Pharmacological Approaches to Decelerate Aging: A Promising Path

Epigenetics of Aging and Aging-Associated Diseases

(2021) Dominik Saul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment

(2021) Sareer Ahmad et al.   Frontiers in Pharmacology

How metformin affects various malignancies by means of microRNAs: a brief review

(2021) Nahid Alimoradi et al.   Cancer Cell International

The central role of DNA damage in the ageing process

(2021) Björn Schumacher et al.   NATURE

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

(2021) Mengdi Yu et al.   Cells

The Gut Microbiome, Metformin, and Aging

(2021) Sri Nitya Reddy Induri et al.   Annual Review of Pharmacology and Toxicology

Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs

(2021) Nahid Alimoradi et al.   BIOMEDICINE & PHARMACOTHERAPY

Mini-review: The anti-aging effects of lithium in bipolar disorder

(2021) Erika M. Salarda et al.   NEUROSCIENCE LETTERS

Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases

(2021) Dan-Dan Zhou et al.   Oxidative Medicine and Cellular Longevity

Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

(2021) Arun Reddy Ravula et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity

(2021) Katharina Jans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration

(2021) Zhen Wang et al.   Frontiers in Molecular Biosciences

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

(2020) Li Liu et al.   Cancers

Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition PIM-1 kinase activity

(2020) Sujin Kim et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Impact of calorie restriction on energy metabolism in humans

(2020) Jasper Most et al.   EXPERIMENTAL GERONTOLOGY

SIRT1 and aging related signaling pathways

(2020) Cui Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of cellular senescence in ageing and endocrine disease

(2020) Sundeep Khosla et al.   Nature Reviews Endocrinology

Nutritional Aspects of Spermidine

(2020) Frank Madeo et al.   Annual Review of Nutrition

SIRT1 Activation by Natural Phytochemicals: An Overview

(2020) Concetta Iside et al.   Frontiers in Pharmacology

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

(2020) Natalia Mota-Martorell et al.   GeroScience

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

(2020) Paul D. Robbins et al.   Annual Review of Pharmacology and Toxicology

Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder

(2020) Martin Lundberg et al.   Frontiers in Psychiatry

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

(2019) Munehiro Kitada et al.   Frontiers in Endocrinology

Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis

(2019) Tao Zhang et al.   MEDICAL SCIENCE MONITOR

Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells

(2019) Ligen Du et al.   Drug Design Development and Therapy

Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks

(2019) Rüdiger Hardeland   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity

(2019) Galina V. Morgunova et al.   CELL BIOCHEMISTRY AND FUNCTION

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway

(2019) Li Yuan et al.   Molecular Medicine Reports

Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity

(2019) Shambhoo Sharan Tripathi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies

(2019) Gerben van Hameren et al.   Acta Neuropathologica Communications

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Metformin and Aging: A Review

(2019) Hartmut H. Glossmann et al.   GERONTOLOGY

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice

(2019) Wang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The gut microbiome in neurological disorders

(2019) John F Cryan et al.   LANCET NEUROLOGY

Measuring biological aging in humans: A quest

(2019) Luigi Ferrucci et al.   AGING CELL

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

(2019) Bingren Tian et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

(2018) Ameya S Kulkarni et al.   AGING CELL

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

(2018) Jingqi Fang et al.   AGING CELL

Insulin-like growth factor-1 signaling in cardiac aging

(2018) Wang-Soo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice

(2018) Mohammad Reza Dorvash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway

(2018) Yu Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

(2018) Sandeep Singh et al.   LIFE SCIENCES

Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

(2018) Bo Yang et al.   Molecular Medicine Reports

Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions

(2018) Russel Reiter et al.   MOLECULES

Histone Modifications in Aging: The Underlying Mechanisms and Implications

(2018) Yuan Wang et al.   Current Stem Cell Research & Therapy

Spermidine delays aging in humans

(2018) Frank Madeo et al.   Aging-US

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

(2018) Hannah Walters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

(2018) Adam R. Konopka et al.   AGING CELL

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

(2017) Xiaojing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB

(2017) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

(2017) Antonio Currais et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

(2017) Luca Giovannini et al.   NUTRITION

Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans

(2017) Xiao-Bing Huang et al.   PLoS One

Physical activity and telomere length: Impact of aging and potential mechanisms of action

(2017) Nicole C. Arsenis et al.   Oncotarget

Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

(2017) Jingjing Fan et al.   Oncotarget

Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway

(2017) En-Xing Xue et al.   Oncotarget

Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

(2017) Cristy Phillips   NEURAL PLASTICITY

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

(2016) Ishita Parikh et al.   Aging-US

Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway

(2016) Bodong Wang et al.   BRAIN RESEARCH

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride

(2016) Xiaolong Gu et al.   Oncotarget

Mitochondrial dysfunction and oxidative stress in aging and cancer

(2016) Anna V. Kudryavtseva et al.   Oncotarget

Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan

(2016) Zoe E. Gillespie et al.   Frontiers in Genetics

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

(2016) Vladimir N. Anisimov et al.   Aging-US

Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

(2016) Amit Khanna et al.   Aging-US

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis

(2016) Maria Comas et al.   Aging-US

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

(2016) Carolina B. Livi et al.   Aging-US

Age-related changes in microRNA levels in serum

(2016) Nicole Noren Hooten et al.   Aging-US

Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1

(2016) Xiao-Zhi Bai et al.   Scientific Reports

Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial

(2015) Luigi Fontana et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells

(2015) Sang Chon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mortality associated with lithium and valproate treatment of US Veterans Health Administration patients with mental disorders

(2015) Eric G. Smith et al.   BRITISH JOURNAL OF PSYCHIATRY

Cellular senescence and the aging brain

(2015) Shankar J. Chinta et al.   EXPERIMENTAL GERONTOLOGY

Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis

(2015) J. Antoni Sirerol et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fisetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury via TLR4-Mediated NF-κB Signaling Pathway in Rats

(2015) Guang Feng et al.   INFLAMMATION

SIRT1 Protects Against Oxidative Stress-Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation

(2015) Yu-Qiang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of inflammation in the aging bones

(2015) Samir M. Abdelmagid et al.   LIFE SCIENCES

Immunosenescence: Implications for response to infection and vaccination in older people

(2015) Alejandra Pera et al.   MATURITAS

Reconfiguration of DNA methylation in aging

(2015) Michele Zampieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurocognitive Aging and the Hippocampus across Species

(2015) Stephanie L. Leal et al.   TRENDS IN NEUROSCIENCES

Comprehensive Catalog of Currently Documented Histone Modifications

(2015) Yingming Zhao et al.   Cold Spring Harbor Perspectives in Biology

Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells

(2015) Pei-Yi Chen et al.   Food & Function

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity

(2015) Anton Danilov et al.   Oncotarget

Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes

(2015) Yasuo Ido et al.   PLoS One

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

(2015) Kumsun Cho et al.   Scientific Reports

Lithium and Autophagy

(2014) Yumiko Motoi et al.   ACS Chemical Neuroscience

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Correlations Between Serum IL33 and Tumor Development: a Meta-analysis

(2014) Xiang-Jun Chen et al.   Asian Pacific Journal of Cancer Prevention

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

P53 and Sirt1: Routes of metabolism and genome stability

(2014) Stefania Gonfloni et al.   BIOCHEMICAL PHARMACOLOGY

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

(2014) Irina G Popovich et al.   CANCER BIOLOGY & THERAPY

Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

(2014) Jinsoo Seo et al.   CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

(2014) Gabriella Testa et al.   CURRENT PHARMACEUTICAL DESIGN

Cellular Senescence in Ageing, Age-Related Disease and Longevity

(2014) Ewa Sikora et al.   Current Vascular Pharmacology

Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

(2014) Nadège Minois   GERONTOLOGY

Tissue-specific insulin signaling in the regulation of metabolism and aging

(2014) Jingjing Zhang et al.   IUBMB LIFE

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

(2014) Vijayalekshmi Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence

(2014) Bidya Dhar Sahu et al.   PLoS One

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

(2014) Yue Hou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective

(2014) Qiu-Yi Choo et al.   Journal of Functional Foods

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

(2013) Antonio Currais et al.   AGING CELL

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span

(2013) Julia Marchal et al.   Annals of the New York Academy of Sciences

Protective effect of Pterostilbene against free radical mediated oxidative damage

(2013) Jhankar D Acharya et al.   BMC Complementary and Alternative Medicine

eRapa Restores a Normal Life Span in a FAP Mouse Model

(2013) P. Hasty et al.   Cancer Prevention Research

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

(2013) Anna Biason-Lauber et al.   Cell Metabolism

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

A Review of Pterostilbene Antioxidant Activity and Disease Modification

(2013) Denise McCormack et al.   Oxidative Medicine and Cellular Longevity

A complex interplay between PGC-1 co-activators and mTORC1 regulates hematopoietic recovery following 5-fluorouracil treatment

(2013) Sunanda Basu   Stem Cell Research

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

(2013) Kavitha Kannan et al.   Frontiers in Physiology

Fisetin: A Dietary Antioxidant for Health Promotion

(2012) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

(2012) Ulf Andersson Ørom et al.   CELL CYCLE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

MicroRNAs and their roles in aging

(2012) T. Smith-Vikos et al.   JOURNAL OF CELL SCIENCE

GH and IGF1: Roles in Energy Metabolism of Long-Living GH Mutant Mice

(2012) H. M. Brown-Borg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross Regulation of Sirtuin 1, AMPK, and PPARγ in Conjugated Linoleic Acid Treated Adipocytes

(2012) Shan Jiang et al.   PLoS One

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions

(2011) Bolin Liu et al.   CELL CYCLE

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

(2011) Yuanyuan Li et al.   PLoS One

Shelterin complex and associated factors at human telomeres

(2011) Raffaella Diotti et al.   Nucleus

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metformin Supplementation and Life Span in Fischer-344 Rats

(2010) D. L. Smith et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

The role of epigenetics in aging and age-related diseases

(2009) Vincenzo Calvanese et al.   AGEING RESEARCH REVIEWS

Effect of thymol and resveratrol administered with candy or syrup on the development ofNosema ceranaeand on the longevity of honeybees (Apis melliferaL.) in laboratory conditions

(2009) Cecilia Costa et al.   APIDOLOGIE

Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue

(2009) Iris C Maurer et al.   BIPOLAR DISORDERS

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

(2009) Narasimman Gurusamy et al.   CARDIOVASCULAR RESEARCH

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Rad As a Novel Regulator of Excitation–Contraction Coupling and β-Adrenergic Signaling in Heart

(2009) Gang Wang et al.   CIRCULATION RESEARCH

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin

(2009) Pamela Maher   Genes and Nutrition

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

(2008) Luigi Fontana et al.   AGING CELL

Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts

(2008) Jianhai Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

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