Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis

Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis

(2020) Russel J. Reiter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

(2020) Zihan Li et al.   Nature Communications

Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration

(2020) Carmen Rodríguez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial dysfunction in metabolic syndrome

(2020) Pankaj Prasun   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

(2020) Xingyou Wan et al.   Cell Death & Disease

Melatonin and Docosahexaenoic Acid Decrease Proliferation of PNT1A Prostate Benign Cells via Modulation of Mitochondrial Bioenergetics and ROS Production

(2019) Guilherme H. Tamarindo et al.   Oxidative Medicine and Cellular Longevity

Melatonin Increases Brown Adipose Tissue Volume and Activity in Melatonin Deficient Patients: a Proof-of-Concept Study

(2019) Bruno Halpern et al.   DIABETES

Melatonin suppresses lung cancer metastasis by inhibition of epithelial–mesenchymal transition through targeting to Twist

(2019) Chia-Chia Chao et al.   CLINICAL SCIENCE

SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

(2019) Lei Xu et al.   Cancer Medicine

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Systemic Therapy for Locally Advanced and Metastatic Non–Small Cell Lung Cancer

(2019) Kathryn C. Arbour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influence of Daytime LED Light Exposure on Circadian Regulatory Dynamics of Metabolism and Physiology in Mice

(2019) Robert T Dauchy et al.   COMPARATIVE MEDICINE

Hepatitis C Virus Downregulates Core Subunits of Oxidative Phosphorylation, Reminiscent of the Warburg Effect in Cancer Cells

(2019) Gerresheim et al.   Cells

PLK1 and EGFR targeted nanoparticle as a radiation sensitizer for non-small cell lung cancer

(2019) Moataz Reda et al.   CANCER LETTERS

Chemotherapy remains a cornerstone in the treatment of nonsmall cell lung cancer

(2019) Robert Pirker   CURRENT OPINION IN ONCOLOGY

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

(2018) Chris Carrico et al.   Cell Metabolism

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells

(2018) Zhenlong Yu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and Cancer Hallmarks

(2018) Wamidh Talib   MOLECULES

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Multiple primary lung cancer: A literature review

(2018) Anna Romaszko et al.   Advances in Clinical and Experimental Medicine

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

(2018) Sungmi Park et al.   Diabetes & Metabolism Journal

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

(2018) Yuxiang Zheng et al.   CELL

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

(2018) Zhen Wei et al.   Nature Communications

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

(2017) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

(2017) Zuzana Keckesova et al.   NATURE

Lactic Acid: No Longer an Inert and End-Product of Glycolysis

(2017) Shiren Sun et al.   PHYSIOLOGY

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

The role of sex hormones and steroid receptors on female reproductive cancers

(2017) Luiz Gustavo de Almeida Chuffa et al.   STEROIDS

S100P enhances the chemosensitivity of human gastric cancer cell lines

(2017) Xiaomu Zhao et al.   Cancer Biomarkers

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

(2016) Carolina Doerrier et al.   MITOCHONDRION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Melatonin as a potential anticarcinogen for non-small-cell lung cancer

(2016) Zhiqiang Ma et al.   Oncotarget

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

(2016) Ozkan Ozden et al.   Aging-US

An efficient statistical approach for time synchronization in wireless sensor networks

(2015) Aditi Chatterjee et al.   INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells

(2015) Ana M. Sanchez-Sanchez et al.   PLoS One

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention

(2014) David E. Blask et al.   PLoS One

BMP4 is Involved in the Chemoresistance of Myeloid Leukemia Cells Through Regulating Autophagy–Apoptosis Balance

(2013) Xielan Zhao et al.   CANCER INVESTIGATION

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mini-review on Glycolysis and Cancer

(2013) M. Akram   JOURNAL OF CANCER EDUCATION

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinoma

(2013) XIN ZHAO et al.   Oncology Letters

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases

(2012) Peter W. Stacpoole   AGING CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells

(2011) Ana M. Sánchez-Sánchez et al.   FREE RADICAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA