SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis

(2018) Hong-Wei Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells

(2018) Ryo Yonashiro et al.   CANCER RESEARCH

Inhibition of glycolytic metabolism in glioblastoma cells by Pt3glc combinated with PI3K inhibitor via SIRT3-mediated mitochondrial and PI3K/Akt-MAPK pathway

(2018) Gang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer

(2018) Steven C. Eastlack et al.   Molecular Cancer

Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway

(2018) Shaojia Wang et al.   ONCOGENE

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3

(2018) Jaewon J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase

(2018) Tereza Golias et al.   INTERNATIONAL JOURNAL OF CANCER

SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis

(2018) Huan Liu et al.   JOURNAL OF PROTEOME RESEARCH

The role of YAP/TAZ activity in cancer metabolic reprogramming

(2018) Xiaodong Zhang et al.   Molecular Cancer

CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis

(2018) Weilin Li et al.   ONCOGENE

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

(2018) Sungmi Park et al.   Diabetes & Metabolism Journal

Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect

(2017) Wen Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibition of HIF1α and PDK Induces Cell Death of Glioblastoma Multiforme

(2017) Jiwon Esther Han et al.   Experimental Neurobiology

The A 2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

(2016) Christina Mølck et al.   CANCER LETTERS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching

(2015) Kristin E. Dittenhafer-Reed et al.   Cell Metabolism

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism

(2015) H. Shen et al.   MOLECULAR CANCER THERAPEUTICS

Clonorchis sinensis excretory/secretory products promote the secretion of TNF-alpha in the mouse intrahepatic biliary epithelial cells via Toll-like receptor 4

(2015) Chao Yan et al.   Parasites & Vectors

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

(2015) Yang Cui et al.   PLoS One

Regulation of the Warburg Effect in Early-Passage Breast Cancer Cells

(2015) Ian F. Robey et al.   NEOPLASIA

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

(2014) John Bridgewater et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

(2014) Wantong Yao et al.   Molecular Cancer

Hypoxia Regulates Alternative Splicing of HIF and non-HIF Target Genes

(2014) J. A. Sena et al.   MOLECULAR CANCER RESEARCH

Up-regulation of glycolytic metabolism is required for HIF1 -driven bone formation

(2014) J. N. Regan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1 

(2013) J.-H. Lai et al.   NEURO-ONCOLOGY

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update

(2012) Shahid A Khan et al.   GUT

HIF1α Protein Stability Is Increased by Acetylation at Lysine 709

(2012) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

Review article: surgical, neo-adjuvant and adjuvant management strategies in biliary tract cancer

(2011) J. R. A. Skipworth et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells

(2009) Masaki Nagaya et al.   JOURNAL OF ENDOCRINOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

(2008) S M Wigfield et al.   BRITISH JOURNAL OF CANCER