Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery
Authors
Keywords
-
Journal
Frontiers in Bioengineering and Biotechnology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-03-14
DOI
10.3389/fbioe.2022.846230
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis
- (2021) Chia-Lung Wu et al. Nature Communications
- Trabecular bone organoid model for studying the regulation of localized bone remodeling
- (2021) Yongkuk Park et al. Science Advances
- Mechanism and reversal of drug-induced nephrotoxicity on a chip
- (2021) Aaron Cohen et al. Science Translational Medicine
- Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue
- (2021) Mark J. Mondrinos et al. Science Advances
- Microphysiological systems: What it takes for community adoption
- (2021) Passley Hargrove-Grimes et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Modeling Joint Pain on a Chip: integrating sensory neurons in the microJoint to model osteoarthritis
- (2021) Jamie Moy et al. JOURNAL OF PAIN
- Measurement of respiration and acidification rates of mammalian cells in thermoplastic microfluidic devices
- (2021) Bernhard Müller et al. SENSORS AND ACTUATORS B-CHEMICAL
- Synovial macrophages: from ordinary eaters to extraordinary multitaskers
- (2021) Nicole Hannemann et al. TRENDS IN IMMUNOLOGY
- Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
- (2021) Andrea De Pieri et al. npj Regenerative Medicine
- Lab-on-a-chip based mechanical actuators and sensors for single-cell and organoid culture studies
- (2021) Jaan Männik et al. JOURNAL OF APPLIED PHYSICS
- Recapitulating monocyte extravasation to the synovium in an organotypic microfluidic model of the articular joint
- (2021) Carlotta Mondadori et al. Biofabrication
- Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
- (2021) João D. Pereira et al. Nature Communications
- Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
- (2021) Taiki Nakajima et al. Nature Communications
- In Vitro Strategies to Vascularize 3D Physiologically Relevant Models
- (2021) Alessandra Dellaquila et al. Advanced Science
- Morphine-sensitive synaptic transmission emerges in embryonic rat microphysiological model of lower afferent nociceptive signaling
- (2021) Kevin J. Pollard et al. Science Advances
- Trabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration
- (2021) Alexandra Iordachescu et al. NPJ Microgravity
- Self-Organizing 3D Human Trunk Neuromuscular Organoids
- (2020) Jorge-Miguel Faustino Martins et al. Cell Stem Cell
- On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
- (2020) Tatsuya Osaki et al. Nature Protocols
- Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions
- (2020) Yulin Jiang et al. NPG Asia Materials
- On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
- (2020) David B. Chou et al. Nature Biomedical Engineering
- The role of the macrophage in tendinopathy and tendon healing
- (2020) Joo Y. Sunwoo et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors
- (2020) Emily C. Wheeler et al. NATURE METHODS
- A 96-well culture platform enables longitudinal analyses of engineered human skeletal muscle microtissue strength
- (2020) Mohammad E. Afshar et al. Scientific Reports
- Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip
- (2020) Trevor Sasserath et al. Advanced Science
- Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage
- (2020) Carlo Alberto Paggi et al. SENSORS AND ACTUATORS B-CHEMICAL
- Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers
- (2020) Denise Zujur et al. Regenerative Therapy
- Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration
- (2020) David Chen et al. Science Translational Medicine
- The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis
- (2020) Pedro M. Rodríguez Cruz et al. Frontiers in Molecular Neuroscience
- Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
- (2020) Clare L. Thompson et al. Frontiers in Bioengineering and Biotechnology
- Biohybrid valveless pump-bot powered by engineered skeletal muscle
- (2019) Zhengwei Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury
- (2019) Joseph R. Hsu et al. JOURNAL OF ORTHOPAEDIC TRAUMA
- A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
- (2019) Yimu Zhao et al. CELL
- The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database
- (2019) Eden Sebbag et al. ANNALS OF THE RHEUMATIC DISEASES
- Concise Review: Mesenchymal Stem Cells: From Roots to Boost
- (2019) Anna Andrzejewska et al. STEM CELLS
- A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction
- (2019) Mohsen Afshar Bakooshli et al. eLife
- Bone-chip system to monitor osteogenic differentiation using optical imaging
- (2019) Dmitriy Sheyn et al. Microfluidics and Nanofluidics
- Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells
- (2019) Andrea Manfrin et al. NATURE METHODS
- Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives
- (2019) Xu Cao et al. Stem Cell Reports
- Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
- (2019) Paola Occhetta et al. Nature Biomedical Engineering
- Locally renewing resident synovial macrophages provide a protective barrier for the joint
- (2019) Stephan Culemann et al. NATURE
- Deconstructed Microfluidic Bone Marrow On‐A‐Chip to Study Normal and Malignant Hemopoietic Cell–Niche Interactions
- (2019) Julio Aleman et al. Small
- Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption
- (2019) Emi Sano et al. Micromachines
- Computational fluid dynamic analysis of bioprinted self‐supporting perfused tissue models
- (2019) T. J. Sego et al. BIOTECHNOLOGY AND BIOENGINEERING
- Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells
- (2019) Alessandro Pirosa et al. Stem Cell Research & Therapy
- Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs
- (2019) Zixuan Lin et al. Frontiers in Bioengineering and Biotechnology
- Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development
- (2018) Martin Raasch et al. ADVANCED DRUG DELIVERY REVIEWS
- Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs
- (2018) Christopher R. Rowland et al. BIOMATERIALS
- Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis
- (2018) Tatsuya Osaki et al. BIOMATERIALS
- Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics
- (2018) Navaneetha Santhanam et al. BIOMATERIALS
- A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix
- (2018) Matthew Walker et al. BIOMEDICAL MICRODEVICES
- Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection
- (2018) Francesco Boccellato et al. GUT
- A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array
- (2018) Sehoon Jeong et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Integrating soft and hard tissues via interface tissue engineering
- (2018) Sahishnu Patel et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Use of porous membranes in tissue barrier and co-culture models
- (2018) Henry H. Chung et al. LAB ON A CHIP
- Pneumatic microfluidic cell compression device for high-throughput study of chondrocyte mechanobiology
- (2018) Donghee Lee et al. LAB ON A CHIP
- Organoids
- (2018) Natalie de Souza NATURE METHODS
- Human bone perivascular niche-on-a-chip for studying metastatic colonization
- (2018) Alessandro Marturano-Kruik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells
- (2018) Sijie Hao et al. Small
- Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion
- (2018) Xiaokang Li et al. Small
- Engineering human pluripotent stem cells into a functional skeletal muscle tissue
- (2018) Lingjun Rao et al. Nature Communications
- Engineering a multicellular vascular niche to model hematopoietic cell trafficking
- (2018) Surya S. Kotha et al. Stem Cell Research & Therapy
- Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle
- (2018) Alastair Khodabukus et al. BIOMATERIALS
- Progress and potential in organoid research
- (2018) Giuliana Rossi et al. NATURE REVIEWS GENETICS
- Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling
- (2018) Fabio Bianchi et al. Stem Cell Research
- Engineering and monitoring cellular barrier models
- (2018) Jose Yeste et al. Journal of Biological Engineering
- Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
- (2018) Gráinne M. Cunniffe et al. BIOMATERIALS
- Towards the development of human immune-system-on-a-chip platforms
- (2018) Alessandro Polini et al. DRUG DISCOVERY TODAY
- Small Force, Big Impact: Next Generation Organ-on-a-Chip Systems Incorporating Biomechanical Cues
- (2018) Ece Ergir et al. Frontiers in Physiology
- Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during fluid shear stress mechanostimulation
- (2017) K. Middleton et al. JOURNAL OF BIOMECHANICS
- New MSC: MSCs as pericytes are Sentinels and gatekeepers
- (2017) Arnold I. Caplan JOURNAL OF ORTHOPAEDIC RESEARCH
- Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury
- (2017) Gaurav Agrawal et al. LAB ON A CHIP
- Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function
- (2017) Olivier Y. F. Henry et al. LAB ON A CHIP
- Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions
- (2017) Ricardo Cruz-Acuña et al. MATRIX BIOLOGY
- On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics
- (2017) Michelle B Chen et al. Nature Protocols
- Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
- (2017) Yu Shrike Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices
- (2016) Seyed Ali Mousavi Shaegh et al. Biomicrofluidics
- A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility
- (2016) Alexander P. Nesmith et al. JOURNAL OF CELL BIOLOGY
- AAOS Research Symposium Updates and Consensus
- (2016) Robert F. LaPrade et al. JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
- Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
- (2016) Anna Marsano et al. LAB ON A CHIP
- 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout
- (2016) Aereas Aung et al. LAB ON A CHIP
- Cell stretching devices as research tools: engineering and biological considerations
- (2016) Harshad Kamble et al. LAB ON A CHIP
- Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
- (2016) Danny Bavli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone
- (2015) Sebastian Prill et al. ARCHIVES OF TOXICOLOGY
- Stress as a fundamental theme in cell plasticity
- (2015) Ofer Shoshani et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms
- (2015) Elishai Ezra et al. BIOMEDICAL MICRODEVICES
- A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions
- (2015) E. E. Zahavi et al. JOURNAL OF CELL SCIENCE
- Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
- (2015) Christoph Patsch et al. NATURE CELL BIOLOGY
- Organs-on-chips at the frontiers of drug discovery
- (2015) Eric W. Esch et al. NATURE REVIEWS DRUG DISCOVERY
- Microfluidic-assisted cyclic mechanical stimulation affects cellular membrane integrity in a human muscular dystrophy in vitro model
- (2015) F. Michielin et al. RSC Advances
- Biosensor Regeneration: A Review of Common Techniques and Outcomes
- (2014) J. A. Goode et al. LANGMUIR
- Clinical development success rates for investigational drugs
- (2014) Michael Hay et al. NATURE BIOTECHNOLOGY
- Microfluidic organs-on-chips
- (2014) Sangeeta N Bhatia et al. NATURE BIOTECHNOLOGY
- Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
- (2014) Jessie S. Jeon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human myotendinous junction: An ultrastructural and 3D analysis study
- (2014) A. B. Knudsen et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Fixing problems with cell lines
- (2014) Jon R. Lorsch et al. SCIENCE
- Materials for Microfluidic Chip Fabrication
- (2013) Kangning Ren et al. ACCOUNTS OF CHEMICAL RESEARCH
- Mechanobiology and Developmental Control
- (2013) Tadanori Mammoto et al. Annual Review of Cell and Developmental Biology
- One load to rule them all: Mechanical control of the musculoskeletal system in development and aging
- (2013) Yulia Shwartz et al. DIFFERENTIATION
- Microfabricated mammalian organ systems and their integration into models of whole animals and humans
- (2013) Jong H. Sung et al. LAB ON A CHIP
- Engineering of functional, perfusable 3D microvascular networks on a chip
- (2013) Sudong Kim et al. LAB ON A CHIP
- BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
- (2012) L. M. Griep et al. BIOMEDICAL MICRODEVICES
- Induced pluripotent stem cells: the new patient?
- (2012) Milena Bellin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
- (2012) Sang-Hyug Park et al. PLoS One
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Reconstituting Organ-Level Lung Functions on a Chip
- (2010) D. Huh et al. SCIENCE
- Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site
- (2009) Xiaoran Li et al. NANO LETTERS
- Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
- (2008) Stuart H. Orkin et al. CELL
- A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs
- (2008) Mihaela Crisan et al. Cell Stem Cell
- Engineering graded tissue interfaces
- (2008) J. E. Phillips et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search