Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Ryeo-Eun Go, Sung-Moo Lee, Young-Jun Shin, Min-Seok Kim, Chul-Min Park, Eul-Bee Ko, Soochong Kim, Kyung-Chul Choi
Summary: Cigarette smoke substances can cause various diseases, but evaluating their toxicity is challenging. This study compared the sensitivity of two animal models to cigarette smoke and identified the optimal exposure time in the lung injury rat model.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Sascha Jung, Javier Arcos Hodar, Antonio del Sol
Summary: In this study, MultiTIMER, the first multi-tissue aging clock, is presented. It can measure the biological age of cells from their transcriptional profiles by evaluating key cellular processes, instead of the chronological age. The authors applied MultiTIMER to a large number of transcriptional profiles and demonstrated its accuracy in responding to cellular stressors, known interventions, and dysregulated cellular functions.
Article
Pharmacology & Pharmacy
Sung-Moo Lee, Young-Jun Shin, Ryeo-Eun Go, Seon-Hee Bae, Cho-Won Kim, Soochong Kim, Min-Seok Kim, Kyung-Chul Choi
Summary: Exposure to cigarette smoke can exacerbate lung injury induced by bleomycin and lipopolysaccharide in rats, leading to inflammatory cell recruitment and increased expression of cytokines in the lung tissues. This study demonstrates that repeated exposure to cigarette smoke may worsen the progression of lung disease.
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Cell Biology
Beatriz Mangueira Saraiva-Romanholo, Isabella Santos de Genaro, Francine Maria de Almeida, Soraia Nogueira Felix, Marina Ribeiro Cottes Lopes, Thais Santos Amorim, Rodolfo Paula Vieira, Fernanda Magalhaes Arantes-Costa, Milton Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio, Carla Maximo Prado
Summary: Cigarette smoke and sodium hypochlorite have an impact on lung mechanics and inflammation. Exposure to these irritants alone induces changes in the lungs. Co-exposure to both irritants reduces lung inflammation, but increases the acidity of mucus.
Article
Biochemistry & Molecular Biology
Maria Vittoria Cavicchioli, Mariangela Santorsola, Nicola Balboni, Daniele Mercatelli, Federico Manuel Giorgi
Summary: The correlation between the metabolome and transcriptome can provide insights into cancer, biomarker discovery, and prediction of metabolite quantities based on transcriptomics data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Talal Ahmed, Mark A. Carty, Stephane Wenric, Jonathan R. Dry, Ameen A. Salahudeen, Aly A. Khan, Eric Lefkofsky, Martin C. Stumpe, Raphael Pelossof
Summary: Reproducibility of results obtained using RNA data in cancer research remains challenging. Current RNA correction algorithms require access to patient-level data, but SpinAdapt computes corrections using aggregate statistics, preserving patient data privacy. SpinAdapt outperforms other methods on publicly available cancer studies and can correct new samples for unbiased evaluation.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Medicine, Research & Experimental
Camila Liyoko Suehiro, Natalia Tiemi Simokomaki Souza, Emerson Batista da Silva, Maysa Mariana Cruz, Roseane Martins Laia, Stheffany de Oliveira Santos, Fernanda Paula Roncon Santana-Novelli, Thamyres Barros Pereira de Castro, Fernanda D. T. Q. S. Lopes, Nathalia Montouro Pinheiro, Iolanda de Fatima Lopes Calvo Tiberio, Clarice Rosa Olivo, Maria Isabel Alonso-Vale, Marco Antonio Maximo Prado, Vania Ferreira Prado, Alessandra Choqueta de Toledo-Arruda, Carla Maximo Prado
Summary: The effects of aerobic exercise training on pulmonary emphysema in mice are dependent on the integrity of the lung cholinergic signaling.
Article
Pharmacology & Pharmacy
Jean-Baptiste Woillard, Marc Labriffe, Jean Debord, Pierre Marquet
Summary: This study aimed to estimate the AUC of tacrolimus in organ transplant patients using Xgboost ML models, comparing b.i.d. and q.d. dosing regimens. The ML models showed excellent AUC estimation performance in test datasets and outperformed Bayesian estimation in six independent full-PK datasets, demonstrating their utility for routine TAC exposure estimation and dose adjustment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Respiratory System
Nok Him Fung, Hao Wang, Ross Vlahos, Nick Wilson, Angel F. Lopez, Catherine M. Owczarek, Steven Bozinovski
Summary: This study identifies CSL311 as a therapeutic antibody that significantly inhibits immunopathology and lung injury caused by acute CS exposure.
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)