Carboranylanilinoquinazoline EGFR-inhibitors: toward ‘lead-to-candidate’ stage in the drug-development pipeline

Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N- 9-Diphenyl-9 H -purin-2-amine scaffold

(2018) Jinxing Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Towards carborane-functionalised structures for the treatment of brain cancer

(2018) Gianpiero Calabrese et al.   DRUG DISCOVERY TODAY

Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers

(2018) Arjun Patra et al.   International Journal of Nanomedicine

Receptor tyrosine kinase-Ras-PI 3 kinase-Akt signaling network in glioblastoma multiforme

(2018) Gulten Tuncel et al.   MEDICAL ONCOLOGY

Glioblastoma Treatments: An Account of Recent Industrial Developments

(2018) Edouard Alphandéry   Frontiers in Pharmacology

Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer

(2017) Verónica A. Trivillin et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Molecular and Genomic Alterations in Glioblastoma Multiforme

(2015) Ines Crespo et al.   AMERICAN JOURNAL OF PATHOLOGY

Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide

(2015) Khaled Messaoudi et al.   DRUG DISCOVERY TODAY

Validity of Ligand Efficiency Metrics

(2014) Christopher W. Murray et al.   ACS Medicinal Chemistry Letters

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

ADMET Evaluation in Drug Discovery. 12. Development of Binary Classification Models for Prediction of hERG Potassium Channel Blockage

(2012) Sichao Wang et al.   MOLECULAR PHARMACEUTICS

Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism

(2011) Yanbin Guan et al.   ARCHIVES OF PHARMACAL RESEARCH

Profiling of a Prescription Drug Library for Potential Renal Drug–Drug Interactions Mediated by the Organic Cation Transporter 2

(2011) Yasuto Kido et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Approach for Predicting P-Glycoprotein (ABCB1) Inhibition Using Molecular Interaction Fields

(2011) Fabio Broccatelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results

(2011) Richard L. Marchese Robinson et al.   Molecular Informatics

Selecting Relevant Descriptors for Classification by Bayesian Estimates: A Comparison with Decision Trees and Support Vector Machines Approaches for Disparate Data Sets

(2011) Miriam Carbon-Mangels et al.   Molecular Informatics

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

(2011) Hai Pham The et al.   Molecular Informatics

ADME Evaluation in Drug Discovery. 10. Predictions of P-Glycoprotein Inhibitors Using Recursive Partitioning and Naive Bayesian Classification Techniques

(2011) Lei Chen et al.   MOLECULAR PHARMACEUTICS

Estimation of ADME Properties with Substructure Pattern Recognition

(2010) Jie Shen et al.   Journal of Chemical Information and Modeling

Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines

(2010) Hiroyuki Nakamura et al.   MedChemComm

Quantitative Structure−Activity Relationship Modeling of Rat Acute Toxicity by Oral Exposure

(2009) Hao Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: Formulation, optimization and in vitro characterization

(2009) Zhang Wei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Benchmark Data Set for in Silico Prediction of Ames Mutagenicity

(2009) Katja Hansen et al.   Journal of Chemical Information and Modeling

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computer-Aided Prediction of Rodent Carcinogenicity by PASS and CISOC-PSCT

(2009) Alexey Lagunin et al.   Quantitative structure-activity relationships & combinatorial science

Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

(2008) Michael D. Prados et al.   JOURNAL OF CLINICAL ONCOLOGY