Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

Serum-Derived Exosomal Proteins as Potential Candidate Biomarkers for Hepatocellular Carcinoma

(2021) Liping Zhao et al.   ACS Omega

Extracellular Nanovesicles: From Intercellular Messengers to Efficient Drug Delivery Systems

(2021) Sachin Kumar Deshmukh et al.   ACS Omega

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

(2021) Isha Gaurav et al.   MOLECULES

Determination of glioma cells’ malignancy and their response to TMZ via detecting exosomal BIGH3 by a TiO2-CTFE-AuNIs plasmonic biosensor

(2021) Chen Xu et al.   CHEMICAL ENGINEERING JOURNAL

The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics

(2021) Abhimanyu Thakur et al.   Protein & Cell

In vivo liquid biopsy for glioblastoma malignancy by the AFM and LSPR based sensing of exosomal CD44 and CD133 in a mouse model

(2021) Abhimanyu Thakur et al.   BIOSENSORS & BIOELECTRONICS

Tetraspanin-6 negatively regulates exosome production

(2020) Rania Ghossoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic and lipidomic analysis of exosomes derived from ovarian cancer cells and ovarian surface epithelial cells

(2020) Lin Cheng et al.   Journal of Ovarian Research

Extracellular vesicle-miRNAs as liquid biopsy biomarkers for disease identification and prognosis in metastatic colorectal cancer patients

(2020) Diego de Miguel Pérez et al.   Scientific Reports

microRNA-141-3p-containing small extracellular vesicles derived from epithelial ovarian cancer cells promote endothelial cell angiogenesis through activating the JAK/STAT3 and NF-κB signaling pathways

(2020) Sajjad Masoumi-Dehghi et al.   Journal of Cell Communication and Signaling

Identification of miRNAs Enriched in Extracellular Vesicles Derived from Serum Samples of Breast Cancer Patients

(2020) Patricia M. M. Ozawa et al.   Biomolecules

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Detection of disease specific parent cells via distinct population of nano-vesicles by machine learning

(2020) Abhimanyu Thakur et al.   CURRENT PHARMACEUTICAL DESIGN

miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1

(2020) Fumihiko Urabe et al.   Science Advances

The Emerging Roles of Exosomes as EMT Regulators in Cancer

(2020) Hyunwoo Kim et al.   Cells

Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases

(2020) Michael Groot et al.   Cells

Extracellular vesicles for tumor targeting delivery based on five features principle

(2020) Tuying Yong et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal transfer of LCP1 promotes osteosarcoma cell tumorigenesis and metastasis by activating the JAK2/STAT3 signaling pathway

(2020) Xuhui Ge et al.   Molecular Therapy-Nucleic Acids

Label-free sensing of exosomal MCT1 and CD147 for tracking metabolic reprogramming and malignant progression in glioma

(2020) A. Thakur et al.   Science Advances

Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains

(2020) Loredana Guglielmi et al.   Cancers

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

(2020) Fatemeh Mehryab et al.   Acta Biomaterialia

microRNA exchange via extracellular vesicles in cancer

(2020) Luyen Tien Vu et al.   CELL PROLIFERATION

Challenges in the development and establishment of exosome-based drug delivery systems

(2020) Jin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Advances in Exosomes‐Based Drug Delivery Systems

(2020) Carmen Gutierrez‐Millan et al.   MACROMOLECULAR BIOSCIENCE

Metabolomic profile of cancer stem cell‐derived exosomes from patients with malignant melanoma

(2020) José Luis Palacios‐Ferrer et al.   Molecular Oncology

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

(2020) Pedro Fuentes et al.   Nature Communications

Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response

(2020) Yaron Vinik et al.   Science Advances

Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease

(2020) Jorge Armando Jiménez-Avalos et al.   MOLECULAR BIOLOGY REPORTS

Exosomal miR‐3180‐3p inhibits proliferation and metastasis of non‐small cell lung cancer by downregulating FOXP4

(2020) Tengfei Chen et al.   Thoracic Cancer

Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages

(2020) Egidia Costanzi et al.   Genes

The miRNA Content of Exosomes Released from the Glioma Microenvironment Can Affect Malignant Progression

(2020) Federica Caponnetto et al.   Biomedicines

Exosomes derived from miR-34a-overexpressing mesenchymal stem cells inhibit in vitro tumor growth: A new approach for drug delivery

(2020) Faezeh Vakhshiteh et al.   LIFE SCIENCES

Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer

(2020) Woo-Cheol Cho et al.   Translational Oncology

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

(2019) Angelica Ortiz et al.   CANCER CELL

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

(2019) María Sancho-Albero et al.   JOURNAL OF NANOBIOTECHNOLOGY

Extracellular vesicles as drug delivery systems methods of production and potential therapeutic applications

(2019) Magdalena Surman et al.   CURRENT PHARMACEUTICAL DESIGN

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Metabolomics identifies serum and exosomes metabolite markers of pancreatic cancer

(2019) Lianyuan Tao et al.   Metabolomics

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

(2019) Shihua Wang et al.   Stem Cell Research & Therapy

Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

(2019) Reza Rahbarghazi et al.   Cell Communication and Signaling

Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs

(2019) Phuong H.L. Tran et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Brainwashed by extracellular vesicles: the role of extracellular vesicles in primary and metastatic brain tumour microenvironment

(2019) Golnaz Morad et al.   Journal of Extracellular Vesicles

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

(2019) Li Min et al.   Journal of Extracellular Vesicles

Exosomal Leucine-Rich-Alpha2-Glycoprotein 1 Derived from Non-Small-Cell Lung Cancer Cells Promotes Angiogenesis via TGF-β Signal Pathway

(2019) Zifan Li et al.   Molecular Therapy-Oncolytics

Engineering dendritic cell vaccines to improve cancer immunotherapy

(2019) Caleb R. Perez et al.   Nature Communications

microRNA-181d-5p-containing exosomes derived from cancer-associated fibroblasts promote epithelial-mesenchymal transition by regulating CDX2/HOXA5 in breast cancer

(2019) Hongbin Wang et al.   Molecular Therapy-Nucleic Acids

Engineering of Exosomes to Target Cancer Metastasis

(2019) Zhenjiang Zhang et al.   Cellular and Molecular Bioengineering

Cancer-Derived Extracellular Vesicle-Associated MicroRNAs in Intercellular Communication: One Cell’s Trash Is Another Cell’s Treasure

(2019) Joseph Mills et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis

(2019) Junyu Cen et al.   Cancers

Exosomal lipids for classifying early and late stage non-small cell lung cancer

(2018) Teresa W.M. Fan et al.   ANALYTICA CHIMICA ACTA

Cholesterol promotes the migration and invasion of renal carcinoma cells by regulating the KLF5/miR-27a/FBXW7 pathway

(2018) Zheng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer

(2018) Zhonghu Li et al.   CANCER LETTERS

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

(2018) Scott W. Messenger et al.   JOURNAL OF CELL BIOLOGY

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

(2018) Yan Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer

(2018) Qihan Fu et al.   ONCOGENE

Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases

(2018) Ying Shan et al.   Cell Death & Disease

Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion

(2018) Joshua S. Brzozowski et al.   Scientific Reports

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker

(2018) Toshie Yoneyama et al.   Journal of Cancer

Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo

(2018) Zhenzhen Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomal double-stranded DNA as a biomarker for the diagnosis and preoperative assessment of pheochromocytoma and paraganglioma

(2018) Liang Wang et al.   Molecular Cancer

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Detection of Glioma-Derived Exosomes with the Biotinylated Antibody-Functionalized Titanium Nitride Plasmonic Biosensor

(2018) Guangyu Qiu et al.   ADVANCED FUNCTIONAL MATERIALS

Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

(2018) Wenjun Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

(2018) Kioomars Saliminejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

(2018) Zaira Boussadia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes

(2018) Mariantonia Logozzi et al.   Cancers

Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

(2017) Tore Skotland et al.   EUROPEAN JOURNAL OF CANCER

Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes

(2017) Jayoung Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression

(2017) Lei Pan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

(2017) Zhen Lu et al.   JOURNAL OF HEPATOLOGY

Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

(2017) Fengming Yang et al.   Molecular Cancer

Role of exosomal proteins in cancer diagnosis

(2017) Weihua Li et al.   Molecular Cancer

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

(2017) Nao Nishida-Aoki et al.   MOLECULAR THERAPY

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

(2017) Javier M Figueroa et al.   NEURO-ONCOLOGY

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

(2017) Jiahui Mao et al.   STEM CELLS

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

(2017) Haiyang Zhang et al.   Nature Communications

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

(2016) Farrukh Aqil et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines

(2016) Tawin Iempridee   EXPERIMENTAL BIOLOGY AND MEDICINE

Exosomal Long Noncoding RNAs are Differentially Expressed in the Cervicovaginal Lavage Samples of Cervical Cancer Patients

(2016) Jin Zhang et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer

(2016) Birgitte Sandfeld-Paulsen et al.   Journal of Thoracic Oncology

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes

(2016) Shinya Sento et al.   PLoS One

Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines

(2016) Aelita Konstantinell et al.   PROTEOMICS

Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts

(2016) S Baroni et al.   Cell Death & Disease

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes

(2016) Stefanie Hiltbrunner et al.   Oncotarget

Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment

(2016) Elham Hosseini-Beheshti et al.   Oncotarget

Lung cancer exosomes as drivers of epithelial mesenchymal transition

(2016) Mohammad A. Rahman et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes

(2016) Claudia Berrondo et al.   PLoS One

Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue

(2015) Gunisha Sagar et al.   GUT

The αvβ6Integrin Is Transferred Intercellularly via Exosomes

(2015) Carmine Fedele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

Rapid and comprehensive ‘shotgun’ lipidome profiling of colorectal cancer cell derived exosomes

(2015) Todd A. Lydic et al.   METHODS

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding

(2015) Shijing Yue et al.   Oncotarget

Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells

(2014) Soichi Sano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes

(2014) Ugur Gezer et al.   CELL BIOLOGY INTERNATIONAL

Regulation of exosome release from mammary epithelial and breast cancer cells – A new regulatory pathway

(2014) Andrew Riches et al.   EUROPEAN JOURNAL OF CANCER

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy

(2014) Kenji Takahashi et al.   MOLECULAR CANCER RESEARCH

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Human B Cell-Derived Lymphoblastoid Cell Lines Constitutively Produce Fas Ligand and Secrete MHCII+FasL+ Killer Exosomes

(2014) Matthew W. Klinker et al.   Frontiers in Immunology

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice

(2013) Lu Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Caught in the act: revealing the metastatic process by live imaging

(2013) M. R. Fein et al.   Disease Models & Mechanisms

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

(2013) Vishnu C. Ramani et al.   FEBS Journal

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes

(2012) Elham Hosseini-Beheshti et al.   MOLECULAR & CELLULAR PROTEOMICS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes

(2012) Deyi Xiao et al.   PLoS One

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis

(2011) Günter Müller et al.   CELLULAR SIGNALLING

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

(2010) S. Viaud et al.   CANCER RESEARCH

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

(2009) Guilherme Rabinowits et al.   Clinical Lung Cancer

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY