Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

(2018) Jelle J. F. Sleeboom et al.   Disease Models & Mechanisms

Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model

(2018) Molly M. Morgan et al.   Scientific Reports

Engineered 3D vascular and neuronal networks in a microfluidic platform

(2018) Tatsuya Osaki et al.   Scientific Reports

Cdc42 regulates branching in angiogenic sprouting in vitro

(2017) Duc-Huy T. Nguyen et al.   MICROCIRCULATION

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models

(2017) María Virumbrales-Muñoz et al.   Scientific Reports

Effects of ADMA on gene expression and metabolism in serum-starved LoVo cells

(2016) Ningning Zheng et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Microfluidic Platform for Studying Chemotaxis of Adhesive Cells Revealed a Gradient-Dependent Migration and Acceleration of Cancer Stem Cells

(2015) Heng Zou et al.   ANALYTICAL CHEMISTRY

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining

(2015) Sabine Pietkiewicz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations

(2015) Yu-Chih Chen et al.   Scientific Reports

SU-8 Based Microdevices to Study Self-Induced Chemotaxis in 3D Microenvironments

(2015) Jose Maria Ayuso et al.   Frontiers in Materials

MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels

(2015) Marguerite M. Vantangoli et al.   PLoS One

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model

(2015) Toshiyuki Tsunoda et al.   NEOPLASIA

Engineered three-dimensional microfluidic device for interrogating cell-cell interactions in the tumor microenvironment

(2014) K. Hockemeyer et al.   Biomicrofluidics

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Dimethyl Sulfoxide Damages Mitochondrial Integrity and Membrane Potential in Cultured Astrocytes

(2014) Chan Yuan et al.   PLoS One

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic tumor microenvironment on a microfluidic platform

(2013) Huipeng Ma et al.   Biomicrofluidics

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Cooperative Roles of SDF-1α and EGF Gradients on Tumor Cell Migration Revealed by a Robust 3D Microfluidic Model

(2013) Beum Jun Kim et al.   PLoS One

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Integration of intra- and extravasation in one cell-based microfluidic chip for the study of cancer metastasis

(2011) Min Kyeong Shin et al.   LAB ON A CHIP

Serum-Nutrient Starvation Induces Cell Death Mediated by Bax and Puma That Is Counteracted by p21 and Unmasked by Bcl-xL Inhibition

(2011) Frédérique Braun et al.   PLoS One

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

Conventional apoptosis assays using propidium iodide generate a significant number of false positives that prevent accurate assessment of cell death

(2010) Aja M. Rieger et al.   JOURNAL OF IMMUNOLOGICAL METHODS

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies

(2009) Ulrike Haessler et al.   BIOMEDICAL MICRODEVICES

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

(2007) Richard Lock et al.   PEDIATRIC BLOOD & CANCER