Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 48, Pages 17282-17290Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603340
Keywords
carboranes; imaging agents; iridium; phosphorescence; structure-property relationships
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Funding
- National Natural Science Foundation of China [21271102, 21472086, 21531004]
- Major State Basic Research Development Program of China [2013CB922100]
- high-performance computational center of Nanjing University
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The structure-property relationship of carborane-modified iridium(III) complexes was investigated. Firstly, an efficient approach for the synthesis of o-carborane-containing pyridine ligands a-f in high yields was developed by utilizing stable and cheap B10H10(Et4N)(2) as the starting material. By using these ligands, iridium(III) complexes I-VII were efficiently prepared. In combination with DFT calculations, the photophysical and electrochemical properties of these complexes were studied. The hydrophilic nido-o-carborane-based iridium(III) complex VII showed the highest phosphorescence efficiency (abs. phi P =0.48) among known water-soluble homoleptic cyclometalated iridium(III) complexes and long emission lifetime (=1.24s) in aqueous solution. Both of them are sensitive to O-2, and thus endocellular hypoxia imaging of complex VII was realized by time-resolved luminescence imaging (TRLI). This is the first example of applying TRLI in endocellular oxygen detection with a water-soluble nido-carborane functionalized iridium(III) complex.
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