The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance

Targeting Mitochondrial COX-2 Enhances Chemosensitivity via Drp1-Dependent Remodeling of Mitochondrial Dynamics in Hepatocellular Carcinoma

(2022) Lin Che et al.   Cancers

SIRT3-Mediated SOD2 and PGC-1α Contribute to Chemoresistance in Colorectal Cancer Cells

(2021) Masakatsu Paku et al.   ANNALS OF SURGICAL ONCOLOGY

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis

(2021) Yang Cao et al.   Cancer Medicine

miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis

(2021) Juan Zhang et al.   Aging-US

miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma

(2021) Chenglong Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition

(2021) Liguo Liu et al.   CANCER LETTERS

SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin

(2021) Hao Chen et al.   Genes & Genomics

Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis

(2021) Xiangyun Chen et al.   JOURNAL OF PINEAL RESEARCH

Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer

(2021) Jin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

LncRNA FENDRR Inhibits Gastric Cancer Cell Proliferation and Invasion via the miR-421/SIRT3/Notch-1 Axis

(2021) Jia Ma et al.   Cancer Management and Research

SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells

(2021) Nunzia D’Onofrio et al.   Cancers

Mitochondrial Management of Reactive Oxygen Species

(2021) Gaetana Napolitano et al.   Antioxidants

Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet

(2020) Mohamed A. Ahmed et al.   Frontiers in Oncology

SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis

(2020) Rui Guo et al.   GENE

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

(2020) Haozhen Han et al.   MOLECULES

ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation

(2020) Mei-Chun Chen et al.   Cells

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

(2020) Xingyou Wan et al.   Cell Death & Disease

Advances in characterization of SIRT3 deacetylation targets in mitochondrial function

(2020) Shuhan Wang et al.   BIOCHIMIE

Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma

(2020) Shouyue Zhang et al.   Acta Pharmaceutica Sinica B

A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3

(2020) Babu Gajendran et al.   Communications Biology

MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3

(2019) Shanshan Huang et al.   PATHOLOGY RESEARCH AND PRACTICE

Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer

(2019) Xue Wang et al.   Thoracic Cancer

Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity

(2019) Qianli Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

(2019) Lei Xu et al.   Cancer Medicine

SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

(2019) Jiao Ma et al.   BRITISH JOURNAL OF HAEMATOLOGY

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

(2019) Meng Li et al.   CANCER CELL

4′‐Bromo‐resveratrol, a dual Sirtuin‐1 and Sirtuin‐3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming

(2019) Jasmine George et al.   MOLECULAR CARCINOGENESIS

miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-β/SMAD signaling pathway

(2019) Jinqian Zhang et al.   Scientific Reports

Mitochondria in Health and Disease

(2019) Sarah J. Annesley et al.   Cells

MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma

(2019) Yu-Yu Kao et al.   CANCER LETTERS

ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation

(2019) Lin Hou et al.   LIFE SCIENCES

SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase

(2019) Li Xiu Xu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

(2019) Yeon Soo Kim et al.   ONCOGENE

A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis

(2019) Praveen Kumar Neeli et al.   ONCOGENE

Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation

(2018) Penghao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The contributions of cancer cell metabolism to metastasis

(2018) Gloria Pascual et al.   Disease Models & Mechanisms

Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D

(2018) Zhendong Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/β-catenin pathway

(2018) Rong Li et al.   EXPERIMENTAL CELL RESEARCH

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

(2018) Margalida Torrens-Mas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway

(2018) Shaojia Wang et al.   ONCOGENE

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3

(2018) Jaewon J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis

(2018) Huan Liu et al.   JOURNAL OF PROTEOME RESEARCH

Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation

(2018) Liang-Jun Wang et al.   BIOCHEMICAL PHARMACOLOGY

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

(2017) T C Kenny et al.   ONCOGENE

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

(2017) T Ren et al.   ONCOGENE

Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells

(2017) Takashi Okumura et al.   Oncotarget

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

(2017) Yin Li et al.   Frontiers in Pharmacology

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

(2017) Lian-Xiang Luo et al.   Frontiers in Pharmacology

Down-regulation of SIRT3 promotes ovarian carcinoma metastasis

(2016) Xue-cai Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine

(2016) Di Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sirtuin 3: A Janus face in cancer (Review)

(2016) Yanlu Xiong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production

(2016) Margalida Torrens-Mas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

(2016) Na-Na Tao et al.   Oncotarget

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

(2016) Aimin Qiao et al.   Oncotarget

Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

(2016) Aritro Nath et al.   Scientific Reports

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

(2015) H. Yang et al.   EMBO JOURNAL

Mitochondrial sirtuins: Emerging roles in metabolic regulations, energy homeostasis and diseases

(2015) Priyanka Parihar et al.   EXPERIMENTAL GERONTOLOGY

Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

(2015) Kai Zhao et al.   Journal of Hematology & Oncology

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

(2015) Yang Cui et al.   PLoS One

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation

(2014) Lijun Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors

(2014) Sumit S. Mahajan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

(2014) Wantong Yao et al.   Molecular Cancer

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

(2014) S M Jeong et al.   ONCOGENE

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

MicroRNAs in Cancer

(2013) Gianpiero Di Leva et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

(2013) Athanassios Vassilopoulos et al.   ANTIOXIDANTS & REDOX SIGNALING

Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer

(2013) Bing Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Mitochondria in ageing: there is metabolism beyond the ROS

(2013) Michael Breitenbach et al.   FEMS YEAST RESEARCH

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

(2012) Santina Bruzzone et al.   CURRENT PHARMACEUTICAL DESIGN

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Sirtuins, Metabolism, and Cancer

(2012) Barbara Martinez-Pastor et al.   Frontiers in Pharmacology

Radical Decisions in Cancer: Redox Control of Cell Growth and Death

(2012) Rosa M. Sainz et al.   Cancers

SIRT3 and cancer: Tumor promoter or suppressor?

(2011) Turki Y. Alhazzazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

(2010) Lei Jin et al.   PROTEIN SCIENCE

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS