Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

miRNAs and aging: A genetic perspective

(2014) Devika Garg et al.   AGEING RESEARCH REVIEWS

Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity

(2014) Margret H. Bülow et al.   Scientific Reports

DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

(2014) Jennifer M. A. Tullet et al.   PLoS Genetics

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

(2013) Alessia Peserico et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition

(2013) Christian Günschmann et al.   DEVELOPMENTAL CELL

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

(2013) S. S. Franco et al.   HAEMATOLOGICA

Reduced epidermal thickness, nerve degeneration and increased pain-related behavior in rats with diabetes type 1 and 2

(2013) Matija Boric et al.   JOURNAL OF CHEMICAL NEUROANATOMY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

FOXO flips the longevity SWItch

(2013) Ashley E. Webb et al.   NATURE CELL BIOLOGY

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

(2013) Yusuke S. Hori et al.   PLoS One

Changes in epidermal thickness and cutaneous innervation during maturation in long-term diabetes

(2013) Antonia Jelicic Kadic et al.   Journal of Tissue Viability

Adrenergic signaling and oxidative stress: a role for sirtuins?

(2013) Graziamaria Corbi et al.   Frontiers in Physiology

Epidermal Stem Cells in Homeostasis and Wound Repair of the Skin

(2013) Makoto Senoo   Advances in Wound Care

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells

(2012) Lauren E. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial sirtuins and metabolic homeostasis

(2012) Eija Pirinen et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

(2012) X. Julia Xu et al.   JOURNAL OF LIPID RESEARCH

Facial Appearance Reflects Human Familial Longevity and Cardiovascular Disease Risk in Healthy Individuals

(2012) David A. Gunn et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development

(2012) Lindsay Peltz et al.   PLoS One

Acute Activation of AMP-Activated Protein Kinase Prevents H2O2-Induced Premature Senescence in Primary Human Keratinocytes

(2012) Yasuo Ido et al.   PLoS One

Insulin resistance due to nutrient excess

(2011) Asish K. Saha et al.   CELL CYCLE

Regulation of skin aging and heart development by TAp63

(2011) M Paris et al.   CELL DEATH AND DIFFERENTIATION

Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells

(2011) Roberta Castino et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

(2010) Mette Soerensen et al.   AGING CELL

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

Bioenergetics and the epigenome: Interface between the environment and genes in common diseases

(2010) Douglas C. Wallace   Developmental Disabilities Research Reviews

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Aging Epidermis Is Maintained by Changes in Transit-Amplifying Cell Kinetics, Not Stem Cell Kinetics

(2009) Michael C. Winter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bmi-1 Reduction Plays a Key Role in Physiological and Premature Aging of Primary Human Keratinocytes

(2009) Sonia Cordisco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Combination Treatment with Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells

(2009) Hao Jiang et al.   NEUROCHEMICAL RESEARCH

Why Some Women Look Young for Their Age

(2009) David A. Gunn et al.   PLoS One

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

(2008) Gabriela Suchankova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

(2008) Anna Mandinova et al.   EMBO JOURNAL

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

(2008) Heike Stachelscheid et al.   EMBO JOURNAL

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Adenosine 5′-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing’s Syndrome

(2008) Blerina Kola et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular senescence and organismal aging

(2008) Jessie C. Jeyapalan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA