Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

Boron Chemistry for Medical Applications

(2020) Fayaz Ali et al.   MOLECULES

Cardiovascular effects and safety of (non-aspirin) NSAIDs

(2020) Anne-Marie Schjerning et al.   Nature Reviews Cardiology

Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells

(2020) Antonio Buzharevski et al.   Scientific Reports

Non-Classical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open Source Antimalarials

(2020) Edwin Tse et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carboranyl analogues of celecoxib with potent cytostatic ability against human melanoma and colon cancer cell lines

(2019) Antonio Buzharevski et al.   ChemMedChem

Half- and mixed-sandwich metallacarboranes for potential applications in medicine

(2019) Marta Gozzi et al.   PURE AND APPLIED CHEMISTRY

Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells

(2019) Wilasinee Suwanjang et al.   NEUROCHEMICAL RESEARCH

γ-Secretase and its modulators: Twenty years and beyond

(2019) Weiming Xia   NEUROSCIENCE LETTERS

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Tuning Properties for Blood–Brain Barrier Permeation: A Statistics-Based Analysis

(2019) Maria Dichiara et al.   ACS Chemical Neuroscience

Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis

(2017) Ping Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Why Did Tarenflurbil Fail in Alzheimer's Disease?

(2017) Bruno P. Imbimbo   JOURNAL OF ALZHEIMERS DISEASE

Interactions of Boron Clusters and their Derivatives with Serum Albumin

(2017) Tomasz M. Goszczyński et al.   Scientific Reports

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

(2016) Matthew G. Bursavich et al.   JOURNAL OF MEDICINAL CHEMISTRY

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

(2015) Wilma Neumann et al.   ChemMedChem

Carrier Mediated Distribution System (CAMDIS): A new approach for the measurement of octanol/water distribution coefficients

(2015) Bjoern Wagner et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma

(2015) Ersoy Oksuz et al.   JOURNAL OF NEURO-ONCOLOGY

Carbaboranes – more than just phenyl mimetics

(2015) René Frank et al.   PURE AND APPLIED CHEMISTRY

Boron clusters in medicinal chemistry: perspectives and problems

(2015) Detlef Gabel   PURE AND APPLIED CHEMISTRY

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

(2014) Shane M. Wilkinson et al.   ACS Chemical Neuroscience

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT)

(2013) Raymond L. Moss   APPLIED RADIATION AND ISOTOPES

Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease

(2013) Christina J. Crump et al.   BIOCHEMISTRY

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extremely Electron-Rich, Boron-Functionalized, Icosahedral Carborane-Based Phosphinoboranes

(2012) Alexander M. Spokoyny et al.   ORGANOMETALLICS

Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3

(2011) Hiroaki Honjo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

(2011) Ellen L. Crossley et al.   CHEMICAL COMMUNICATIONS

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds

(2011) Fatiah Issa et al.   CHEMICAL REVIEWS

Attenuated Aβ42Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds

(2011) Benedikt Kretner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asborin Inhibits Aldo/Keto Reductase 1A1

(2010) Matthias Scholz et al.   ChemMedChem

Monocarboxylate transport in human corneal epithelium and cell lines

(2009) Kati-Sisko Vellonen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Selective modulation of amyloid-β peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Aβ levels

(2009) Samer O. Abdul-Hay et al.   JOURNAL OF NEUROCHEMISTRY

Permeability of the Blood-Brain Barrier to a Rhenacarborane

(2009) P. M. Hawkins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

(2008) Gordon K Wilcock et al.   LANCET NEUROLOGY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE