Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+and SRT1720: binding details and inhibition mechanism

(2013) Giang Thi Tuyet Nguyen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer

(2013) Yue Zhao et al.   Annals of Diagnostic Pathology

Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer

(2013) Bing Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells

(2013) Li Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Identification of novel SIRT3 inhibitor scaffolds by virtual screening

(2013) Heikki S. Salo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Maintaining good hearing: Calorie restriction, Sirt3, and glutathione

(2013) Chul Han et al.   EXPERIMENTAL GERONTOLOGY

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered expression of SIRT gene family in head and neck squamous cell carcinoma

(2013) Chi-Chih Lai et al.   TUMOR BIOLOGY

Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer

(2013) B Liu et al.   Cell Death & Disease

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

(2013) Y Cheng et al.   Cell Death & Disease

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis

(2012) Pachiyappan Kamarajan et al.   CANCER

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

(2012) Santina Bruzzone et al.   CURRENT PHARMACEUTICAL DESIGN

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

(2012) Marcin Buler et al.   PLoS One

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

(2011) Paul T. Schumacker   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

(2011) Tetsuro Koyama et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis

(2011) Seong-Hoon Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

(2011) Albert Giralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SirT3 Divining Rod Points to Oxidative Stress

(2011) Eric L. Bell et al.   MOLECULAR CELL

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase

(2010) SiDe Li et al.   PLoS One

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Lifelong Calorie Restriction Alleviates Age-Related Oxidative Damage in Peripheral Nerves

(2010) Katherine Opalach et al.   REJUVENATION RESEARCH

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

(2009) Yongjie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Where in the cell is SIRT3? – functional localization of an NAD+-dependent protein deacetylase

(2008) William C. Hallows et al.   BIOCHEMICAL JOURNAL

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes

(2008) Srujana Rayalam et al.   PHYTOTHERAPY RESEARCH

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA