Undulating changes in human plasma proteome profiles across the lifespan

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

(2018) Peer Aramillo Irizar et al.   Nature Communications

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study

(2018) Sharon J. Sha et al.   JAMA Neurology

Transcriptional Signatures of Aging

(2017) R. Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

A Young Blood Environment Decreases Aging of Senile Mice Kidneys

(2017) Qi Huang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

(2017) Emanuele Di Angelantonio et al.   LANCET

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Aptamers as targeted therapeutics: current potential and challenges

(2017) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

(2017) Jérôme Carayol et al.   Nature Communications

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

(2017) Kelly D. Sullivan et al.   Scientific Reports

Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging

(2017) Alan A. Cohen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of serum protein biomarkers for utrophin based DMD therapy

(2017) Simon Guiraud et al.   Scientific Reports

Sex Differences in Lifespan

(2016) Steven N. Austad et al.   Cell Metabolism

Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

(2016) R. Ostan et al.   CLINICAL SCIENCE

Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease

(2016) Peter Ganz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model

(2016) Joseph M. Castellano et al.   Scientific Reports

Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease

(2016) Benoit Lehallier et al.   JAMA Neurology

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Efficient Test and Visualization of Multi-Set Intersections

(2015) Minghui Wang et al.   Scientific Reports

Blood-Borne Revitalization of the Aged Brain

(2015) Joseph M. Castellano et al.   JAMA Neurology

Regularization Paths for Generalized Linear Models via Coordinate Descent

(2015) Jerome Friedman et al.   Journal of Statistical Software

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

(2014) Martina Sattlecker et al.   Alzheimers & Dementia

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

Omics technologies and the study of human ageing

(2013) Ana M. Valdes et al.   NATURE REVIEWS GENETICS

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Protein Signature of Lung Cancer Tissues

(2012) Michael R. Mehan et al.   PLoS One

Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome

(2011) Markus Britschgi et al.   MOLECULAR & CELLULAR PROTEOMICS

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE