Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

Honokiol, a potential therapeutic agent, induces cell cycle arrest and program cell death in vitro and in vivo in human thyroid cancer cells

(2017) Chieh-Hsiang Lu et al.   PHARMACOLOGICAL RESEARCH

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration

(2016) Poh-Shiow Yeh et al.   CANCER LETTERS

Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway

(2016) Jing Pan et al.   Cancer Prevention Research

Honokiol targets mitochondria to halt cancer progression and metastasis

(2016) Jing Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway

(2016) Chien-Ju Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

(2016) Yu-Chen Cheng et al.   Oncotarget

Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1

(2016) Jingyuan Li et al.   Oncotarget

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

(2016) Jung Min Song et al.   Oncotarget

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

p27Kip1and p21Cip1collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes

(2015) Serena Orlando et al.   NUCLEIC ACIDS RESEARCH

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis

(2015) Qing Zhang et al.   Oncotarget

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

(2015) Dimiter B. Avtanski et al.   Oncotarget

Traditional Chinese medicine and cancer: History, present situation, and development

(2015) Jie Liu et al.   Thoracic Cancer

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer

(2014) Benjamin J. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRASG12D-driven lung tumors

(2013) Jessie Yanxiang Guo et al.   Autophagy

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance

(2013) Esther Castellano et al.   CANCER CELL

Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities

(2013) Ankit Kumar et al.   Future Medicinal Chemistry

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2

(2013) HONGQI LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sirt3 is a tumor suppressor in lung adenocarcinoma cells

(2013) KUI XIAO et al.   ONCOLOGY REPORTS

The transcriptional landscape and mutational profile of lung adenocarcinoma

(2012) J.-S. Seo et al.   GENOME RESEARCH

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells

(2011) Sumit Arora et al.   PLoS One

Honokiol Inhibits Epidermal Growth Factor Receptor Signaling and Enhances the Antitumor Effects of Epidermal Growth Factor Receptor Inhibitors

(2010) R. J. Leeman-Neill et al.   CLINICAL CANCER RESEARCH

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

(2010) W. Hsiao et al.   PLANTA MEDICA

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE