Measuring biological age using omics data

Associations of Age, Sex, Race/Ethnicity and Education with 13 Epigenetic Clocks in a Nationally Representative US Sample: The Health and Retirement Study

(2021) Eileen M Crimmins et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy

(2021) David H. Meyer et al.   AGING CELL

An integrative study of five biological clocks in somatic and mental health

(2021) Rick Jansen et al.   eLife

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

(2021) Elina Sillanpää et al.   Clinical Epigenetics

The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets

(2021) Adiv A. Johnson et al.   AGEING RESEARCH REVIEWS

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health

(2021) Brian Joyce et al.   CIRCULATION RESEARCH

Epigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV)

(2021) Stephanie Shiau et al.   CLINICAL INFECTIOUS DISEASES

Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes

(2021) Thatchawan Thanasupawat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

(2021) Yuko Sato et al.   NATURE

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

(2021) Chengran Yang et al.   NATURE NEUROSCIENCE

Effect of TNFα stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia

(2021) Zaipul I. Md Dom et al.   Scientific Reports

Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

(2021) Chris P. Verschoor et al.   Clinical Epigenetics

Exercise plasma boosts memory and dampens brain inflammation via clusterin

(2021) Zurine De Miguel et al.   NATURE

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

(2021) Pei-Lun Kuo et al.   Frontiers in Aging Neuroscience

Misexpression of genes lacking CpG islands drives degenerative changes during aging

(2021) Jun-Yeong Lee et al.   Science Advances

DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921

(2020) Ruth A. Sibbett et al.   BMC Psychiatry

Personal aging markers and ageotypes revealed by deep longitudinal profiling

(2020) Sara Ahadi et al.   NATURE MEDICINE

Sexual-dimorphism in human immune system aging

(2020) Eladio J. Márquez et al.   Nature Communications

Temporal changes in the gene expression heterogeneity during brain development and aging

(2020) Ulaş Işıldak et al.   Scientific Reports

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

(2020) Xia Li et al.   eLife

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort

(2020) Oliver Robinson et al.   AGING CELL

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

(2020) Mohamed-Amin Choukrallah et al.   BMC GENOMICS

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

(2020) Daniel W Belsky et al.   eLife

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

(2020) Adiv A. Johnson et al.   AGEING RESEARCH REVIEWS

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

(2020) Fedor Galkin et al.   AGEING RESEARCH REVIEWS

Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue

(2020) Nicholas Holzscheck et al.   Aging-US

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

(2020) Fedor Galkin et al.   iScience

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

(2020) Benoit Lehallier et al.   AGING CELL

Genetics meets proteomics: perspectives for large population-based studies

(2020) Karsten Suhre et al.   NATURE REVIEWS GENETICS

A site-specific map of the human plasma glycome and its age and gender-associated alterations

(2020) Alexander A. Merleev et al.   Scientific Reports

Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease

(2020) Erik B. van den Akker et al.   Circulation-Genomic and Precision Medicine

GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

(2020) Cathal McCrory et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

The Gut Microbiome, Aging, and Longevity: A Systematic Review

(2020) Varsha D. Badal et al.   Nutrients

Plasma proteomic biomarker signature of age predicts health and life span

(2020) Toshiko Tanaka et al.   eLife

DNA methylation GrimAge strongly predicts lifespan and healthspan

(2019) Ake T. Lu et al.   Aging-US

A Review on Quantitative Multiplexed Proteomics

(2019) Nishant Pappireddi et al.   CHEMBIOCHEM

Chromatin accessibility and the regulatory epigenome

(2019) Sandy L. Klemm et al.   NATURE REVIEWS GENETICS

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

The Genetics of Aging: A Vertebrate Perspective

(2019) Param Priya Singh et al.   CELL

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

(2019) Peter D. Fransquet et al.   Clinical Epigenetics

Age Mosaicism across Multiple Scales in Adult Tissues

(2019) Rafael Arrojo e Drigo et al.   Cell Metabolism

Biomarkers for aging identified in cross-sectional studies tend to be non-causative

(2019) Paul G Nelson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

DNA methylation-based estimator of telomere length

(2019) Ake T. Lu et al.   Aging-US

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

(2019) Qian Zhang et al.   Genome Medicine

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

(2019) Joris Deelen et al.   Nature Communications

A meta-analysis of genome-wide association studies identifies multiple longevity genes

(2019) Joris Deelen et al.   Nature Communications

Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

(2019) Camilla S. L. Tuttle et al.   AGING CELL

An epigenetic predictor of death captures multi-modal measures of brain health

(2019) Robert F. Hillary et al.   MOLECULAR PSYCHIATRY

Plasma protein patterns as comprehensive indicators of health

(2019) Stephen A. Williams et al.   NATURE MEDICINE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

An epigenetic biomarker of aging for lifespan and healthspan

(2018) Morgan E. Levine et al.   Aging-US

Advanced age results in a diminished endothelial glycocalyx

(2018) Daniel R. Machin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Promises and pitfalls of untargeted metabolomics

(2018) Ilya Gertsman et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Epigenetics of T cell aging

(2018) Jörg J. Goronzy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Confucian Values as a Buffer Against Age-Based Stereotype Threat for Chinese Older Adults

(2018) Shyuan Ching Tan et al.   JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES

DNA methylation loss in late-replicating domains is linked to mitotic cell division

(2018) Wanding Zhou et al.   NATURE GENETICS

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Using deep learning to model the hierarchical structure and function of a cell

(2018) Jianzhu Ma et al.   NATURE METHODS

Quantitative analysis of population-scale family trees with millions of relatives

(2018) Joanna Kaplanis et al.   SCIENCE

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

(2018) Ake T. Lu et al.   Nature Communications

Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification

(2018) Polina Mamoshina et al.   Frontiers in Genetics

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Extracting biological age from biomedical data via deep learning: too much of a good thing?

(2018) Timothy V. Pyrkov et al.   Scientific Reports

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

A multi-tissue full lifespan epigenetic clock for mice

(2018) Michael J. Thompson et al.   Aging-US

Quantitative characterization of biological age and frailty based on locomotor activity records

(2018) Timothy V. Pyrkov et al.   Aging-US

PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging

(2018) Eugene Bobrov et al.   Aging-US

Mendelian Randomization

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The correlation of methylation levels measured using Illumina 450K and EPIC BeadChips in blood samples

(2017) Mark W Logue et al.   Epigenomics

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

(2017) Yan Zhang et al.   Nature Communications

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

(2017) Patrice D. Cani et al.   Frontiers in Microbiology

A null mutation in SERPINE1 protects against biological aging in humans

(2017) Sadiya S. Khan et al.   Science Advances

Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study

(2017) Manuela J. Rist et al.   PLoS One

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

(2016) Qiong Lin et al.   Aging-US

DNA methylation-based measures of biological age: meta-analysis predicting time to death

(2016) Brian H. Chen et al.   Aging-US

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease

(2016) Peter Ganz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The World report on ageing and health: a policy framework for healthy ageing

(2016) John R Beard et al.   LANCET

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow

(2016) Eva Gorrochategui et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

(2016) Laura Perna et al.   Clinical Epigenetics

Simplified Assay for Epigenetic Age Estimation in Whole Blood of Adults

(2016) Laura Vidal-Bralo et al.   Frontiers in Genetics

Functional metagenomic profiling of intestinal microbiome in extreme ageing

(2016) Simone Rampelli et al.   Aging-US

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

(2015) Morgan E Levine et al.   Aging-US

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

(2015) Steve Horvath et al.   Aging-US

Three-dimensional human facial morphologies as robust aging markers

(2015) Weiyang Chen et al.   CELL RESEARCH

Measuring Biological Age via Metabonomics: The Metabolic Age Score

(2015) Johannes Hertel et al.   JOURNAL OF PROTEOME RESEARCH

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing–activated transfer of a mobile genetic element

(2015) Joshua P. Ramsay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

(2015) Wenqian Zhang et al.   GENOME BIOLOGY

Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study

(2014) Maitreyee Bose et al.   BMC BIOINFORMATICS

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Circulating Proteomic Signatures of Chronological Age

(2014) Cristina Menni et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

A revival of parabiosis in biomedical research

(2014) A Eggel et al.   SWISS MEDICAL WEEKLY

Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

(2014) Krista Fischer et al.   PLOS MEDICINE

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Metformin: Do we finally have an anti-aging drug?

(2013) Vladimir N. Anisimov   CELL CYCLE

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?

(2013) J. L. Sanders et al.   EPIDEMIOLOGIC REVIEWS

Metabolomic markers reveal novel pathways of ageing and early development in human populations

(2013) Cristina Menni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Glycans Are a Novel Biomarker of Chronological and Biological Ages

(2013) Jasminka Krištić et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

(2013) Sebastiano Collino et al.   PLoS One

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Human serum metabolic profiles are age dependent

(2012) Zhonghao Yu et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

(2012) M. E. Levine   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

(2012) Jiapeng Lu et al.   PLoS One

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information

(2012) Jan Krumsiek et al.   PLoS Genetics

Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array

(2011) Geoffrey S. Baird et al.   AMERICAN JOURNAL OF PATHOLOGY

High density DNA methylation array with single CpG site resolution

(2011) Marina Bibikova et al.   GENOMICS

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

(2011) Martin Lundberg et al.   NUCLEIC ACIDS RESEARCH

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Age-Related Differences in Plasma Proteins: How Plasma Proteins Change from Neonates to Adults

(2011) Vera Ignjatovic et al.   PLoS One

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism

(2009) Pasi Soininen et al.   ANALYST

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Genome-wide DNA methylation profiling using Infinium®assay

(2009) Marina Bibikova et al.   Epigenomics

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Analysis of the adult human plasma metabolome

(2008) Kay A Lawton et al.   PHARMACOGENOMICS

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY