SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer

(2013) Yue Zhao et al.   Annals of Diagnostic Pathology

Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells

(2013) Li Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells

(2012) N. Duru et al.   CLINICAL CANCER RESEARCH

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial sirtuins: regulators of protein acylation and metabolism

(2012) Wenjuan He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Acetate metabolism and aging: An emerging connection

(2010) Tadahiro Shimazu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines

(2010) Rajaa Hussien et al.   PHYSIOLOGICAL GENOMICS

p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase

(2010) SiDe Li et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Down-regulation of miR-141 in gastric cancer and its involvement in cell growth

(2009) Ying Du et al.   JOURNAL OF GASTROENTEROLOGY

Where in the cell is SIRT3? – functional localization of an NAD+-dependent protein deacetylase

(2008) William C. Hallows et al.   BIOCHEMICAL JOURNAL

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction

(2008) Xuesen Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

miR-21 plays a pivotal role in gastric cancer pathogenesis and progression

(2008) Zhiyu Zhang et al.   LABORATORY INVESTIGATION

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA