Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

Metabolic vulnerability of cisplatin‐resistant cancers

(2018) Florine Obrist et al.   EMBO JOURNAL

Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage

(2017) Xuanye Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells

(2017) Fintan Geoghegan et al.   Oncotarget

Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism

(2016) Zhihong Ai et al.   CANCER LETTERS

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

(2016) Robert Gustafsson et al.   CANCER RESEARCH

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies

(2015) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin

(2013) D. H. Shin et al.   CANCER RESEARCH

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases

(2011) Matthew D. Hirschey   Cell Metabolism

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Autoacetylation of the Histone Acetyltransferase Rtt109

(2011) Brittany N. Albaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

The SirT3 Divining Rod Points to Oxidative Stress

(2011) Eric L. Bell et al.   MOLECULAR CELL

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Redox Signaling Across Cell Membranes

(2008) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology