Carboranes in drug discovery, chemical biology and molecular imaging

2021 FDA approvals

(2022) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Synthesis and Optoelectronic Properties of Cationic Iridium(III) Complexes with o-Carborane-Based 2-Phenyl Benzothiazole Ligands

(2021) Zi-Jian Yao et al.   INORGANIC CHEMISTRY

Recent developments in the medicinal chemistry of single boron atom-containing compounds

(2021) Shu Song et al.   Acta Pharmaceutica Sinica B

Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells

(2021) Damian Kaniowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

(2021) Stefan Saretz et al.   MOLECULES

Structure–Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists

(2021) David Sedlák et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications

(2020) Xiaolei Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway

(2020) Jing Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Imaging

(2020) Gang Zheng et al.   BIOCONJUGATE CHEMISTRY

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

(2020) Jana Štěpánková et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Too Persistent to Give Up: Aromaticity in Boron Clusters Survives Radical Structural Changes

(2020) Jordi Poater et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells

(2020) Antonio Buzharevski et al.   Scientific Reports

Bimodal Therapeutic Agents against Glioblastoma, one of the most Lethal Cancer

(2020) Hugo Eduardo Cerecetto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

(2020) Marcos Couto et al.   Cells

Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice

(2020) Wakana Sakuma et al.   BEHAVIOURAL BRAIN RESEARCH

Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors

(2020) Shubham Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Approach to Assessing the Innovativeness of New Drugs Finds Accelerating Rate of Innovation

(2020) Todd J. Wills et al.   ACS Medicinal Chemistry Letters

Small Molecule Soluble Epoxide Hydrolase Inhibitors in Multitarget and Combination Therapies for Inflammation and Cancer

(2020) Amarjyoti Das Mahapatra et al.   MOLECULES

Thymidine kinase 1 through the ages: a comprehensive review

(2020) Eliza E. Bitter et al.   Cell and Bioscience

Novel Carborane Compounds Based on Cyclooxygenase‐2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma

(2020) Taofeng Zhang et al.   ChemistrySelect

Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

(2020) Catalina Alamón et al.   Cancers

Novel Isoniazid-Carborane Hybrids Active In Vitro against Mycobacterium tuberculosis

(2020) Daria Różycka et al.   Pharmaceuticals

Binding Affinity of Some Endogenous and Synthetic TSPO Ligands Regarding the rs6971 Polymorphism

(2019) Neydher Berroterán-Infante et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isomeric Carborane Neuromuscular Blocking Agents

(2019) Lalit N. Goswami et al.   ChemMedChem

Nonclassical Applications of closo-Carborane Anions: From Main Group Chemistry and Catalysis to Energy Storage

(2019) S. P. Fisher et al.   CHEMICAL REVIEWS

Aggregation-Induced Electrochemiluminescence of Carboranyl Carbazoles in Aqueous Media

(2019) Xing Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors

(2019) Yasunobu Asawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

(2019) Temidayo O.B. Olusanya et al.   BIOPHYSICAL CHEMISTRY

ER subtype selectivity of m-carborane-containing phenols: C-alkyl groups on the m-carborane cage enhance ERα selectivity

(2019) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carboranylanilinoquinazoline EGFR-inhibitors: toward ‘lead-to-candidate’ stage in the drug-development pipeline

(2019) Marcos Couto et al.   Future Medicinal Chemistry

A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues

(2019) Sirajudeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy

(2019) Sinan Wang et al.   MOLECULAR PHARMACEUTICS

De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor

(2019) Yizhen Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

(2019) Jodie C. Hamrick et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores

(2019) Matthias S. Scholz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficient Nondoped Blue Fluorescent Organic Light-Emitting Diodes (OLEDs) with a High External Quantum Efficiency of 9.4% @ 1000 cd m−2 Based on Phenanthroimidazole−Anthracene Derivative

(2018) Xiangyang Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p -carborane cages

(2018) Asako Kaise et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coordination Chemistry of Carborane Clusters: Metal-Boron Bonds in Carborane, Carboranyl, and Carboryne Complexes

(2018) Bennett J. Eleazer et al.   COMMENTS ON INORGANIC CHEMISTRY

Towards carborane-functionalised structures for the treatment of brain cancer

(2018) Gianpiero Calabrese et al.   DRUG DISCOVERY TODAY

Insight into lipophilicity of deoxyribonucleoside‑boron cluster conjugates

(2018) Aneta Dąbrowska et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Increased Electrical Conductivity in a Mesoporous Metal–Organic Framework Featuring Metallacarboranes Guests

(2018) Chung-Wei Kung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The importance of boron in biological systems

(2018) Irem Uluisik et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Nido -Carboranes: Donors for Thermally Activated Delayed Fluorescence

(2018) Nguyen Van Nghia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative Study of Carborane- and Phenyl-Modified Adenosine Derivatives as Ligands for the A2A and A3 Adenosine Receptors Based on a Rigid in Silico Docking and Radioligand Replacement Assay

(2018) Marian Vincenzi et al.   MOLECULES

Expanding the medicinal chemistry synthetic toolbox

(2018) Jonas Boström et al.   NATURE REVIEWS DRUG DISCOVERY

Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides

(2018) Rajeshwar Narlawar et al.   Chemistry-An Asian Journal

Molecular Modeling of the Interactions between Carborane-Containing Analogs of Indomethacin and Cyclooxygenase-2

(2017) Menyhárt-Botond Sárosi et al.   Journal of Chemical Information and Modeling

Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A “structure-activity relationship” perspective

(2017) Deepak Bhattarai et al.   MEDICINAL RESEARCH REVIEWS

The atopic dermatitis market

(2017) Eleni Pantazi et al.   NATURE REVIEWS DRUG DISCOVERY

Deboronation-Induced Turn-on Phosphorescent Sensing of Fluorides by Iridium(III) Cyclometalates with o-Carborane

(2017) Nguyen Van Nghia et al.   ORGANOMETALLICS

Ambipolar D–A type bifunctional materials with hybridized local and charge-transfer excited state for high performance electroluminescence with EQE of 7.20% and CIEy ∼ 0.06

(2017) Bin Liu et al.   Journal of Materials Chemistry C

Near-infrared fluorophores for biomedical imaging

(2017) Guosong Hong et al.   Nature Biomedical Engineering

Aggregation-Induced Delayed Fluorescence Based on Donor/Acceptor-Tethered Janus Carborane Triads: Unique Photophysical Properties of Nondoped OLEDs

(2016) Ryuhei Furue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice

(2016) Kenta Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Boron clusters in luminescent materials

(2016) Sanjoy Mukherjee et al.   CHEMICAL COMMUNICATIONS

Electrochemistry and Photoluminescence of Icosahedral Carboranes, Boranes, Metallacarboranes, and Their Derivatives

(2016) Rosario Núñez et al.   CHEMICAL REVIEWS

Icosahedral boron clusters: a perfect tool for the enhancement of polymer features

(2016) R. Núñez et al.   CHEMICAL SOCIETY REVIEWS

A Convenient Approach To Synthesize o -Carborane-Functionalized Phosphorescent Iridium(III) Complexes for Endocellular Hypoxia Imaging

(2016) Xiang Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-mycobacterial activity of thymine derivatives bearing boron clusters

(2016) Anna Adamska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments with boron as a platform for novel drug design

(2016) Zbigniew J. Leśnikowski   Expert Opinion on Drug Discovery

Vitamin D receptor 2016: novel ligands and structural insights

(2016) Miguel A. Maestro et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities

(2016) Hang Chen et al.   Expert Review of Anticancer Therapy

Challenges and Opportunities for the Application of Boron Clusters in Drug Design

(2016) Zbigniew J. Leśnikowski   JOURNAL OF MEDICINAL CHEMISTRY

Carborane-based design of a potent vitamin D receptor agonist

(2016) Rocio Otero et al.   Chemical Science

Expanding the chemical space of hydrophobic pharmacophores: the role of hydrophobic substructures in the development of novel transcription modulators

(2016) Shinya Fujii   MedChemComm

Cation-sensitive compartmentalization in metallacarborane containing polymer nanoparticles

(2016) Vladimír Ďorďovič et al.   RSC Advances

Carborane-Containing Hydroxyamidine Scaffolds as Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 (IDO1)

(2015) Christopher J. D. Austin et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands

(2015) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization

(2015) Sihyun Youn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity

(2015) Guangzhe Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Boron-Based Drug Design

(2015) Hyun Seung Ban et al.   CHEMICAL RECORD

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

(2015) Wilma Neumann et al.   ChemMedChem

Straightforward synthesis of radioiodinated Cc-substituted o-carboranes: towards a versatile platform to enable the in vivo assessment of BNCT drug candidates

(2015) K. B. Gona et al.   DALTON TRANSACTIONS

Syntheses and reductions of C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes

(2015) Jan Kahlert et al.   DALTON TRANSACTIONS

Carboranes in the chemist's toolbox

(2015) Russell N. Grimes   DALTON TRANSACTIONS

Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer

(2015) Hitesh K. Agarwal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ortho-Carborane-ModifiedN-Substituted Deoxynojirimycins

(2015) Sascha Hoogendoorn et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

(2015) René Blöcher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions

(2015) Afaf R. Genady et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis and biological evaluation of meta -carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity

(2015) Guangzhe Li et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Biological interaction of living cells with COSAN-based synthetic vesicles

(2015) Màrius Tarrés et al.   Scientific Reports

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

(2014) Shane M. Wilkinson et al.   ACS Chemical Neuroscience

π Aromaticity and Three-Dimensional Aromaticity: Two sides of the Same Coin?

(2014) Jordi Poater et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs

(2014) Shinya Fujii et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs

(2014) Shinya Fujii et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of tetraol derivatives of 1,12-dicarba- closo -dodecaborane as non-secosteroidal vitamin D analogs

(2014) Shinya Fujii et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of human neutrophil activity by adenosine modified with a carborane pharmacophore

(2014) Katarzyna Bednarska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

(2014) Kiran B. Gona et al.   CHEMICAL COMMUNICATIONS

Manipulation of Phosphorescence Efficiency of Cyclometalated Iridium Complexes by Substitutedo-Carboranes

(2014) Young Hoon Lee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carboranes Tuning the Phosphorescence of Iridium Tetrazolate Complexes

(2014) Chao Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carborane-Derived Local Anesthetics are Isomer Dependent

(2014) George R. Kracke et al.   ChemMedChem

The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane

(2014) Christopher J. D. Austin et al.   DALTON TRANSACTIONS

Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA)

(2014) Mohamed E. El-Zaria et al.   DALTON TRANSACTIONS

Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

(2014) Kin Sing Stephen Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

(2014) Ilaria Paterni et al.   STEROIDS

Structure–activity relationship of nonsecosteroidal vitamin D receptor modulators

(2014) Sachiko Yamada et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

(2014) Shingo Tojo et al.   ACS Medicinal Chemistry Letters

Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations

(2014) Pavel Mader et al.   Biomed Research International

Carborane-Based Carbonic Anhydrase Inhibitors

(2013) Jiří Brynda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Variable Photophysical Properties of Phosphorescent Iridium(III) Complexes Triggered bycloso- andnido-Carborane Substitution

(2013) Chao Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced estrogen receptor beta (ERβ) selectivity of fluorinated carborane-containing ER modulators

(2013) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

[18F]Fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates

(2013) Kiran B. Gona et al.   CHEMICAL COMMUNICATIONS

Carborane-Based Metal–Organic Framework with High Methane and Hydrogen Storage Capacities

(2013) Robert D. Kennedy et al.   CHEMISTRY OF MATERIALS

Synthesis, Characterization, and Thermal Behavior of Carboranyl-Styrene Decorated Octasilsesquioxanes: Influence of the Carborane Clusters on Photoluminescence

(2013) Albert Ferrer-Ugalde et al.   CHEMISTRY-A EUROPEAN JOURNAL

2-Carbaborane-3-phenyl-1H-indoles-Synthesis via McMurry Reaction and Cyclooxygenase (COX) Inhibition Activity

(2013) Markus Laube et al.   ChemMedChem

Defining “Innovativeness” in Drug Development: A Systematic Review

(2013) A S Kesselheim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

(2013) Hiroyuki Nakamura et al.   DALTON TRANSACTIONS

The translocator protein (TSPO): A novel target for cancer chemotherapy

(2013) Christopher J.D. Austin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

(2013) Ubaldina Galli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 17α-(carboranylalkyl)estradiols as ligands for estrogen receptors α and β

(2013) David Sedlák et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity

(2013) Hiroyuki Nakamura et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

QM/MM Calculations Reveal the Different Nature of the Interaction of Two Carborane-Based Sulfamide Inhibitors of Human Carbonic Anhydrase II

(2013) Adam Pecina et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Vitamin D Receptor and T Cell Function

(2013) Martin Kongsbak et al.   Frontiers in Immunology

ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors

(2012) Matthias Scholz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure—Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives

(2012) Angsuma Wongmayura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of hypoxia-inducible factor (HIF)-1α inhibitors: Effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia

(2012) Hiroyuki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity

(2012) Hidemitsu Minegishi et al.   ChemMedChem

Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1

(2012) Hitesh K. Agarwal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carboranes Increase the Potency of Small Molecule Inhibitors of Nicotinamide Phosphoribosyltranferase

(2012) Mark W. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Development of androgen receptor ligands by application of ten-vertex para-carborane as a novel hydrophobic core structure

(2012) Shinya Fujii et al.   MedChemComm

Achieving Highly Efficient Fluorescent Blue Organic Light-Emitting Diodes Through Optimizing Molecular Structures and Device Configuration

(2011) Chang-Gua Zhen et al.   ADVANCED FUNCTIONAL MATERIALS

Crystal structure, docking study and structure–activity relationship of carborane-containing androgen receptor antagonist 3-(12-hydroxymethyl-1,12-dicarba-closo-dodecaboran-1-yl)benzonitrile

(2011) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors

(2011) Matthias Scholz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen

(2011) Jason R. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

(2011) Ellen L. Crossley et al.   CHEMICAL COMMUNICATIONS

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds

(2011) Fatiah Issa et al.   CHEMICAL REVIEWS

Aggregation-induced emission

(2011) Yuning Hong et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Characterization of New Fluorescent Styrene-Containing Carborane Derivatives: The Singular Quenching Role of a Phenyl Substituent

(2011) Albert Ferrer-Ugalde et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Silico Carborane Docking to Proteins and Potential Drug Targets

(2011) Matteo Calvaresi et al.   Journal of Chemical Information and Modeling

Highly efficient deep-blue electroluminescence based on the triphenylamine-cored and peripheral blue emitters with segregative HOMO–LUMO characteristics

(2011) Shi Tang et al.   JOURNAL OF MATERIALS CHEMISTRY

Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

(2011) Hong C. Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane

(2011) Shinya Fujii et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

p-Carborane-based androgen antagonists active in LNCaP cells with a mutated androgen receptor

(2011) Shinya Fujii et al.   MedChemComm

Carborane-Conjugated 2-Quinolinecarboxamide Ligands of the Translocator Protein for Boron Neutron Capture Therapy

(2010) Andrea Cappelli et al.   BIOCONJUGATE CHEMISTRY

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

(2010) Kazuki Shimizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology

(2010) Jean-Pierre Droz et al.   BJU INTERNATIONAL

Adenosine and 2′-Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators

(2010) Katarzyna Bednarska et al.   ChemMedChem

Estrogen receptor β selective nonsteroidal estrogens: seeking clinical indications

(2010) Michael L Mohler et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design and Synthesis of Androgen Receptor Full Antagonists Bearing ap-Carborane Cage: Promising Ligands for Anti-Androgen Withdrawal Syndrome

(2010) Tokuhito Goto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical space as a source for new drugs

(2010) Jean-Louis Reymond et al.   MedChemComm

A novel carborane analog, BE360, with a carbon-containing polyhedral boron-cluster is a new selective estrogen receptor modulator for bone

(2009) Michiko Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure

(2009) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carborane Clusters in Computational Drug Design: A Comparative Docking Evaluation Using AutoDock, FlexX, Glide, and Surflex

(2009) Rohit Tiwari et al.   Journal of Chemical Information and Modeling

Synthesis and screening of bifunctional radiolabelled carborane-carbohydrate derivatives

(2009) Andrew E.C. Green et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring

(2008) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure

(2008) Shinya Fujii et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization†

(2008) Cyril Barinka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry

(2008) Alan H. Lipkus et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY