Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 3, Pages 660
Publisher
MDPI AG
Online
2021-03-17
DOI
10.3390/cells10030660
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Acarbose improved survival for Apc +/Min mice
- (2020) Sherry G. Dodds et al. AGING CELL
- Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
- (2020) Xiaofeng Feng et al. Aging-US
- Aerobic Endurance Exercise Ameliorates Renal Vascular Sclerosis in Aged Mice by Regulating PI3K/AKT/mTOR Signaling Pathway
- (2020) Chuncha Bao et al. DNA AND CELL BIOLOGY
- Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways
- (2020) Hua Cai et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- The ageing epigenome and its rejuvenation
- (2020) Weiqi Zhang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
- (2020) Tamas Kiss et al. GeroScience
- Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
- (2020) Jing-Ying Lin et al. Aging-US
- NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
- (2020) Nady Braidy et al. EXPERIMENTAL GERONTOLOGY
- Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway
- (2020) Xia Zhao et al. Oxidative Medicine and Cellular Longevity
- Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging
- (2020) Young-Kyoung Ryu et al. NEUROPHARMACOLOGY
- Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis
- (2019) Zhiping Zhu et al. Aging-US
- mTOR: A Cellular Regulator Interface in Health and Disease
- (2019) Fahd Boutouja et al. Cells
- Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells
- (2019) Ligen Du et al. Drug Design Development and Therapy
- Metformin protects PC12 cells and hippocampal neurons from H2 O 2 -induced oxidative damage through activation of AMPK pathway
- (2019) Xia Zhao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Interval running training improves age‐related skeletal muscle wasting and bone loss: Experiments with ovariectomized rats
- (2019) Jeong‐Seok Kim et al. EXPERIMENTAL PHYSIOLOGY
- Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway
- (2019) Jun Huang et al. CNS Neuroscience & Therapeutics
- Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
- (2019) Hisayuki Amano et al. Cell Metabolism
- Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- (2019) Frank Madeo et al. Cell Metabolism
- Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity
- (2019) Galina V. Morgunova et al. CELL BIOCHEMISTRY AND FUNCTION
- Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence
- (2019) Kyeong Jin Yoon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease
- (2019) Zhihua Zhang et al. Aging-US
- Taming expectations of metformin as a treatment to extend healthspan
- (2019) Adam R. Konopka et al. GeroScience
- Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina
- (2019) Ning Wang et al. Aging-US
- Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway
- (2019) Yujie Huang et al. Aging-US
- SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy
- (2019) Jiaqi Pang et al. NEUROBIOLOGY OF AGING
- Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow
- (2019) Jie Song et al. Cell Death & Disease
- Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–Sirt1 signaling
- (2019) Chenchen Pi et al. Aging-US
- Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats
- (2019) Fang-Hui Li et al. Aging-US
- Proteomic Profile of Carbonylated Proteins Screen the Regulation of Calmodulin-Dependent Protein Kinases-AMPK-Beclin1 in Aerobic Exercise-Induced Autophagy in Middle-Aged Rat Hippocampus
- (2019) Wenfeng Liu et al. GERONTOLOGY
- Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK–mTOR Signaling Pathway in Aged Female Rats
- (2019) Jing Li et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- The effects of metformin on age-related changes in the liver sinusoidal endothelial cell
- (2019) Nicholas J Hunt et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians
- (2019) Marta Iglesias et al. Stem Cell Reports
- Hypothalamic mTORC2 is essential for metabolic health and longevity
- (2019) Karthikeyani Chellappa et al. AGING CELL
- The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise
- (2019) Wenfeng Liu et al. EXPERIMENTAL GERONTOLOGY
- Poria cocus Wolf Extract Ameliorates Hepatic Steatosis through Regulation of Lipid Metabolism, Inhibition of ER Stress, and Activation of Autophagy via AMPK Activation
- (2019) Ji-Hyun Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 17β-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model
- (2019) Mehtab Khan et al. Cells
- Metformin as Anti-Aging Therapy: Is It for Everyone?
- (2019) Alexander A. Soukas et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
- (2019) Christina Lee Chung et al. GeroScience
- Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles
- (2019) Chiao-Nan Chen et al. GeroScience
- Current nutritional and pharmacological anti-aging interventions
- (2019) Manuel Ros et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach
- (2019) Yanfei Liu et al. Oxidative Medicine and Cellular Longevity
- Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk
- (2019) Yam Nath Paudel et al. PHARMACOLOGICAL RESEARCH
- Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy
- (2018) Bin Li et al. ACTA PHARMACOLOGICA SINICA
- Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice
- (2018) Dang Li et al. AGING CELL
- Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- (2018) Eun Nim Kim et al. Aging-US
- Caloric restriction effects on liver mTOR signaling are time-of-day dependent
- (2018) Richa Tulsian et al. Aging-US
- Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1
- (2018) Nuredin Bakhtiari et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA y mice
- (2018) Peng Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
- (2018) Kenneth Maiese BIOCHEMICAL SOCIETY TRANSACTIONS
- Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway
- (2018) Lingjie Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Inhibition of miR-20 promotes proliferation and autophagy in articular chondrocytes by PI3K/AKT/mTOR signaling pathway
- (2018) Weidong He et al. BIOMEDICINE & PHARMACOTHERAPY
- Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice
- (2018) Min Jo Kim et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Curcumin improves age-related and surgically induced osteoarthritis by promoting autophagy in mice
- (2018) Guowang Zhang et al. BIOSCIENCE REPORTS
- NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR
- (2018) Jun Yoshino et al. Cell Metabolism
- Cryo-EM structure of human mTOR complex 2
- (2018) Xizi Chen et al. CELL RESEARCH
- Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain
- (2018) V. Palomera-Ávalos et al. EXPERIMENTAL GERONTOLOGY
- Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri
- (2018) Shan Liu et al. FISH & SHELLFISH IMMUNOLOGY
- DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease
- (2018) Hanqing Chen et al. HEPATOLOGY
- Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway
- (2018) Seul Gi Kim et al. JOURNAL OF MEDICINAL FOOD
- Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra
- (2018) Ana Muñoz et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats
- (2018) Andrea Di Francesco et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome
- (2018) Jahahreeh Finley MEDICAL HYPOTHESES
- Aspirin Recapitulates Features of Caloric Restriction
- (2018) Federico Pietrocola et al. Cell Reports
- The AMPK/p27 Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
- (2018) James P. White et al. Stem Cell Reports
- Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo
- (2018) Qiu-Xia Liang et al. Aging-US
- Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy
- (2018) Shuyi Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis
- (2018) Ming Zhao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats
- (2018) Fabricio M. Locatelli et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression
- (2018) Wei Yu et al. Molecular Medicine Reports
- Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
- (2018) Kurt A. Escobar et al. AGING CELL
- Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
- (2018) Beiyun Wang et al. Aging-US
- Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy
- (2018) Buhui Liu et al. Aging-US
- Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
- (2018) Wei-Kung Chen et al. Aging-US
- An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
- (2018) Yijie Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress
- (2018) Monika Kosztelnik et al. FASEB JOURNAL
- Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway
- (2018) Jiung-Pang Huang et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
- (2018) Hu Huang et al. JOURNAL OF CLINICAL INVESTIGATION
- A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model
- (2018) Jesus Campagna et al. Scientific Reports
- Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
- (2018) Yoomi Chun et al. Cells
- The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/Sirt1 pathway
- (2017) Zhi-Yin Liao et al. EXPERIMENTAL GERONTOLOGY
- Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice
- (2017) Cristina Ginés et al. EXPERIMENTAL GERONTOLOGY
- Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16
- (2017) Jin Young Sung et al. EXPERIMENTAL GERONTOLOGY
- The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
- (2017) Khoosheh Khayati et al. FASEB JOURNAL
- Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade
- (2017) Francesca Giampieri et al. FOOD CHEMISTRY
- mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
- (2017) Thomas Weichhart GERONTOLOGY
- Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts
- (2017) Satoshi Haramizu et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway
- (2017) Na Qin et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner
- (2017) Yi Guan et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPKα-FOXO1 signalling pathway in bovine intramuscular adipocytes
- (2017) Xiaomu Liu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Ginsenoside Rg1 Decreases Oxidative Stress and Down-Regulates Akt/mTOR Signalling to Attenuate Cognitive Impairment in Mice and Senescence of Neural Stem Cells Induced by d-Galactose
- (2017) Linbo Chen et al. NEUROCHEMICAL RESEARCH
- Aerobic exercise in adolescence results in an increase of neuronal and non-neuronal cells and in mTOR overexpression in the cerebral cortex of rats
- (2017) Angélica Begatti Victorino et al. NEUROSCIENCE
- The NAD+/PARP1/SIRT1 Axis in Aging
- (2017) Andrew R. Mendelsohn et al. REJUVENATION RESEARCH
- Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling
- (2017) Dan Dong et al. Oncotarget
- Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway
- (2017) Jingjing Fan et al. Oncotarget
- Dementia and aging populations—A global priority for contextualized research and health policy
- (2017) Carol Brayne et al. PLOS MEDICINE
- Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?
- (2017) Mohammad A. Kaisar et al. Redox Biology
- Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
- (2017) Peiguo Shi et al. Cell Discovery
- SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
- (2017) Kayvan Zainabadi et al. PLoS One
- Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway
- (2017) Chen-Wei Liu et al. Scientific Reports
- Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster
- (2017) Yasunari Kayashima et al. Scientific Reports
- Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
- (2016) Natalie E. de Picciotto et al. AGING CELL
- AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation
- (2016) Xiaojuan Han et al. AGING CELL
- Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways
- (2016) Lisa A. Lesniewski et al. AGING CELL
- Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions
- (2016) Ishita Parikh et al. Aging-US
- Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway
- (2016) Claire Rühlmann et al. Aging-US
- α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 ActivityHighlights
- (2016) Dong-Jie Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
- (2016) Masaki Igarashi et al. CELL
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
- (2016) Kathryn F. Mills et al. Cell Metabolism
- CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
- (2016) Juliana Camacho-Pereira et al. Cell Metabolism
- Exacerbated cardiac fibrosis induced by β-adrenergic activation in old mice due to decreased AMPK activity
- (2016) Jingjing Wang et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity
- (2016) Ting Luo et al. DIABETES
- Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts
- (2016) Junting Chen et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age
- (2016) Chi-Chang Huang et al. International Journal of Medical Sciences
- Molecular docking and CoMFA studies of thiazoloquin(az)olin(on)es as CD38 inhibitors: determination of inhibitory mechanism, pharmacophore interactions, and design of new inhibitors
- (2016) Bakhtyar Sepehri et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
- (2016) Antero Salminen et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging
- (2016) Koji Takayama et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor α
- (2016) Sun Ae Kim et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
- (2016) Sebastian I. Arriola Apelo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Inhibition of Advanced Glycation End Products (AGEs) Accumulation by Pyridoxamine Modulates Glomerular and Mesangial Cell Estrogen Receptor α Expression in Aged Female Mice
- (2016) Simone Pereira-Simon et al. PLoS One
- Genistein-induced LKB1–AMPK activation inhibits senescence of VSMC through autophagy induction
- (2016) Kyung Young Lee et al. VASCULAR PHARMACOLOGY
- Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
- (2016) Janete Cunha-Santos et al. Nature Communications
- Metformin: A Hopeful Promise in Aging Research
- (2016) Marta G. Novelle et al. Cold Spring Harbor Perspectives in Medicine
- Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
- (2016) A. Diman et al. Science Advances
- The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction
- (2016) Brenda Rascón et al. Aging-US
- Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis
- (2016) Vivek Kumar et al. Scientific Reports
- Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle
- (2015) Thomas K. Sin et al. ACTA DIABETOLOGICA
- β-Guanidinopropionic acid extends the lifespan ofDrosophila melanogastervia an AMP-activated protein kinase-dependent increase in autophagy
- (2015) Si Yang et al. AGING CELL
- Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver
- (2015) Ilona Zawada et al. Aging-US
- Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes
- (2015) Takumi Yokokawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- mTOR signaling in cellular and organismal energetics
- (2015) Verena Albert et al. CURRENT OPINION IN CELL BIOLOGY
- Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
- (2015) Karim Gariani et al. HEPATOLOGY
- Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors
- (2015) Curt D. Haffner et al. JOURNAL OF MEDICINAL CHEMISTRY
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1
- (2015) Juewon Kim et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Exercise Attenuates the Major Hallmarks of Aging
- (2015) Nuria Garatachea et al. REJUVENATION RESEARCH
- Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
- (2015) Stefania Rigacci et al. Oncotarget
- Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
- (2015) Dudley W. Lamming et al. Oncotarget
- Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes
- (2015) Yasuo Ido et al. PLoS One
- The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy
- (2015) Robert Siman et al. PLoS One
- AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels
- (2014) D. Grahame Hardie Annual Review of Nutrition
- mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits
- (2014) Fengying Yang et al. BEHAVIOURAL BRAIN RESEARCH
- The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
- (2014) Rafael de Cabo et al. CELL
- Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain
- (2014) Sergi Bayod et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress
- (2014) Xuan Ou et al. STEM CELLS
- AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
- (2014) Matthew Ulgherait et al. Cell Reports
- Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
- (2013) Akiko Satoh et al. Cell Metabolism
- Normal Cognitive Aging
- (2013) Caroline N. Harada et al. CLINICS IN GERIATRIC MEDICINE
- mTOR: more targets of resveratrol?
- (2013) Anne L. Widlund et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1
- (2013) Limin Han et al. Protein & Cell
- Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
- (2012) Protásio L. da Luz et al. ATHEROSCLEROSIS
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
- (2012) Nathan L. Price et al. Cell Metabolism
- Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
- (2012) C. Escande et al. DIABETES
- Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
- (2012) R. Strong et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
- (2012) Sifang Zhang et al. MECHANISMS OF AGEING AND DEVELOPMENT
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
- (2012) F. J. Ramos et al. Science Translational Medicine
- The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster
- (2011) Chunxu Wang et al. AGE
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- (2011) Antero Salminen et al. AGEING RESEARCH REVIEWS
- Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10
- (2011) Julio J. Ochoa et al. FREE RADICAL BIOLOGY AND MEDICINE
- Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
- (2011) Michel Bernier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR regulation of autophagy
- (2010) Chang Hwa Jung et al. FEBS LETTERS
- SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
- (2010) Hiyaa Singhee Ghosh et al. PLoS One
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
- (2010) Brian Onken et al. PLoS One
- Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
- (2009) Narasimman Gurusamy et al. CARDIOVASCULAR RESEARCH
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
- (2009) Brian M. Zid et al. CELL
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Caloric restriction, SIRT1 and longevity
- (2009) Carles Cantó et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
- (2008) Marcella Fulco et al. DEVELOPMENTAL CELL
- Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt
- (2008) Anita Y. M. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Estradiol and the Estradiol Metabolite, 2-Hydroxyestradiol, Activate AMP-activated Protein Kinase in C2C12 Myotubes
- (2008) Tara M. D'Eon et al. Obesity
- Exercise Training Promotes SIRT1 Activity in Aged Rats
- (2007) Nicola Ferrara et al. REJUVENATION RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More