VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
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Title
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
Authors
Keywords
-
Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 3, Pages -
Publisher
American Society for Microbiology
Online
2019-12-18
DOI
10.1128/aac.01963-19
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Note: Only part of the references are listed.- Infections by OXA-48-like-producing Klebsiella pneumoniae non-co-producing extended spectrum beta-lactamase: can they be treated successfully with cephalosporins?
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- (2019) Vikas Gupta et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
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- (2018) Matt Shirley DRUGS
- The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters
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- Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design
- (2018) Pasquale Linciano et al. ACS Infectious Diseases
- 1405. Efficacy of the Human-Simulated Regimen (HSR) of Cefepime (FEP)/VNRX-5133 Combination Against Serine β-Lactamase-Producing Gram-negative Bacteria in the Neutropenic Murine Thigh Infection Model
- (2018) Kamilia Abdelraouf et al. Open Forum Infectious Diseases
- Mechanisms leading to in vivo ceftolozane/tazobactam resistance development during the treatment of infections caused by MDR Pseudomonas aeruginosa
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- OXA-48-like carbapenemases in the UK: an analysis of isolates and cases from 2007 to 2014
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- The rapid spread of carbapenem-resistant Enterobacteriaceae
- (2016) Robert F. Potter et al. DRUG RESISTANCE UPDATES
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- Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
- (2016) Jürgen Brem et al. Nature Communications
- The global epidemiology of carbapenemase-producing Enterobacteriaceae
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- Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
- (2015) Krystyna M. Kazmierczak et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2015) Karen Bush INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases
- (2015) Scott J. Hecker et al. JOURNAL OF MEDICINAL CHEMISTRY
- A β-lactamase inhibitor revival provides new hope for old antibiotics
- (2015) Ken Garber NATURE REVIEWS DRUG DISCOVERY
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- (2015) H. J. Morrill et al. Open Forum Infectious Diseases
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- Presenting your structures: theCCP4mgmolecular-graphics software
- (2011) S. McNicholas et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form
- (2007) I. Garcia-Saez et al. JOURNAL OF MOLECULAR BIOLOGY
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