The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform

The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation

(2020) Mark F. Coughlin et al.   Advanced Healthcare Materials

MiR-6875-3p promotes the proliferation, invasion and metastasis of hepatocellular carcinoma via BTG2/FAK/Akt pathway

(2019) Yingjun Xie et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Cancer cells in the tumor core exhibit spatially coordinated migration patterns

(2019) Ralitza Staneva et al.   JOURNAL OF CELL SCIENCE

Microfabricated blood vessels for modeling the vascular transport barrier

(2019) William J. Polacheck et al.   Nature Protocols

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation

(2019) Jorge Escribano et al.   PLoS Computational Biology

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

(2019) Lindsay Angus et al.   NATURE GENETICS

Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution

(2019) Giovanni S. Offeddu et al.   Small

Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF‐Ang‐Tie2 Signaling

(2019) Kristina Haase et al.   Advanced Science

Lymphatic System Flows

(2018) James E. Moore et al.   Annual Review of Fluid Mechanics

Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

(2018) Gautier Follain et al.   DEVELOPMENTAL CELL

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications

(2017) Yiming Lei et al.   PROGRESS IN NEUROBIOLOGY

Fluid shear stress activates YAP1 to promote cancer cell motility

(2017) Hyun Jung Lee et al.   Nature Communications

Elucidation of the Roles of Tumor Integrin  1 in the Extravasation Stage of the Metastasis Cascade

(2016) M. B. Chen et al.   CANCER RESEARCH

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

(2016) Alexandra S. Piotrowski-Daspit et al.   Integrative Biology

Biomechanics of vascular mechanosensation and remodeling

(2016) Nicolas Baeyens et al.   MOLECULAR BIOLOGY OF THE CELL

Modes of cancer cell invasion and the role of the microenvironment

(2015) Andrew G Clark et al.   CURRENT OPINION IN CELL BIOLOGY

An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

(2015) M. Pisano et al.   Integrative Biology

Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

(2014) P Wang et al.   ONCOGENE

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism

(2012) J. M. Munson et al.   CANCER RESEARCH

Artificial lymphatic drainage systems for vascularized microfluidic scaffolds

(2012) Keith H. K. Wong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

In vivo blood flow and wall shear stress measurements in the vitelline network

(2008) C. Poelma et al.   EXPERIMENTS IN FLUIDS