Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

Too Persistent to Give Up: Aromaticity in Boron Clusters Survives Radical Structural Changes

(2020) Jordi Poater et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abnormal mitosis in reactive astrocytes

(2020) Alexander Sosunov et al.   Acta Neuropathologica Communications

Bimodal Therapeutic Agents against Glioblastoma, one of the most Lethal Cancer

(2020) Hugo Eduardo Cerecetto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

(2020) Marcos Couto et al.   Cells

Cannabidiol Enhances the Passage of Lipid Nanocapsules across the Blood–Brain Barrier Both in Vitro and in Vivo

(2019) Juan Aparicio-Blanco et al.   MOLECULAR PHARMACEUTICS

The role of microglia in viral encephalitis: a review

(2019) Zhuangzhuang Chen et al.   Journal of Neuroinflammation

Neutron spectrometry of the 9Be(d (1.45 MeV), n)10B reaction for accelerator-based BNCT

(2019) M.E. Capoulat et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

(2019) Vadim Le Joncour et al.   Jove-Journal of Visualized Experiments

Carboranylanilinoquinazoline EGFR-inhibitors: toward ‘lead-to-candidate’ stage in the drug-development pipeline

(2019) Marcos Couto et al.   Future Medicinal Chemistry

Crizotinib and erlotinib inhibits growth of c-Met + /EGFRvIII + primary human glioblastoma xenografts

(2018) C. Rory Goodwin et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Astrocytes, the rising stars of the glioblastoma microenvironment

(2018) Mayra Brandao et al.   GLIA

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

(2017) Emily-Marie Latuske et al.   Oncotarget

The Loss of a Sugar Chain at C(3) Position Enhances Stemucronatoside K-Induced Apoptosis, Cell Cycle Arrest, and Hedgehog Pathway Inhibition in HT-29 Cells

(2016) Xia Zhou et al.   CHEMISTRY & BIODIVERSITY

Hückel's Rule of Aromaticity Categorizes Aromatic closo Boron Hydride Clusters

(2016) Jordi Poater et al.   CHEMISTRY-A EUROPEAN JOURNAL

B–H···π Interaction: A New Type of Nonclassical Hydrogen Bonding

(2016) Xiaolei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Global Burden of Cancer 2013

(2015) Christina Fitzmaurice et al.   JAMA Oncology

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

(2015) Chuan Bian Lim et al.   Oncotarget

Synthesis and in Vitro Evaluation of BBB Permeability, Tumor Cell Uptake, and Cytotoxicity of a Series of Carboranylporphyrin Conjugates

(2014) N. V. S. Dinesh K. Bhupathiraju et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sunitinib administered prior to radiotherapy in patients with non-resectable glioblastoma: results of a Phase II study

(2014) Carmen Balaña et al.   Targeted Oncology

Matching chelators to radiometals for radiopharmaceuticals

(2013) Eric W. Price et al.   CHEMICAL SOCIETY REVIEWS

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma

(2013) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

State of the art survey on MRI brain tumor segmentation

(2013) Nelly Gordillo et al.   MAGNETIC RESONANCE IMAGING

A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07)

(2013) Markus Hutterer et al.   NEURO-ONCOLOGY

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

ADMET Evaluation in Drug Discovery. 12. Development of Binary Classification Models for Prediction of hERG Potassium Channel Blockage

(2012) Sichao Wang et al.   MOLECULAR PHARMACEUTICS

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

(2012) Rolf F Barth et al.   Radiation Oncology

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds

(2011) Fatiah Issa et al.   CHEMICAL REVIEWS

Role of GLI2 in the growth of human osteosarcoma

(2011) Hiroko Nagao et al.   JOURNAL OF PATHOLOGY

Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results

(2011) Richard L. Marchese Robinson et al.   Molecular Informatics

Selecting Relevant Descriptors for Classification by Bayesian Estimates: A Comparison with Decision Trees and Support Vector Machines Approaches for Disparate Data Sets

(2011) Miriam Carbon-Mangels et al.   Molecular Informatics

Estimation of ADME Properties with Substructure Pattern Recognition

(2010) Jie Shen et al.   Journal of Chemical Information and Modeling

CoCl2Induces Apoptosis via the 18 kDa Translocator Protein in U118MG Human Glioblastoma Cells

(2009) Sivan Zeno et al.   BIOCHEMISTRY

Sunitinib

(2009) Georgios S. Papaetis et al.   BIODRUGS

Closing the gap between the in-vivo and in-vitro blood–brain barrier tightness

(2009) Katayun Cohen-Kashi Malina et al.   BRAIN RESEARCH

Quantitative Structure−Activity Relationship Modeling of Rat Acute Toxicity by Oral Exposure

(2009) Hao Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

An in vitro study, evaluating the effect of sunitinib and/or lapatinib on two glioma cell lines

(2009) Efstathia Giannopoulou et al.   INVESTIGATIONAL NEW DRUGS

Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines

(2009) Ke Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Computer-Aided Prediction of Rodent Carcinogenicity by PASS and CISOC-PSCT

(2009) Alexey Lagunin et al.   Quantitative structure-activity relationships & combinatorial science

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Mechanisms of Myocyte Cytotoxicity Induced by the Multiple Receptor Tyrosine Kinase Inhibitor Sunitinib

(2008) B. B. Hasinoff et al.   MOLECULAR PHARMACOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY