Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1

Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis

(2015) Ali H. Amin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin prevents lung injury induced by hepatic ischemia–reperfusion through anti-inflammatory and anti-apoptosis effects

(2015) Li Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation

(2015) Song-Xue Guo et al.   Journal of Translational Medicine

A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

(2015) Do-Wan Shim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling

(2015) Xiaozhi Bai et al.   Scientific Reports

The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation

(2015) Juhyun Song et al.   Biomed Research International

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

(2014) Liyu He et al.   AMERICAN JOURNAL OF NEPHROLOGY

Melatonin: functions and ligands

(2014) Mahaveer Singh et al.   DRUG DISCOVERY TODAY

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury

(2014) Hong-Hwa Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol-A-induced apoptosis

(2014) Mohamed A. El-Missiry et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Melatonin inhibits thermal injury–induced hyperpermeability in microvascular endothelial cells

(2014) Katie Wiggins-Dohlvik et al.   Journal of Trauma and Acute Care Surgery

3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

(2013) Guoguo Shang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients

(2013) M. A. Dalboni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

The role of melatonin treatment in chronic kidney disease

(2012) Marije Russcher   Frontiers in Bioscience-Landmark

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney

(2011) Yukitoshi Sakao et al.   Clinical and Experimental Nephrology

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

(2010) Kazuhiro Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats

(2010) G. Bekyarova et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury

(2010) C.-H. Hsing et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury

(2009) Chengjin Gao et al.   BURNS

Acute kidney injury in critically ill burn patients. Risk factors, progression and impact on mortality

(2009) Tina Palmieri et al.   BURNS

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Protective effect of melatonin against oxidative hepatic injury after experimental thermal trauma

(2009) G. Bekyarova et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Oxidative Mechanisms of Brain Dysfunction During Sepsis

(2009) Felipe Dal-Pizzol et al.   NEUROCHEMICAL RESEARCH

Effects of melatonin in an experimental model of ventilator-induced lung injury

(2008) Paula R. Pedreira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY