Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer

(2016) Francesca Rappa et al.   CELL STRESS & CHAPERONES

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Mitochondrial UPR: A Double-Edged Sword

(2016) Ye Tian et al.   TRENDS IN CELL BIOLOGY

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

(2016) Jae Ho Seo et al.   PLOS BIOLOGY

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma

(2015) Yang Yuan et al.   BMC CANCER

Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis

(2015) L. V. Yuzefovych et al.   CANCER RESEARCH

Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential

(2015) K. P. Feeley et al.   CANCER RESEARCH

Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy

(2015) Emilie Obre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Enhanced tumorigenicity by mitochondrial DNA mild mutations

(2015) Alberto Cruz-Bermúdez et al.   Oncotarget

Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates

(2014) Sarah McMahon et al.   CARCINOGENESIS

OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration

(2014) J. B. Nunes et al.   HUMAN MOLECULAR GENETICS

SOD2 to SOD1 Switch in Breast Cancer

(2014) Luena Papa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype

(2013) Gaku Takibuchi et al.   MITOCHONDRION

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis

(2012) Jana Jandova et al.   EXPERIMENTAL CELL RESEARCH

Regulation of metastasis; mitochondrial DNA mutations have appeared on stage

(2012) Kaori Ishikawa et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

(2011) Hirotake Imanishi et al.   PLoS One

Oncocytic carcinoma of the breast: frequency, morphology and follow-up

(2010) Moira Ragazzi et al.   HUMAN PATHOLOGY

SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells

(2010) Tong SHI et al.   Journal of Digestive Diseases

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Fluorescence Lifetime Imaging of Endogenous Fluorophores in Histopathology Sections Reveals Differences Between Normal and Tumor Epithelium in Carcinoma In Situ of the Breast

(2009) Matthew W. Conklin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA variant interactions modify breast cancer risk

(2008) Daniel Covarrubias et al.   JOURNAL OF HUMAN GENETICS

Proteomics-Based Identification of HSP60 as a Tumor-Associated Antigen in Early Stage Breast Cancer and Ductal Carcinomain situ

(2008) C. Desmetz et al.   JOURNAL OF PROTEOME RESEARCH

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE