SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

Blockade of JAK2/STAT3 intensifies the anti-tumor activity of arsenic trioxide in acute myeloid leukemia cells: Novel synergistic mechanism via the mediation of reactive oxygen species

(2018) Yashar Mesbahi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

(2018) Courtney D. DiNardo et al.   BLOOD

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Therapeutic targeting of leukemic stem cells in acute myeloid leukemia – the biological background for possible strategies

(2017) Øystein Bruserud et al.   Expert Opinion on Drug Discovery

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells

(2017) Aaron D. Schimmer   Cancer Discovery

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia

(2016) Nana Zhe et al.   CANCER BIOLOGY & THERAPY

Post-translational modifications in mitochondria: protein signaling in the powerhouse

(2016) Amanda R. Stram et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine

(2016) Himalee S. Sabnis et al.   LEUKEMIA RESEARCH

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

(2016) Hong-Sheng Zhou et al.   Cancer Biology & Medicine

An update of current treatments for adult acute myeloid leukemia

(2015) H. Dombret et al.   BLOOD

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

(2015) M. C. Caino et al.   CLINICAL CANCER RESEARCH

CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance

(2015) R. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Post-translational modification of mitochondria as a novel mode of regulation

(2014) Annette Hofer et al.   EXPERIMENTAL GERONTOLOGY

Combination of Oxidative Stress and FOXM1 Inhibitors Induces Apoptosis in Cancer Cells and Inhibits Xenograft Tumor Growth

(2013) Marianna Halasi et al.   AMERICAN JOURNAL OF PATHOLOGY

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Reactive oxygen species and endothelial function in diabetes

(2010) Zahra Fatehi-Hassanabad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Energy metabolism of leukemia cells: glycolysisversusoxidative phosphorylation

(2010) Kazuto Suganuma et al.   LEUKEMIA & LYMPHOMA

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

(2009) Claudia Figueroa-Romero et al.   FASEB JOURNAL