Small Molecule Soluble Epoxide Hydrolase Inhibitors in Multitarget and Combination Therapies for Inflammation and Cancer

Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway

(2020) Jing Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics

(2020) Cheng-Peng Sun et al.   BIOORGANIC CHEMISTRY

Natural soluble epoxide hydrolase inhibitors from Inula helenium and their interactions with soluble epoxide hydrolase

(2020) Xin He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase

(2020) Lena Hefke et al.   ACS Medicinal Chemistry Letters

2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis

(2020) Sandra Codony et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors

(2020) Vladimir Burmistrov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarin and Moracin Derivatives from Mulberry Leaves (Morus alba L.) with Soluble Epoxide Hydrolase Inhibitory Activity

(2020) Hong Xu Li et al.   MOLECULES

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

(2019) Allison Gartung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

(2019) Kenji Hashimoto   Frontiers in Pharmacology

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future

(2019) Bomina Park et al.   Frontiers in Pharmacology

Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation

(2019) Min Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

(2019) Raquel Freitas et al.   Nutrients

In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

(2019) Debin Wan et al.   Frontiers in Pharmacology

Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase

(2019) RONG XIA et al.   ANTICANCER RESEARCH

Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor

(2019) Nathani Minaz et al.   BIOMEDICINE & PHARMACOTHERAPY

Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction

(2019) Yann Savina et al.   Diabetes & Vascular Disease Research

Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

(2019) Ryan D. Jones et al.   Frontiers in Pharmacology

1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer’s Signaling in Human Nerve Cells

(2019) Zhibin Liang et al.   ACS Chemical Neuroscience

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

(2019) Simone Schierle et al.   ChemMedChem

Identification of potential soluble epoxide hydrolase (sEH) inhibitors by ligand-based pharmacophore model and biological evaluation

(2019) Sudha Bhagwati et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase

(2019) Kerstin Hiesinger et al.   ACS Medicinal Chemistry Letters

Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores

(2019) Matthias S. Scholz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel amide derivatives of 3-phenylglutaric acid as potent soluble epoxide hydrolase inhibitors

(2019) Elham Rezaee et al.   MOLECULAR DIVERSITY

Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity

(2018) B. Nandha et al.   ARCHIV DER PHARMAZIE

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase

(2018) Sean D. Kodani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adamantyl thioureas as soluble epoxide hydrolase inhibitors

(2018) Vladimir Burmistrov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase

(2018) Alexey Lukin et al.   BIOORGANIC CHEMISTRY

In vitro and in silico investigation of anthocyanin derivatives as soluble epoxide hydrolase inhibitors

(2018) Jang Hoon Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain

(2018) René Blöcher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

(2018) Weicang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

(2018) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators

(2018) Neetika Tripathi et al.   Scientific Reports

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders

(2018) Sydney Zarriello et al.   PROGRESS IN NEUROBIOLOGY

In silico investigation of cycloartane triterpene derivatives from Cimicifuga dahurica (Turcz.) Maxim. roots for the development of potent soluble epoxide hydrolase inhibitors

(2017) Nguyen Phuong Thao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

(2017) Hernan Roca et al.   JOURNAL OF CLINICAL INVESTIGATION

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

(2017) Jurema Schmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

(2017) Xiang Dong Su et al.   MEDICINAL CHEMISTRY RESEARCH

Soluble epoxide hydrolase inhibitory activity of phenolic glycosides from Polygala tenuifolia and in silico approach

(2017) Le Ba Vinh et al.   MEDICINAL CHEMISTRY RESEARCH

COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin

(2017) Fuli Wang et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

(2017) Jiong Hu et al.   NATURE

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

(2017) Karen M. Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways

(2017) Xin-wei Dong et al.   TOXICOLOGY

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis

(2017) Lan Dai et al.   Oncotarget

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

(2017) Veronika Temml et al.   Scientific Reports

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

(2017) Ulrike Garscha et al.   Scientific Reports

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

(2016) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies

(2016) Gwo Yaw Ho et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening

(2016) Birgit Waltenberger et al.   Journal of Chemical Information and Modeling

Soluble epoxide hydrolase inhibitory components from Rheum undulatum and in silico approach

(2016) Ah Reum Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use

(2016) Jun-Yan Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

(2016) Karin Meirer et al.   MOLECULES

Novel soluble epoxide hydrolase inhibitors with a dihydropyrimidinone scaffold: design, synthesis and biological evaluation

(2016) Elham Rezaee et al.   MedChemComm

Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease

(2015) Ga Young Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

(2015) Yong Zhou et al.   CELL AND TISSUE RESEARCH

Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa

(2015) Jang Hoon Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Soluble Epoxide Hydrolase Inhibitory Activity of Selaginellin Derivatives from Selaginella tamariscina

(2015) Jang Kim et al.   MOLECULES

Potent Natural Soluble Epoxide Hydrolase Inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and In Vivo

(2015) Seiya Kitamura et al.   PLoS One

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

(2015) Alexander Litovchick et al.   Scientific Reports

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography

(2014) Yasushi Amano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

(2014) Xiaolong Wei et al.   BMC CANCER

Implication of Transient Receptor Potential Vanilloid Type 1 in 14,15-Epoxyeicosatrienoic Acid-induced Angiogenesis

(2014) Kuo-Hui Su et al.   International Journal of Biological Sciences

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

(2014) Jamie C. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

(2014) Kin Sing Stephen Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

(2014) John R. Falck et al.   JOURNAL OF MEDICINAL CHEMISTRY

COX-2 as a target for cancer chemotherapy

(2014) Nilanjan Ghosh et al.   Pharmacological Reports

Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis

(2014) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

(2013) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo

(2013) Li Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides

(2013) Christophe Morisseau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors

(2013) Sung Hee Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties

(2013) Estel.la Buscató et al.   ChemMedChem

Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid

(2013) Tadafumi Kubota et al.   FASEB JOURNAL

Discovery of soluble epoxide hydrolase inhibitors from natural products

(2013) Gwan Ho Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity

(2013) Jonathan W. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase

(2013) Karin Meirer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

(2013) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps

(2013) Janosch Achenbach et al.   ACS Medicinal Chemistry Letters

DESIGN, ADMET AND DOCKING STUDIES ON SOME NOVEL CHALCONE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORS

(2013) KUPPUSAMY ASOKKUMAR et al.   JOURNAL OF THE CHILEAN CHEMICAL SOCIETY

Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors

(2012) Stevan Pecic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys

(2012) A Ulu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress

(2012) Sri N. Batchu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis

(2012) S. I. Park et al.   CANCER RESEARCH

t-AUCB, an improved sEH inhibitor, suppresses human glioblastoma cell growth by activating NF-κB-p65

(2012) Junyang Li et al.   JOURNAL OF NEURO-ONCOLOGY

Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency

(2012) Wanying Zhang et al.   MOLECULAR CARCINOGENESIS

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology

(2012) John D. Imig   PHYSIOLOGICAL REVIEWS

Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase

(2012) Shao-Xu Huang et al.   MedChemComm

Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

(2012) Daniel Moser et al.   ACS Medicinal Chemistry Letters

Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

(2011) Stevan Pecic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EET signaling in cancer

(2011) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

(2011) Rafael B. Blasco et al.   CANCER CELL

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects

(2011) Dawn Chen et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of Potent Inhibitors of Soluble Epoxide Hydrolase by Combinatorial Library Design and Structure-Based Virtual Screening

(2011) Li Xing et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships of Cycloalkylamide Derivatives as Inhibitors of the Soluble Epoxide Hydrolase

(2011) In-Hae Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

(2011) Sung Hee Hwang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

(2011) Hong C. Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP

(2011) B. Inceoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception

(2011) Karen Wagner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Substituted pyrazoles as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain

(2010) Ho Yin Lo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs

(2010) Hsing-Ju Tsai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Epoxygenated Fatty Acids and Soluble Epoxide Hydrolase Inhibition: Novel Mediators of Pain Reduction

(2010) Karen Wagner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

(2010) Tristan E. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

(2010) Daisuke Tanaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

17,18-Epoxyeicosatetraenoic Acid Targets PPARγ and p38 Mitogen–Activated Protein Kinase to Mediate Its Anti-inflammatory Effects in the Lung

(2009) Caroline Morin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia

(2009) Le-Ning Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

(2009) Jun-Yan Liu et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

(2009) Hong C. Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors

(2009) Hong C. Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unsymmetrical non-adamantyl N,N′-diaryl urea and amide inhibitors of soluble expoxide hydrolase

(2009) Sampath-Kumar Anandan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase

(2009) Anne B. Eldrup et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement

(2009) Hong C. Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Optimization of Arylamides as Inhibitors of Soluble Epoxide Hydrolase

(2009) Anne B. Eldrup et al.   JOURNAL OF MEDICINAL CHEMISTRY

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates Containing Epoxide Bioisosteres: Influence upon Vascular Relaxation and Soluble Epoxide Hydrolase Inhibition

(2009) J. R. Falck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

(2009) J.-Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

(2008) Yuli Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids

(2008) G. Yan et al.   CARDIOVASCULAR RESEARCH

Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension

(2008) Jing Li   Frontiers in Bioscience-Landmark

Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

(2008) B. Inceoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA