Engineering Organ-on-a-Chip to Accelerate Translational Research

3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert

(2022) Woojung Shin et al.   Nature Protocols

3D micromesh-based hybrid bioprinting: multidimensional liquid patterning for 3D microtissue engineering

(2022) Byungjun Lee et al.   NPG Asia Materials

Organ-On-A-Chip: A Survey of Technical Results and Problems

(2022) Alex Ede Danku et al.   Frontiers in Bioengineering and Biotechnology

A new insight into a thermoplastic microfluidic device aimed at improvement of oxygenation process and avoidance of shear stress during cell culture

(2022) Zohreh Sheidaei et al.   BIOMEDICAL MICRODEVICES

Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip

(2022) Hyunho Kim et al.   Advanced Science

A multi-organ chip with matured tissue niches linked by vascular flow

(2022) Kacey Ronaldson-Bouchard et al.   Nature Biomedical Engineering

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

(2022) Raquel E. Ajalik et al.   Frontiers in Bioengineering and Biotechnology

Anchor‐IMPACT: A standardized microfluidic platform for high‐throughput antiangiogenic drug screening

(2021) Suryong Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip

(2021) Sumin Kim et al.   BIOMATERIALS

Vascularization of iNSC spheroid in a 3D spheroid‐on‐a‐chip platform enhances neural maturation

(2021) Nari Shin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Adoption of organ-on-chip platforms by the pharmaceutical industry

(2021) Paul Vulto et al.   NATURE REVIEWS DRUG DISCOVERY

Design and Fabrication of Organ-on-Chips: Promises and Challenges

(2021) Alireza Tajeddin et al.   Micromachines

Anti-Cancer Drug Screening with Microfluidic Technology

(2021) Mojdeh Monjezi et al.   Applied Sciences-Basel

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Pneumatically Actuated Microfluidic Platform for Reconstituting 3D Vascular Tissue Compression

(2020) Jungho Ahn et al.   Applied Sciences-Basel

Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model

(2020) Kristina Haase et al.   ADVANCED FUNCTIONAL MATERIALS

Organ-on-a-chip engineering: Toward bridging the gap between lab and industry

(2020) Qasem Ramadan et al.   Biomicrofluidics

Beyond polydimethylsiloxane: Alternative materials for fabrication of organ on a chip devices and microphysiological systems

(2020) Scott Campbell et al.   ACS Biomaterials-Science & Engineering

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

(2020) Xin Cui et al.   eLife

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform

(2020) Cynthia Hajal et al.   BIOMATERIALS

Human biomimetic liver microphysiology systems in drug development and precision medicine

(2020) Albert Gough et al.   Nature Reviews Gastroenterology & Hepatology

Recent advances in microfluidic technology and applications for anti-cancer drug screening

(2020) Yiwei Shi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models

(2020) Clare L. Thompson et al.   Frontiers in Bioengineering and Biotechnology

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma

(2019) José A. Jiménez-Torres et al.   EBioMedicine

Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes

(2019) Yang Xiao et al.   Advanced Science

Automated microfluidic cell culture of stem cell derived dopaminergic neurons

(2019) Khalid I. W. Kane et al.   Scientific Reports

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

(2019) María Virumbrales-Muñoz et al.   Scientific Reports

High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform)

(2019) Dohyun Park et al.   Frontiers in Immunology

Load-induced osteoarthritis on a chip

(2019) Riccardo Gottardi   Nature Biomedical Engineering

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

(2019) Michelle Maurer et al.   BIOMATERIALS

Engineered skeletal muscles for disease modeling and drug discovery

(2019) Jason Wang et al.   BIOMATERIALS

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

(2019) Yuji Nashimoto et al.   BIOMATERIALS

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

(2019) Olya Mastikhina et al.   BIOMATERIALS

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

(2019) Somin Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening

(2018) Jungho Ahn et al.   ADVANCED DRUG DELIVERY REVIEWS

Drug-Induced Nephrotoxicity: Pathogenic Mechanisms, Biomarkers and Prevention Strategies

(2018) Huizi Wu et al.   CURRENT DRUG METABOLISM

Microfluidics within a well: an injection-molded plastic array 3D culture platform

(2018) Younggyun Lee et al.   LAB ON A CHIP

UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems

(2018) Ying I. Wang et al.   LAB ON A CHIP

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice

(2018) Zhongyu Li et al.   TOXICOLOGY IN VITRO

Bioinks for 3D bioprinting: an overview

(2018) P. Selcan Gungor-Ozkerim et al.   Biomaterials Science

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development

(2018) Samuel Sances et al.   Stem Cell Reports

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform

(2018) V. van Duinen et al.   ANGIOGENESIS

Microfluidic-based vascularized microphysiological systems

(2018) Somin Lee et al.   LAB ON A CHIP

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip

(2018) Woojung Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

(2018) Marcia A. M. M. Ferraz et al.   Nature Communications

Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models

(2018) Mario Rothbauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials-Science & Engineering

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials Science & Engineering

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

3D-Printed Microfluidics

(2016) Anthony K. Au et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell sources for in vitro human liver cell culture models

(2016) Katrin Zeilinger et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Rapid Mechanically Controlled Rewiring of Neuronal Circuits

(2016) M. H. Magdesian et al.   JOURNAL OF NEUROSCIENCE

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model

(2016) Sudong Kim et al.   LAB ON A CHIP

Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview

(2016) Divya Singh et al.   Frontiers in Physiology

High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform

(2016) Gregory J. Nierode et al.   Stem Cell Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector

(2015) Jie Zhang et al.   BIOSENSORS & BIOELECTRONICS

Large scale patterning of hydrogel microarrays using capillary pinning

(2015) Burcu Gumuscu et al.   LAB ON A CHIP

Oxygen control with microfluidics

(2014) Martin D. Brennan et al.   LAB ON A CHIP

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

(2013) Goran T. Vladisavljević et al.   ADVANCED DRUG DELIVERY REVIEWS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment

(2013) Hon Fai Chan et al.   Scientific Reports

Droplet Microfluidics-A Tool for Single-Cell Analysis

(2012) Haakan N. Joensson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug-Induced Nephrotoxicity and Its Biomarkers

(2012) Sun-Young Kim et al.   Biomolecules & Therapeutics

Fluid flows and forces in development: functions, features and biophysical principles

(2012) J. B. Freund et al.   DEVELOPMENT

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Phaseguides: a paradigm shift in microfluidic priming and emptying

(2011) Paul Vulto et al.   LAB ON A CHIP

Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection

(2011) Sifeng Mao et al.   LAB ON A CHIP

Capillary Based Patterning of Cellular Communities in Laterally Open Channels

(2010) Sung Hoon Lee et al.   ANALYTICAL CHEMISTRY

Biological applications of microfluidic gradient devices

(2010) Sudong Kim et al.   Integrative Biology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Droplet microfluidics

(2008) Shia-Yen Teh et al.   LAB ON A CHIP