A null mutation in SERPINE1 protects against biological aging in humans

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

(2017) Ci Song et al.   Journal of the American Heart Association

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

Whole-Genome Sequencing of a Healthy Aging Cohort

(2016) Galina A. Erikson et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease

(2016) P. Factor-Litvak et al.   PEDIATRICS

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes

(2015) Steven C. Hunt et al.   Circulation-Cardiovascular Genetics

Quantification of biological aging in young adults

(2015) Daniel W. Belsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes

(2015) Steven C. Hunt et al.   Circulation-Cardiovascular Genetics

Association Between Shortened Leukocyte Telomere Length and Cardiometabolic OutcomesCLINICAL PERSPECTIVE

(2014) Matthew J.J. D’Mello et al.   Circulation-Cardiovascular Genetics

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

(2014) M. Eren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

(2014) P. C. Haycock et al.   BMJ-British Medical Journal

Tracking and fixed ranking of leukocyte telomere length across the adult life course

(2013) Athanase Benetos et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N ω -Nitro- l -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence

(2013) Amanda E. Boe et al.   CIRCULATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of seven loci affecting mean telomere length and their association with disease

(2013) Veryan Codd et al.   NATURE GENETICS

Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis

(2013) Jinzhao Zhao et al.   PLoS One

Telomeres shorten at equivalent rates in somatic tissues of adults

(2013) Lily Daniali et al.   Nature Communications

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

(2012) J. Huang et al.   BLOOD

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

(2012) M. E. Levine   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Plasminogen activator inhibitor 1 - insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence

(2012) David J. Elzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

(2011) Joris Deelen et al.   AGE

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

(2011) Joris Deelen et al.   AGING CELL

Telomere Length in Prospective and Retrospective Cancer Case-Control Studies

(2010) K. A. Pooley et al.   CANCER RESEARCH

REVIEW: Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions

(2010) Matteo Cesari et al.   Cardiovascular Therapeutics

Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants

(2010) J Ølholm et al.   INTERNATIONAL JOURNAL OF OBESITY

A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates

(2010) Yuko Izuhara et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

(2010) Masayuki Kimura et al.   Nature Protocols

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Multimarker Approach to Evaluate Correlates of Vascular Stiffness

(2008) Wolfgang Lieb et al.   CIRCULATION

Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine

(2008) James H. Stein et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY