Journal
BIOPHYSICAL CHEMISTRY
Volume 247, Issue -, Pages 25-33Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpc.2019.01.003
Keywords
Boron neutron capture therapy; BNCT; Blood brain barrier; Cancer; Brain tumours; Carboranes; Liposomes
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Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80-100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membradnes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
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