Exosome-based liquid biopsies in cancer: opportunities and challenges

Multi-analyte liquid biopsies based treatment in advanced refractory cancers.

(2020) Sewanti Limaye et al.   JOURNAL OF CLINICAL ONCOLOGY

Tracking cancer progression: from circulating tumor cells to metastasis

(2020) Francesc Castro-Giner et al.   Genome Medicine

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

(2020) M.C. Liu et al.   ANNALS OF ONCOLOGY

Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

(2020) Farshad Nassiri et al.   NATURE MEDICINE

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

(2020) Barbara Oldrini et al.   Nature Communications

Recent Advances in the Use of Exosomes in Sjögren’s Syndrome

(2020) Yupeng Huang et al.   Frontiers in Immunology

When Less Is More: Specific Capture and Analysis of Tumor Exosomes in Plasma Increases the Sensitivity of Liquid Biopsy for Comprehensive Detection of Multiple Androgen Receptor Phenotypes in Advanced Prostate Cancer Patients

(2020) Chiara Foroni et al.   Biomedicines

Profiling Extracellular Long RNA Transcriptome in Human Plasma and Extracellular Vesicles for Biomarker Discovery

(2020) Rodosthenis S. Rodosthenous et al.   iScience

A Novel Blood-based Panel of Methylated DNA and Protein Markers for Detection of Early-Stage Hepatocellular Carcinoma

(2020) Naga P. Chalasani et al.   Clinical Gastroenterology and Hepatology

Circulating Tumor Cells: Come Together, Right Now, Over Metastasis

(2019) Paulo Rodrigues et al.   Cancer Discovery

Glycans as Biomarkers in Prostate Cancer

(2019) Emma Scott et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non–small Cell Lung Cancer

(2019) Natasha B. Leighl et al.   CLINICAL CANCER RESEARCH

Detection of AR-V7 in Liquid Biopsies of Castrate Resistant Prostate Cancer Patients: A Comparison of AR-V7 Analysis in Circulating Tumor Cells, Circulating Tumor RNA and Exosomes

(2019) Mohammed Nimir et al.   Cells

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

(2019) Aparna R. Parikh et al.   NATURE MEDICINE

Increased Plasmatic Levels of PSA-Expressing Exosomes Distinguish Prostate Cancer Patients from Benign Prostatic Hyperplasia: A Prospective Study

(2019) Mariantonia Logozzi et al.   Cancers

CTCs 2020: Great Expectations or Unreasonable Dreams

(2019) Elisabetta Rossi et al.   Cells

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

(2019) Sophie A. Dusoswa et al.   Journal of Extracellular Vesicles

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

(2019) Celine Everaert et al.   Scientific Reports

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles

(2019) Mikołaj Piotr Zaborowski et al.   Scientific Reports

Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma

(2019) Pamela S. Jones et al.   EBioMedicine

Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry

(2019) Ye Tian et al.   Journal of Extracellular Vesicles

Clonal Hematopoiesis: A new layer in the liquid biopsy story in lung cancer

(2018) Joshua Bauml et al.   CLINICAL CANCER RESEARCH

Exosome-Based Detection ofEGFRT790M in Plasma from Non–Small Cell Lung Cancer Patients

(2018) Elena Castellanos-Rizaldos et al.   CLINICAL CANCER RESEARCH

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells

(2018) Dongsic Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Liquid biopsies to guide therapeutic decisions in rheumatoid arthritis

(2018) Roxana Coras et al.   Translational Research

Molecular Detection and Analysis of Exosomes Using Surface-Enhanced Raman Scattering Gold Nanorods and a Miniaturized Device

(2018) Elyahb Allie Kwizera et al.   Theranostics

Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma

(2018) A K Krug et al.   ANNALS OF ONCOLOGY

A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy

(2018) James McKiernan et al.   EUROPEAN UROLOGY

Urinary Exosomal and cell-free DNA Detects Somatic Mutation and Copy Number Alteration in Urothelial Carcinoma of Bladder

(2018) Dong Hyeon Lee et al.   Scientific Reports

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

(2018) Xia Liu et al.   Cancer Discovery

Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

(2017) Tore Skotland et al.   EUROPEAN JOURNAL OF CANCER

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients

(2017) Marzia Del Re et al.   EUROPEAN UROLOGY

Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers

(2017) Alexis B. Cortot et al.   JNCI-Journal of the National Cancer Institute

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

(2017) Jose C. Contreras-Naranjo et al.   LAB ON A CHIP

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

(2017) Javier M Figueroa et al.   NEURO-ONCOLOGY

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers

(2017) Alexis B. Cortot et al.   JNCI-Journal of the National Cancer Institute

Monitoring of circulating tumor cell trends in a prospective, randomized, placebo-controlled HER2/neu peptide vaccine trial.

(2017) G. T. Clifton et al.   JOURNAL OF CLINICAL ONCOLOGY

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

(2016) Robert A. Stern et al.   JOURNAL OF ALZHEIMERS DISEASE

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

(2016) Zheng Zhao et al.   LAB ON A CHIP

High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients

(2016) Andrew Conley et al.   RNA Biology

Diverse human extracellular RNAs are widely detected in human plasma

(2016) Jane E. Freedman et al.   Nature Communications

Blood Biomarkers for Evaluation of Perinatal Encephalopathy

(2016) Ernest M. Graham et al.   Frontiers in Pharmacology

A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy

(2016) James McKiernan et al.   JAMA Oncology

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection

(2015) Aric L. Gregson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

(2015) Luigino Grasso et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes

(2015) F. A. San Lucas et al.   ANNALS OF ONCOLOGY

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

(2015) Myron G. Best et al.   CANCER CELL

Extracellular vesicle microRNA transfer in cardiovascular disease

(2015) Samarjit Das et al.   CARDIOVASCULAR PATHOLOGY

The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era

(2015) Jaquelyn L. Jahn et al.   INTERNATIONAL JOURNAL OF CANCER

Microfluidic devices to enrich and isolate circulating tumor cells

(2015) J. H. Myung et al.   LAB ON A CHIP

Analysis of Exosome Release as a Cellular Response to MAPK Pathway Inhibition

(2015) K. Agarwal et al.   LANGMUIR

Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method

(2015) Daniel Enderle et al.   PLoS One

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring

(2015) Stephanie M. Schubert et al.   Scientific Reports

KRAS-dependent sorting of miRNA to exosomes

(2015) Diana J Cha et al.   eLife

Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer

(2015) Emmanuel S. Antonarakis et al.   JAMA Oncology

Detecting Exosomes Specifically: A Multiplexed Device Based on Alternating Current Electrohydrodynamic Induced Nanoshearing

(2014) Ramanathan Vaidyanathan et al.   ANALYTICAL CHEMISTRY

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

(2014) François-Clément Bidard et al.   LANCET ONCOLOGY

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

Massively Parallel Sequencing of Human Urinary Exosome/Microvesicle RNA Reveals a Predominance of Non-Coding RNA

(2014) Kevin C. Miranda et al.   PLoS One

Assessment of EGFR Mutations in Circulating Tumor Cell Preparations from NSCLC Patients by Next Generation Sequencing: Toward a Real-Time Liquid Biopsy for Treatment

(2014) Antonio Marchetti et al.   PLoS One

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

(2014) Yusuke Yoshioka et al.   Nature Communications

Single Protein Molecule Detection by Glass Nanopores

(2013) Wenhong Li et al.   ACS Nano

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

5′-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma

(2013) Joseph M. Dhahbi et al.   PHYSIOLOGICAL GENOMICS

Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer

(2012) L. Zhang et al.   CLINICAL CANCER RESEARCH

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury

(2012) Stefania Bruno et al.   PLoS One

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

(2010) Lucy Pigati et al.   PLoS One

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

(2009) J Nilsson et al.   BRITISH JOURNAL OF CANCER

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

(2009) Guilherme Rabinowits et al.   Clinical Lung Cancer

Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data

(2009) Howard I Scher et al.   LANCET ONCOLOGY

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer

(2008) J. S. de Bono et al.   CLINICAL CANCER RESEARCH

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

(2008) Steven J. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY