor development

(2015) Catharina Hagerling et al.   TRENDS IN CELL BIOLOGY

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

(2015) Miles A. Miller et al.   Nature Communications

Albumin-bound paclitaxel in solid tumors: clinical development and future directions

(2015) Madappa Kundranda et al.   Drug Design Development and Therapy

Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases

(2015) Sravan Kumar Patel et al.   Theranostics

Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma

(2015) J. L. Jensen et al.   Cancer Immunology Research

M2 polarization enhances silica nanoparticle uptake by macrophages

(2015) Jessica Hoppstädter et al.   Frontiers in Pharmacology

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment

(2015) Anders Olsson et al.   Journal for ImmunoTherapy of Cancer

Non-Viral Nanoparticle Delivers Small Interfering RNA to Macrophages In Vitro and In Vivo

(2015) Mei Zhang et al.   PLoS One

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

(2014) Xiudan Zhan et al.   BIOMATERIALS

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

(2014) P. P. Patwardhan et al.   CLINICAL CANCER RESEARCH

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

(2014) T. S. Kim et al.   CLINICAL CANCER RESEARCH

Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma

(2014) Kirsten Kübler et al.   GYNECOLOGIC ONCOLOGY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Depletion of M2-Like Tumor-Associated Macrophages Delays Cutaneous T-Cell Lymphoma Development In Vivo

(2014) Xuesong Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophages

(2014) Yoshiyuki Hattori et al.   JOURNAL OF LIPOSOME RESEARCH

Emerging applications for ferumoxytol as a contrast agent in MRI

(2014) Mustafa R. Bashir et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Biodistribution and in Vivo Activities of Tumor-Associated Macrophage-Targeting Nanoparticles Incorporated with Doxorubicin

(2014) Mengmeng Niu et al.   MOLECULAR PHARMACEUTICS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Macrophage Depletion by Free Bisphosphonates and Zoledronate-Loaded Red Blood Cells

(2014) Raffaella Sabatino et al.   PLoS One

Quantitative Evaluation of the Reticuloendothelial System Function with Dynamic MRI

(2014) Ting Liu et al.   PLoS One

Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy

(2014) Marjolein Sluijter et al.   PLoS One

Macrophage density and macrophage colony-stimulating factor expression predict the postoperative prognosis in patients with intrahepatic cholangiocarcinoma

(2014) Kosuke Oishi et al.   SURGERY TODAY

SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients

(2014) Neil Desai et al.   Translational Oncology

High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis

(2014) Zhong-Yu Yuan et al.   OncoTargets and Therapy

Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer

(2014) Simon Junankar et al.   Cancer Discovery

Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy

(2014) Warangkana Lohcharoenkal et al.   Biomed Research International

Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models

(2014) L. Shen et al.   Cancer Immunology Research

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells

(2014) Debbie C Strachan et al.   OncoImmunology

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

(2013) Shahneen K. Sandhu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

(2013) Xiaoqiang Tang   CANCER LETTERS

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

(2013) Janesh Pillay et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Tumour-associated macrophages and cancer

(2013) Jenny Cook et al.   CURRENT OPINION IN PHARMACOLOGY

Liposome encapsulation of zoledronic acid results in major changes in tissue distribution and increase in toxicity

(2013) Hilary Shmeeda et al.   JOURNAL OF CONTROLLED RELEASE

Control of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor

(2013) K. Yaddanapudi et al.   JOURNAL OF IMMUNOLOGY

Macrophage-Specific RNA Interference Targeting via “Click”, Mannosylated Polymeric Micelles

(2013) Shann S. Yu et al.   MOLECULAR PHARMACEUTICS

Targeting of Tumor-Associated Macrophages Made Possible by PEG-Sheddable, Mannose-Modified Nanoparticles

(2013) Saijie Zhu et al.   MOLECULAR PHARMACEUTICS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

(2013) N Weizman et al.   ONCOGENE

Hydrazinocurcumin Encapsuled Nanoparticles “Re-Educate” Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression

(2013) Xiwen Zhang et al.   PLoS One

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression

(2013) Claudia A. Dumitru et al.   SEMINARS IN CANCER BIOLOGY

The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins?

(2013) Sven Brandau et al.   SEMINARS IN CANCER BIOLOGY

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

(2012) Carlos E. Prada et al.   ACTA NEUROPATHOLOGICA

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Differential Uptake of Chemically Modified Cowpea Mosaic Virus Nanoparticles in Macrophage Subpopulations Present in Inflammatory and Tumor Microenvironments

(2012) Arpita Agrawal et al.   BIOMACROMOLECULES

PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes

(2012) Landon W. Locke et al.   BIOMATERIALS

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice

(2012) H. Fan et al.   CLINICAL CANCER RESEARCH

Anti-tumour strategies aiming to target tumour-associated macrophages

(2012) Xiaoqiang Tang et al.   IMMUNOLOGY

Effect of molecular size and modification pattern on the internalization of water soluble β-(1→3)-(1→4)-glucan by primary murine macrophages

(2012) Mei Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

(2012) Anders Etzerodt et al.   JOURNAL OF CONTROLLED RELEASE

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles

(2011) H. E. Daldrup-Link et al.   CLINICAL CANCER RESEARCH

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells

(2011) M. Heusinkveld et al.   JOURNAL OF IMMUNOLOGY

Identification and manipulation of tumor associated macrophages in human cancers

(2011) Moniek Heusinkveld et al.   Journal of Translational Medicine

Tumour macrophages as potential targets of bisphosphonates

(2011) Thea L Rogers et al.   Journal of Translational Medicine

Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity

(2011) Debbie Liao et al.   Nanomedicine-Nanotechnology Biology and Medicine

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Carbon Nanotubes Enhance CpG Uptake and Potentiate Antiglioma Immunity

(2010) D. Zhao et al.   CLINICAL CANCER RESEARCH

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages

(2010) Justin P. Edwards et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages

(2010) Wangyang Yu et al.   PHARMACEUTICAL RESEARCH

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells

(2010) Xu-Feng Qi et al.   TOXICOLOGY LETTERS

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β

(2009) Taku Nagai et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Anti-Tumour Effects of Bisphosphonates - What have we Learned from In Vivo Models?

(2009) H. Brown et al.   CURRENT CANCER DRUG TARGETS

The chemokine system in cancer biology and therapy

(2009) Alberto Mantovani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages

(2009) Dorothée Duluc et al.   INTERNATIONAL JOURNAL OF CANCER

Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model

(2009) Michelle VanHandel et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas

(2009) Darya Alizadeh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: In vitro and in vivo evaluation

(2008) Amandeep Kaur et al.   ACTA PHARMACEUTICA

Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status

(2008) Neil P. Desai et al.   ANTI-CANCER DRUGS

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Cancer related inflammation: The macrophage connection

(2008) Antonio Sica et al.   CANCER LETTERS

High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection

(2008) Tong Ding et al.   HUMAN PATHOLOGY

Tumor Versus Tumor-Associated Macrophages: How Hot is the Link?

(2008) C. Guruvayoorappan   INTEGRATIVE CANCER THERAPIES

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE